Manoron
Manoron Uses, Dosage, Side Effects, Food Interaction and all others data.
Manoron provides quick relief of various symptoms of cerebral and peripheral circulation disorders. Manoron protects attacks of vascular headache such as migraine. Manoron normalizes cerebral circulation time and improves cerebral irrigation in patients suffering from the disorders of cerebral circulation. Manoron normalizes arterial pulsations in patients suffering from vasospastic disorders. Manoron significantly increases the rate of inflow or pulsation and the blood flow in the most affected limb as well as the walking distance of patients suffering from intermittent claudication.
Manoron acts as an antihistamine, labyrinthine sedative and a peripheral antivasoconstrictor. Inarzin is a selective calcium antagonist, inhibiting the influx of Ca2+ intracellularly. It prevents the Ca2+ dependent contraction of arterial smooth muscle by inhibiting Ca2+ influx through smooth muscle calcium channels and thereby, improves vestibular symptoms and prevents peripheral arterial disease.
Manoron is an antihistamine and a calcium channel blocker. Histamines mediate a number of activities such as contraction of smooth muscle of the airways and gastrointestinal tract, vasodilatation, cardiac stimulation, secretion of gastric acid, promotion of interleukin release and chemotaxis of eosinophils and mast cells. Competitive antagonists at histamine H1 receptors may be divided into first (sedating) and second (non-sedating) generation agents. Some, such as Manoron also block muscarinic acetylcholine receptors and are used as anti-emetic agents. Manoron through its calcium channel blocking ability also inhibits stimulation of the vestibular system.
| Trade Name | Manoron |
| Generic | Cinnarizine |
| Cinnarizine Other Names | Cinarizina, Cinnarizine, Cinnarizinum |
| Type | |
| Formula | C26H28N2 |
| Weight | Average: 368.524 Monoisotopic: 368.22524891 |
| Groups | Approved, Investigational |
| Therapeutic Class | Anti vertigo drugs |
| Manufacturer | |
| Available Country | Thailand |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
It is mainly used for the symptomatic treatment of nausea and vertigo due to Meniere's disease and other labyrinthine disturbances and for the prevention and treatment of motion sickness. It is also used in the management of various vascular disorders.
Cerebral circulatory disorders:
- Prophylaxis and maintenance therapy for symptoms of cerebral vascular spasms and arteriosclerosis such as dizziness, ear buzzing (tinnitus), vascular headache, unsociability and irritability, fatigue, sleep rhythm disorders such as premature awakening, involutional depressions, loss of memory and lack of concentration, incontinence and other disorders due to aging.
- Sequel of cerebral and cranial trauma.
- Post-apoplectic disorders.
- Migraine.
Peripheral circulatory disorders: Prophylaxis and maintenance therapy for symptoms of vascular spasms and arteriosclerosis (obliterating arteritis, thromboangitis obliterans, Raynaud's disease, diabetes, acrocyanosis, perrio, etc.) such as: intermittent claudication, trophic disturbances, pregangrene, trophic and varicose ulcers, paraesthesia, nocturnal cramps, cold extremities.
Disorders of balance:
- Prophylaxis and maintenance therapy for symptoms of labyrinthine arteriosclerosis, vestibular irritability, Meniere's syndrome, such as vertigo, dizziness, giddiness, syncopal attacks, tinnitus, nystagmus, nausea and vomiting.
- Prophylaxis of motion sickness.
Manoron is also used to associated treatment for these conditions: Balance Disorders, Dizziness, Motion Sickness, Nausea, Peripheral Artery Disease (PAD), Raynaud's Phenomenon, Inadequate cerebral circulation, Peripheral vasculopathy
How Manoron works
Manoron inhibits contractions of vascular smooth muscle cells by blocking L-type and T-type voltage gated calcium channels. Manoron has also been implicated in binding to dopamine D2 receptors, histamine H1 receptors, and muscarinic acetylcholine receptors.
Dosage
Manoron dosage
Peripheral vascular disease:
- Adult: 75 mg bid or tid.
Cerebrovascular disorders:
- Adult: 75 mg once daily.
Motion sickness:
- Adult: 30 mg 2 hr before travel then 15 mg 8 hrly during the journey if necessary.
- Child: 5-12 yr 15 mg 2 hr before travel then 7.5 mg 8 hrly during the journey as necessary.
Vertigo and vestibular disorders:
- Adult: 30 mg tid or 75 mg 1-2 times daily.
- Child: 5-12 yr 15 mg tid.
Side Effects
Side effects such as somnolence and gastrointestinal disturbances are extremely rare. They are transient and may be readily prevented by achieving the optimal dosage gradually. Combination therapy with other drugs is possible. Whenever indicated, caution should be taken in hypotension (high doses). Rarely, extrapyramidal symptoms in elderly on prolonged therapy.
Precaution
Patient with hypotension (high dose), Parkinson's disease, porphyria. Renal and hepatic impairment. Childn. Pregnancy and lactation.
Interaction
Concurrent use of alcohol, CNS depressants or tricyclic antidepressants may potentiate the sedative effects of either these drugs or of Manoron. Therefore, it is advisable to avoid these drugs while taking Manoron.
Pregnancy & Breastfeeding use
Pregnancy Category C. The safety of Manoron in human pregnancy has not been established. Therefore, it is not advisable to administer Manoron in pregnancy.
Lactation: It is not known if Manoron is excreted in human breast milk. Use of Manoron during breast feeding is not advised.
Contraindication
Contraindicated in Known hypersensitivity to Manoron, Parkinson’s disease, Hypotension
Special Warning
Neonates: Manoron is not indicated in neonates.
Acute Overdose
Symptoms: Consciousness alterations ranging from somnolence to stupor and coma, vomiting, extrapyramidal symptoms, hypotonia; seizures may occur in young children.
Management: Symptomatic and supportive treatment. May consider admin of activated charcoal within 1 hr of ingestion.
Innovators Monograph
You find simplified version here Manoron
Manoron contains Cinnarizine see full prescribing information from innovator Manoron Monograph, Manoron MSDS, Manoron FDA label
FAQ
What is Manoron used for?
It's used for travel sickness (also called motion sickness) dizziness and sickness caused by inner ear problems (such as vertigo, tinnitus and Ménière's disease).
How safe is Manoron?
Manoron can safe to be taken by most adults and children aged 5 years and above. Manoron is not suitable for some people. Tell your doctor or pharmacist if you have: had an allergic reaction to Manoron or any other medicines in the past.
How does Manoron work?
Manoron blocks the receptors in the vomiting centre, preventing it from receiving nerve messages from the vestibular apparatus. This helps to reduce symptoms such as nausea, vomiting dizziness and vertigo.
What are the common side effects of Manoron?
Common side effects of include are drowsiness, sweating, dry mouth, headache, skin problems, lethargy, gastrointestinal irritation, hypersensitivity reactions, as well as movement problems/muscle rigidity, and tremor.
Is Manoron safe during pregnancy?
Manoron is not usually recommended during pregnancy.
Is Manoron safe during breastfeeding?
Manoron is not usually recommended during pregnancy or while breastfeeding.
Can I drink alcohol with Manoron?
Avoid drinking alcohol while taking Manoron. Alcohol increases the chance of side effects. To prevent travel sickness, take Manoron 2 hours before your journey. You can take another dose 8 hours later if you need to.
Can I drive after taking Manoron?
Manoron can cause drowsiness. If this happens, do not drive and do not use tools or machines.
When should be taken of Manoron?
To prevent travel sickness, take Manoron 2 hours before your journey. You can take another dose 8 hours later if you need to.
Can Manoron be taken without food?
Manoron should preferably be taken after meals. The tablets may be sucked, chewed or swallowed whole with water.
How long does Manoron take to work?
Manoron can take up to 4 hours for the medicine to reach its full effect.
What is the half-life of Manoron?
The reported elimination half-life for Manoron ranges from 4 to 24 hours.
Who should not take Manoron?
Contraindicated in patients with Parkinson's disease, newborns, and hypersensitivity.
What happen If I stop taking Manoron?
If you've been prescribed Manoron to help with inner ear problems, your symptoms may return if you stop taking it.
What happens if I miss a dose?
If you forget to take a dose of Manoron, take it as soon as you remember. Unless it's nearly time for your next dose. In which case, skip the missed dose and take your next dose at the usual time. It's important to leave at least 8 hours between doses. Do not take 2 doses at the same time. Never take an extra dose to make up for a forgotten one.
What happen if I overdose on Manoron?
Taking too much Manoron can make you very sleepy or confused, feel sick or be sick, feel weak or shaky, or give you a very fast, uneven or pounding heartbeat (palpitations). Too much Manoron can give a child a fit or seizure.
Can Manoron causes my weight gain?
Manoron may cause weight gain.
Can Manoron cause heart palpitations?
Taking too much Manoron can make you very sleepy or confused, feel sick or be sick, feel weak or shaky, or give you a very fast, uneven or pounding heartbeat .
Can Manoron be taken long term?
Manoron should not be taken long term due to its potential side effects. Limiting pack size may reduce the likelihood of long term use.
Can I take Manoron every day?
Adults and children aged 12 years or older – the usual dose is 2 tablets, taken 3 times a day. Children aged 5 to 11 years – the usual dose is 1 tablet, taken 3 times a day.
