Mantadil
Mantadil Uses, Dosage, Side Effects, Food Interaction and all others data.
Mantadil is a first generation phenylpiperazine class antihistamine used to treat urticaria, rhinitis, pruritus, and other allergy symptoms. Mantadil also has some local anesthetic, anticholinergic, and antiserotonergic properties, and can be used as an antiemetic.
| Trade Name | Mantadil |
| Availability | Over the counter |
| Generic | Chlorcyclizine |
| Chlorcyclizine Other Names | Chlorcyclizin, Chlorcyclizine, Chlorcyclizinum, Clorciclicina, Clorciclizina, Clorciclizinio |
| Related Drugs | prednisone, cetirizine, loratadine, fluticasone nasal, promethazine, Zyrtec |
| Type | |
| Formula | C18H21ClN2 |
| Weight | Average: 300.826 Monoisotopic: 300.139326389 |
| Protein binding | about 85 to 90%. |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Food Interaction
- Avoid excessive or chronic alcohol consumption. Alcohol may increase the drowsiness caused by chlorcyclizine.
[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.
Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.
Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
Mantadil Drug Interaction
Moderate: contained in alcoholic beverages , quetiapine, quetiapineUnknown: aspirin, fexofenadine, hydrocortisone topical, multivitamin, aluminum hydroxide / magnesium carbonate, levonorgestrel, omega-3 polyunsaturated fatty acids, acetaminophen, acetaminophen, acetaminophen / pseudoephedrine, emtricitabine / tenofovir, eflornithine topical, ascorbic acid, cholecalciferol, zinc sulfate
Mantadil Disease Interaction
Moderate: anticholinergic effects, asthma/COPD, cardiovascular, renal/liver disease
Volume of Distribution
After a single oral dose of 2 mg/kg to 4 subjects, average peak plasma concentrations of about 0.05 mg/L and 0.03 mg/L were attained in 5 h for unchanged drug and norchlorcyclizine, respectively. After oral administration of 50 mg 3 times a day for 6 days, plasma concentrations of norchlorcyclizine of 0.05 to 0.11 mg/L were reported on the first day after the cessation of treatment and plasma concentrations of 0.02 to 0.04 mg/L were found on the 10th day after cessation of treatment [Kuntzman et al. 1973].
Elimination Route
Readily absorbed after oral administration and widely distributed throughout the body. Metabolised by N-demethylation to form norchlorcyclizine and by N-oxidation.
Half Life
about 12 h.
Elimination Route
Slowly excreted in the urine; measurable amounts of norchlorcyclizine have been detected in the urine for up to 3 weeks after the cessation of chronic oral administration. About 0.5% of a single dose is excreted in the urine as the N-oxide.
Innovators Monograph
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