Mapradrox Dry

Mapradrox Dry Uses, Dosage, Side Effects, Food Interaction and all others data.

Mapradrox Dry Monohydrate (Mapradrox Dry Monohydrate) is an acid-stable semi-synthetic oral antibiotic in the cephalosporin family of drugs. Mapradrox Dry acts by preventing bacteria from forming protective cell wall necessary for survival. It has superior pharmacokinetic profile over all first generation cephalosporins.

Mapradrox Dry, a first-generation cephalosporin antibiotic, is used to treat urinary tract infections, skin and skin structure infections, pharyngitis, and tonsillitis.

Trade Name Mapradrox Dry
Availability Prescription only
Generic Cefadroxil
Cefadroxil Other Names Cefadroxil, Cefadroxilo, Cefadroxilum, Cephadroxil, D-Cefadroxil
Related Drugs amoxicillin, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, ceftriaxone, levofloxacin, Augmentin
Type Syrup
Formula C16H17N3O5S
Weight Average: 363.388
Monoisotopic: 363.088891359
Protein binding

Binding rates of cefadroxil were 28.1% by U.F. method

Groups Approved, Vet approved, Withdrawn
Therapeutic Class First generation Cephalosporins
Manufacturer Mapra Laboratories Pvt Ltd
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Mapradrox Dry
Mapradrox Dry

Uses

Mapradrox Dry Monohydrate (Mapradrox Dry Monohydrate) is used for the treatment of patients with infection caused by susceptible strains of the designated organisms in the following diseases:

*Upper respiratory tract infections caused by Streptococcus pyogenes (Group A beta-hemolytic Streptococci) and Streptococcus pneumoniae.

* Urinary tract infections caused by E. coli, Proteus mirabilis, and Klebsiella species.

* Skin and soft tissue infections caused by Staphylococci (including penicillinase producing strains) and Streptococci.

Mapradrox Dry is also used to associated treatment for these conditions: Bacterial Infections, Infection and inflammatory reaction due to internal prosthetic device, implant, and graft, Skin and Subcutaneous Tissue Bacterial Infections, Streptococcal Pharyngitis, Streptococcal tonsillitis, Urinary Tract Infection

How Mapradrox Dry works

Like all beta-lactam antibiotics, cefadroxil binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefadroxil interferes with an autolysin inhibitor.

Dosage

Mapradrox Dry dosage

The bioavailability and consequent chemotherapeutic effects of Mapradrox Dry are unaffected by foods. It may, therefore, be taken with meals or on an empty stomach. Administration with food may be helpful in diminishing potential gastrointestinal complaints occasionally associated with oral cephalosporin therapy.IndicationAdult (dose)Children (Dose)

Upper respiratory tract Infections

1 gm per day in single (q.d.) or divided doses (b.i.d.) for 10 days 12 hourly

30 mg/kg/day in a single or in equally divided doses every 12 hours

Urinary Tract Infections

1 or 2 gm per day in single (q.d.) or divided doses (b.i.d.)

30 mg/kg/day in equally divided doses every 12 hours

For all other UTIs

2 gm per day in divided doses (b.i.d)

30 mg/kg/day in equally divided doses every 12 hours

Skin & soft tissue Infections

1 gm per day in single (q.d.) or divided doses (b.i.d.)

30 mg/kg/day in equally divided doses every 12 hours

Prophylaxis against bacterial endocarditis

2 gm 1 hour prior to the procedure

50 mg/kg 1 hour prior to the procedure

Direction for Reconstitution of suspension

For 100 ml suspension and 100 ml DS suspension: Add 65 ml (13 measuring spoonful) of boiled and cooled water to the dry mixture in the bottle. For ease of preparation add water to the bottle in two portions. Shake well after each addition until all the powder is in suspension.

For 60 ml suspension: Add 40 ml (8 measuring spoonful) of boiled and cooled water to the dry mixture in the bottle. For ease of preparation add water to the bottle in two portions. Shake well after each addition until all the powder is in suspension.

Paediatric Drops: Add 10 ml (2 measuring spoonful) to the bottle and shake vigorously.

Note: Shake both oral suspension and paediatric drops well before each use. Keep the bottle tightly closed. The reconstituted suspension should be stored in a cool and dry place, preferably in refrigerator and unused portion should be discarded after 14 days.

Side Effects

Generally cefadroxil is well tolerated. However, the most commonly reported side effects are gastrointestinal disturbances and hypersensitivity phenomena. Side effects including nausea, vomiting, diarrhoea, dyspepsia, abdominal discomfort, fever, dizziness, headache, arthralgia may also occur.

Toxicity

Nausea, vomiting, diarrhoea, allergic rashes may occur

Precaution

History of hypersensitivity to penicillins or any other β-lactam drugs. History of GI disease (particularly colitis), severe allergies or asthma. Renal impairment. Pregnancy and lactation.

Interaction

There is no known clinically important drug interactions with Mapradrox Dry.

Food Interaction

  • Take with or without food. Administration with food may be helpful in diminishing potential gastrointestinal complaints occasionally associated with oral cephalosporin therapy.

Elimination Route

Mapradrox Dry is well absorbed on oral administration; food does not interfere with its absorption.

Half Life

1.5 hours

Elimination Route

Over 90% of the drug is excreted unchanged in the urine within 24 hours. Mapradrox Dry was detected in the placenta and breast milk.

Pregnancy & Breastfeeding use

Mapradrox Dry (Mapradrox Dry Monohydrate) is widely used as a first-line oral antibiotic for the treatment of uncomplicated urinary tract infections in pregnant women.

Contraindication

Mapradrox Dry is contraindicated in patients with a history of hypersensitivity to any of the ingredients.

Acute Overdose

If amounts >250 mg/kg is ingested, gastric lavage or simulation of vomiting is appropriate.

Storage Condition

Store between 20-25°C. Reconstituted powder for suspension: Store between 2-8°C.

Innovators Monograph

You find simplified version here Mapradrox Dry

Mapradrox Dry contains Cefadroxil see full prescribing information from innovator Mapradrox Dry Monograph, Mapradrox Dry MSDS, Mapradrox Dry FDA label

FAQ

What is Mapradrox Dry used for?

Mapradrox Dry is used to treat certain infections caused by bacteria such as infections of the skin, throat, tonsils, and urinary tract. Mapradrox Dry is used to treat bacterial infections in many different parts of the body. Mapradrox Dry is a broad-spectrum antibiotic of the cephalosporin type, effective in Gram-positive and Gram-negative bacterial infections.

How safe is Mapradrox Dry?

Mapradrox Dry may rarely cause a severe intestinal condition due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped.

How does Mapradrox Dry work?

Mapradrox Dry works by killing bacteria.

What are the common side effects of Mapradrox Dry?

Common side effects of Mapradrox Dry are include:

  • indigestion.
  • nausea.
  • vomiting.
  • diarrhea.
  • intense abdominal pain.

Is Mapradrox Dry safe during pregnancy ?

Animal reproductive studies have not indicated a risk of impaired fertility or harm to the fetus. There are no adequate, controlled studies during human pregnancy.

Is Mapradrox Dry safe during breastfeeding?

Mapradrox Dry is acceptable in nursing mothers.

Can I drink alcohol with Mapradrox Dry?

Avoid alcohol while you take Mapradrox Dry may be a good idea. Alcohol may decrease your body's ability to fight your UTI. It's important to talk to your doctor, who knows your medical history.

Can I take Mapradrox Dry on an empty stomach?

You may take Mapradrox Dry with or without food. Take with food if Mapradrox Dry upsets your stomach.

When should be taken of Mapradrox Dry?

Mapradrox Dry is usually taken with or without food every 12 or 24 hours . Take Mapradrox Dry at around the same times every day.

How long does Mapradrox Dry take to work?

Peak concentrations of Mapradrox Dry are reached one hour after dosing; however, it may take up to 48 hours before infection-related symptoms start to abate.

What is the half life of Mapradrox Dry ?

Mapradrox Dry is eliminated far more slowly than comparable oral cephalosporins so that intervals between doses can be prolonged to 12-24 hours. Roughly 90% of the substance is eliminated in unchanged form through the kidneys within 24 hours.

How long should I take Mapradrox Dry?

For throat and tonsil infections, take Mapradrox Dry for a total of 10 days. If you have a urinary tract or skin infection, your provider will determine the right amount of time for you to take this antibiotic.

Who should not take Mapradrox Dry?

You should not take Mapradrox Dry if you are allergic to Mapradrox Dry or other cephalosporin antibiotic. Tell your doctor if you have ever had an allergy to any drug (especially penicillin); intestinal problems, such as colitis.

Can Mapradrox Dry cause anxiety?

Mapradrox Dry can causes anxiety also with other common side effects.

Does Mapradrox Dry cause hair loss?

Mapradrox Dry and Erythromycin are known to cause hair loss.

What happens if I miss a dose of Mapradrox Dry?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What should I avoid while taking Mapradrox Dry?

Mapradrox Dry can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

What happen If I just stop taking Mapradrox Dry?

If you stop taking Mapradrox Dry too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

What happens if I overdose?

Seek emergency medical attention.

Can Mapradrox Dry affects my liver?

Mapradrox Dry may cause a life-threatening side effect, such as pancytopenia and acute liver injury.

*** Taking medicines without doctor's advice can cause long-term problems.
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