Marcoumar

Marcoumar Uses, Dosage, Side Effects, Food Interaction and all others data.

Coumarin derivative that acts as a long-acting oral anticoagulant.

Marcoumar, a coumarin anticoagulant, thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver. Anticoagulants such as phenprocoumon have no direct effect on an established thrombus, nor do they reverse ischemic tissue damage (damage caused by an inadequate blood supply to an organ or part of the body). However, once a thrombus has occurred, the goal of anticoagulant treatment is to prevent further extension of the formed clot and prevent secondary thromboembolic complications which may result in serious and possibly fatal sequelae.

Trade Name Marcoumar
Generic Phenprocoumon
Phenprocoumon Other Names Fenprocumon, Fenprocumone, Phenprocoumarol, Phenprocoumarole, Phenprocoumon, Phenprocoumone, Phenprocoumonum, Phenprocumone
Type
Formula C18H16O3
Weight Average: 280.3178
Monoisotopic: 280.109944378
Protein binding

99%

Groups Approved, Investigational
Therapeutic Class
Manufacturer Meda, Meda Pharma
Available Country Netherlands, Switzerland,
Last Updated: September 19, 2023 at 7:00 am
Marcoumar
Marcoumar

Uses

Marcoumar is an anticoagulant drug used for the prevention of thrombosis.

Used for the prevention and treatment of thromboembolic disease including venous thrombosis, thromboembolism, and pulmonary embolism as well as for the prevention of ischemic stroke in patients with atrial fibrillation (AF).

Marcoumar is also used to associated treatment for these conditions: Embolism venous, Myocardial Infarction, Thrombotic events

How Marcoumar works

Marcoumar inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins, this limits the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Depression of three of the four vitamin K-dependent coagulation factors (factors II, VII, and X) results in decreased prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots.

Toxicity

50=500 mg/kg. Symptoms of overdose includes suspected or overt abnormal bleeding (e.g., appearance of blood in stools or urine, hematuria, excessive menstrual bleeding, melena, petechiae, excessive bruising or persistent oozing from superficial injuries).

Food Interaction

  • Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.
  • Ensure consistent Vitamin K intake. Changes in vitamin K intake may impact coagulation.
  • Exercise caution with grapefruit products.
  • Exercise caution with St. John's Wort.

Elimination Route

Bioavailability is close to 100%

Half Life

5-6 days

Innovators Monograph

You find simplified version here Marcoumar

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0000261
http://classyfire.wishartlab.com/tax_nodes/C0000145
http://classyfire.wishartlab.com/tax_nodes/C0002908
http://classyfire.wishartlab.com/tax_nodes/C0002907
http://classyfire.wishartlab.com/tax_nodes/C0003410
http://classyfire.wishartlab.com/tax_nodes/C0002811
http://classyfire.wishartlab.com/tax_nodes/C0000481
http://classyfire.wishartlab.com/tax_nodes/C0003889
http://classyfire.wishartlab.com/tax_nodes/C0004144
http://classyfire.wishartlab.com/tax_nodes/C0000050
http://classyfire.wishartlab.com/tax_nodes/C0004140
http://classyfire.wishartlab.com/tax_nodes/C0000323
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:50438
http://www.hmdb.ca/metabolites/HMDB0015081
http://www.genome.jp/dbget-bin/www_bget?drug:D05457
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=54680692
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506423
https://www.chemspider.com/Chemical-Structure.10441592.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=768
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=8150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=50438
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1465
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000771
http://www.pharmgkb.org/drug/PA450921
https://en.wikipedia.org/wiki/Phenprocoumon
*** Taking medicines without doctor's advice can cause long-term problems.
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