Marplan (PSYCHOANALEPTICS)

Marplan (PSYCHOANALEPTICS) Uses, Dosage, Side Effects, Food Interaction and all others data.

Marplan (PSYCHOANALEPTICS) has the formula 1-benzyl-2-(5-methyl-3-isoxazolylcarbonyl)hydrazine-isocarboxazid. It is a monoamine oxidase inhibitor. It is used in the treatment of major depression, dysthymic disorder, atypical disorder, panic disorder and the phobic disorders. It was first introduced by Roche pharmaceuticals, further developed by Validus pharms Inc and first FDA approved as a prescription drug on July 1st, 1959.

In vivo and in vitro studies demonstrated isocarboxazid-driven inhibition of MAO in the brain, heart, and liver. The reduced MAO activity, caused by isocarboxazid, results in an increased concentration of serotonin, epinephrine, norepinephrine, and dopamine in storage sites throughout the central nervous system (CNS) and sympathetic nervous system. The increase of one or more monoamines is the basis for the antidepressant activity of MAO inhibitors like isocarboxazid.

Trade Name Marplan (PSYCHOANALEPTICS)
Availability Prescription only
Generic Isocarboxazid
Isocarboxazid Other Names Isocarboxazid, Isocarboxazida, Isocarboxazide, Isocarboxazidum
Related Drugs Rexulti, sertraline, trazodone, Lexapro, Zoloft, citalopram, Cymbalta
Type
Formula C12H13N3O2
Weight Average: 231.2505
Monoisotopic: 231.100776675
Protein binding

The pharmacokinetic profile of isocarboxazid have not been fully studied but it is suggested that its properties should be fairly similar to the ones of some analogs like phenelzine and tranylcypromine. These drugs present a very high protein binding percentage.

Groups Approved
Therapeutic Class
Manufacturer
Available Country Denmark, USA
Last Updated: September 19, 2023 at 7:00 am
Marplan (PSYCHOANALEPTICS)
Marplan (PSYCHOANALEPTICS)

Uses

Marplan (PSYCHOANALEPTICS) is a monoamine oxidase inhibitor used to treat enduring and debilitating symptoms of depression following inadequate clinical response to other antidepressant drugs.

Marplan (PSYCHOANALEPTICS) is indicated for the treatment of the enduring and debilitating symptoms of depression that have not responded to other antidepressant drugs. Depression is a common but serious mood disorder. The patient will present changes in its feelings, thoughts, and ability to handle everyday activities. For a mood disorder to be considered as depression, the symptoms should be present for at least two weeks.

Marplan (PSYCHOANALEPTICS) is also used to associated treatment for these conditions: Depression

How Marplan (PSYCHOANALEPTICS) works

Marplan (PSYCHOANALEPTICS) works by irreversibly blocking the action of monoamine oxidases (MAO) in the nervous system. MAO subtypes A and B are involved in the metabolism of serotonin and catecholamine neurotransmitters such as epinephrine, norepinephrine, and dopamine. Marplan (PSYCHOANALEPTICS), as a nonselective MAO inhibitor, binds irreversibly to monoamine oxidase-A (MAO-A) and monoamine oxidase-B (MAO-B). Isocarboxacid, like other monoamine oxidase inhibitors, are unique psychopharmacological agents whose clinical effect is related to the direct action of the monoamine oxidases to transform them into reactive metabolites.

Toxicity

Long-term toxicity studies to evaluate the carcinogenic, mutagenic and fertility impairment potential have not been conducted.

Food Interaction

  • Avoid alcohol. The official product labeling suggests avoiding the use of CNS depressants.
  • Avoid tyramine-containing foods and supplements. Foods that contain tyramine include yogurt, aged cheese, ripe bananas, wine, and sourdough bread.
  • Limit caffeine intake.

[Major] CONTRAINDICATED: Foods that contain large amounts of tyramine may precipitate a hypertensive crisis in patients treated with monoamine oxidase inhibitors (MAOIs).

The mechanism is inhibition of MAO-A, the enzyme responsible for metabolizing exogenous amines such as tyramine in the gut and preventing them from being absorbed intact.

Once absorbed, tyramine is metabolized to octopamine, a substance that is believed to displace norepinephrine from storage granules.



GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of MAOIs.

Use in combination may result in additive central nervous system depression and
MANAGEMENT: In general, patients treated with MAOIs or other agents that possess MAOI activity (e.g., furazolidone, linezolid, procarbazine) should avoid consumption of products that contain large amounts of amines and protein foods in which aging or breakdown of protein is used to increase flavor.

These foods include cheese (particularly strong, aged or processed cheeses), sour cream, wine (particularly red wine), champagne, beer, pickled herring, anchovies, caviar, shrimp paste, liver (particularly chicken liver), dry sausage, salamis, figs, raisins, bananas, avocados, chocolate, soy sauce, bean curd, sauerkraut, yogurt, papaya products, meat tenderizers, fava bean pods, protein extracts, yeast extracts, and dietary supplements.

Caffeine may also precipitate hypertensive crisis so its intake should be minimized as well.

At least 14 days should elapse following discontinuation of MAOI therapy before these foods may be consumed.

Specially designed reference materials and dietary consultation are recommended so that an appropriate and safe diet can be planned.

Patients should be advised to promptly seek medical attention if they experience potential signs and symptoms of a hypertensive crisis such as severe headache, visual disturbances, difficulty thinking, stupor or coma, seizures, chest pain, unexplained nausea or vomiting, and stroke-like symptoms.

Patients should also be counseled not to use MAOIs with alcohol, and to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them.

Elimination Route

The pharmacokinetic profile of isocarboxazid have not been fully studied but it is suggested that its properties should be fairly similar to the ones of some analogs like phenelzine and tranylcypromine. These drugs are readily absorbed by the GI tract, present a low bioavailability and reach peak concentrations in 1-2 hours.

Half Life

The pharmacokinetic profile of isocarboxazid have not been fully studied but it is suggested that its properties should be fairly similar to the ones of some analogs like phenelzine and tranylcypromine. The isocarboxazid half-life is of little interest as it is an irreversible monoamine oxidase inhibitor. These drugs present a very short half-life of 1.5-4 hours due to rapid hepatic metabolism.

Elimination Route

Most of the eliminated dose is found in the urine, accounting for the 42.5% of the administered dose after 24 hours. From this amount, 75% of the renally eliminated drug is in the form of hippuric acid. Another section of the eliminated dose is observed through the intestinal tract and it accounts for 22% of the administered dose after 24 hours.

Innovators Monograph

You find simplified version here Marplan (PSYCHOANALEPTICS)

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0002448
http://classyfire.wishartlab.com/tax_nodes/C0002279
http://classyfire.wishartlab.com/tax_nodes/C0002279
http://classyfire.wishartlab.com/tax_nodes/C0000081
http://classyfire.wishartlab.com/tax_nodes/C0004144
http://classyfire.wishartlab.com/tax_nodes/C0001165
http://classyfire.wishartlab.com/tax_nodes/C0004140
http://classyfire.wishartlab.com/tax_nodes/C0004139
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0000323
http://classyfire.wishartlab.com/tax_nodes/C0000278
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004150
http://www.hmdb.ca/metabolites/HMDB0015377
http://www.genome.jp/dbget-bin/www_bget?drug:D02580
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3759
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505330
https://www.chemspider.com/Chemical-Structure.3628.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163692
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=6011
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=93635
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1201168
https://zinc.docking.org/substances/ZINC000000001587
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000577
http://www.pharmgkb.org/drug/PA450101
http://www.rxlist.com/cgi/generic/isocarbo.htm
https://www.drugs.com/cdi/isocarboxazid.html
https://en.wikipedia.org/wiki/Isocarboxazid
*** Taking medicines without doctor's advice can cause long-term problems.
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