Martifer
Martifer Uses, Dosage, Side Effects, Food Interaction and all others data.
Martifer interferes with cell metabolism and cell wall synthesis by inhibiting several enzyme systems including acetyl coenzyme A. It is bactericidal to most gram-positive and gram-negative urinary tract pathogens.
Martifer interferes with vital processes in bacteria, which leads to their death. Martifer rapidly reaches therapeutic concentrations in the urine and is also cleared rapidly.
| Trade Name | Martifer |
| Availability | Prescription only |
| Generic | Nitrofurantoin |
| Nitrofurantoin Other Names | 5-Nitrofurantoin, Nitrofurantoin, Nitrofurantoin macrocrystal, Nitrofurantoin macrocrystalline, nitrofurantoina, nitrofurantoine, nitrofurantoinum |
| Related Drugs | amoxicillin, doxycycline, ciprofloxacin, cephalexin, ceftriaxone, levofloxacin, Augmentin, Keflex, sulfamethoxazole / trimethoprim, Bactrim |
| Type | Tablet |
| Formula | C8H6N4O5 |
| Weight | Average: 238.159 Monoisotopic: 238.033819309 |
| Protein binding | Nitrofurantoin could be up to 90% protein bound in plasma. |
| Groups | Approved, Vet approved |
| Therapeutic Class | Systemic Urinary Anti- infective |
| Manufacturer | Unichem Laboratories Ltd |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Martifer is specifically used for the treatment & prophylaxis of urinary tract infections when due to susceptible strains of Escherichia coli, Enterococci, Staphylococcus aureus, Staphylococcus saprophyticus and certain susceptible strains of Klebsiella and Enterobacter species.
Martifer is also used to associated treatment for these conditions: Acute Cystitis, Urinary Tract Infection
How Martifer works
Martifer is converted by bacterial nitroreductases to electrophilic intermediates which inhibit the citric acid cycle as well as synthesis of DNA, RNA, and protein.
Dosage
Martifer dosage
Tablet:
- Adults: 50-100 mg four times a day - the lower dosage level is recommended for uncomplicated urinary tract infections.
- Children: 5-7 mg/kg/day in four divided doses (contraindicated under one month of age). Therapy should be continued for one week or for at least 3 days after sterility of the urine is obtained.
- For long-term suppressive therapy in adults:a reduction of dosage to 50-100 mg at bedtime may be adequate. For long-term suppressive therapy in children, doses as low as 1 mg/kg per 24 hours, given in a single dose or in two divided doses, may be adequate.
SR Capsule:
- Adults and Children over 12 years: One 100 mg capsule every 12 hours for seven days.
- Genito-urinary surgical prophylaxis: One capsule twice daily on day of procedure and for next 3 days.
Suspension:
Children: 5-7 mg/kg/day in four divided doses (contraindicated under 1 month of age). The average dose of Martifersuspension for pediatric patients can be calculated as follows:-
- For 7 to 11 kg Body Weight patient: ½ (2.5 ml) teaspoonfuls (4 times daily)
- For 12 to 21 kg Body Weight patient: 1 (5 ml) teaspoonfuls (4 times daily)
- For 22 to 30 kg Body Weight patient: 1 ½ (7.5 ml) teaspoonfuls (4 times daily)
- For 31 to 41 kg Body Weight patient: 2 (10 ml) teaspoonfuls (4 times daily)
Therapy should be continued for one week or for at least 3 days after sterility of the urine is obtained.
For long-term suppressive therapy in children, doses as low as 1 mg/kg per 24 hours, given in a single dose or in two divided doses, may be adequate.
Martifer should be taken with food.
Side Effects
The most frequent clinical adverse events are nausea, headache, and flatulence. Other less occurred adverse events are diarrhea, dyspepsia, abdominal pain, constipation, emesis, dizziness, drowsiness
Toxicity
Symptoms of overdose include vomiting. In case of overdose, induce vomiting if it has not already occurred and increase fluid intake to promote urination. In extreme cases, nitrofurantoin can be removed from circulation by dialysis.
Precaution
If acute, sub-acute, or chronic pulmonary reactions occur, Martifer should be discontinued. Antacid preparations containing magnesium trisilicate should not be taken while taking Martifer
Interaction
Reduced excretion with probenecid or sulfinpyrazone. Absorption reduced by magnesium trisilicate. Antagonistic effects with quinolone antibacterials. Reduced effects with carbonic anhydrase inhibitors or urinary alkalinisers.
Food Interaction
- Take with food. Food decreases irritation and increases bioavailability.
Martifer Drug Interaction
Moderate: bifidobacterium infantis / lactobacillus acidophilusUnknown: aspirin, diphenhydramine, ubiquinone, duloxetine, apixaban, omega-3 polyunsaturated fatty acids, fluticasone nasal, pregabalin, metoprolol, polyethylene glycol 3350, mirabegron, acetaminophen / hydrocodone, levothyroxine, acetaminophen, cyanocobalamin, ascorbic acid, cholecalciferol, alprazolam, cetirizine
Martifer Disease Interaction
Major: colitis, G-6-PD deficiency, hepatotoxicity, renal dysfunctionModerate: peripheral neuropathy, respiratory
Volume of Distribution
Data regarding the volume of distribution in humans is scarce but it has been reported as 0.46L/kg in dogs.
Elimination Route
Martifer reaches a Cmax of 0.875-0.963mg/L with an AUC of 2.21-2.42mg*h/L. It is 38.8-44.3% bioavailable. Taking nitrofurantoin with food increases the absorption and duration of therapeutic concentrations in the urine.
Half Life
The half life of nitrofurantoin is 0.72-0.78h.
Clearance
The clearance of nitrofurantoin is 16.7-19.4L/h.
Elimination Route
27-50% of an oral dose is excreted in the urine as unchanged nitrofurantoin. 90% of the total dose is eliminated in the urine.
Pregnancy & Breastfeeding use
Pregnancy Category B. There are no adequate and well-controlled studies in pregnant women. This drug should be used during pregnancy only if clearly needed.
Martifer has been detected in human breast milk in trace amounts. Because of the potential for serious adverse reactions from Martifer in nursing infants under one month of age, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother
Contraindication
Anuria, oliguria, or significant impairment of renal function are contraindications. This drug is contraindicated in pregnant patients at 38-42 weeks, during labor and delivery. Martifer is also contraindicated in those patients with known hypersensitivity to Martifer
Acute Overdose
Occasional incidents of acute overdosage of Martifer have not resulted in any specific symptoms other than vomiting. Induction of emesis is recommended
Storage Condition
Store at 15-30° C
Innovators Monograph
You find simplified version here Martifer
Martifer contains Nitrofurantoin see full prescribing information from innovator Martifer Monograph, Martifer MSDS, Martifer FDA label
FAQ
What is Martifer used for?
Martifer is an antibacterial medication used to treat bladder infections, but is not as effective for kidney infections. Martifer is used to treat urinary tract infections.
How safe is Martifer?
Martifer is not suitable for everyone. To make sure it's safe for you, tell your doctor if you have: ever had an allergic reaction to nitrofurantoin or any other medicines in the past. Martifer is effective in the prevention of UTI. Its use may be associated with increased non-severe adverse effects; severe adverse effects occur infrequently. The risk of severe toxicity seems to increase with the duration of Martifer prophylaxis.
How does Martifer work?
Martifer works by killing bacteria or preventing their growth. Martifer kills the bacteria by entering their cells and damaging their genetic material.
What are the common side effects of Martifer?
Common side effects of Martifer are include:
- feeling sick (nausea)
- being sick (vomiting) and diarrhoea.
- loss of appetite.
- headaches.
- dizziness or feeling sleepy.
Is Martifer safe during pregnancy?
It's usually safe to take Martifer during pregnancy . It's very unlikely that Martifer is harmful during pregnancy. It goes straight into your pee, so very little of the medicine passes through to the unborn baby.
Is Martifer safe during breastfeeding?
The use of Martifer in breastfeeding mothers is generally safe, as only small amounts transfer into the breast milk.
Can I drink alcohol with Martifer?
Yes, you can drink alcohol with Martifer.
Can I drive after taking Martifer?
Martifer may cause you to become drowsy, so you should avoid driving when you are taking it. You should also stay away from operating heavy machinery.
When should be taken of Martifer?
Martifer take usually be first thing in the morning, at about midday, late in the afternoon, and at bedtime.
How many time can I take Martifer daily?
Martifer taken twice a day or 50mg taken 4 times a day.
How much Martifer can I take daily?
The usual dose of Martifer to: treat a urinary tract infection is either 100mg taken twice a day or 50mg taken 4 times a day. Severe infections may need a higher dose of 100mg taken 4 times a day.
How long does Martifer take to work?
Martifer should start working within three to five days, although it may take up to a week for symptoms to clear. Be sure to complete the full course of medication.
How long does Martifer stay in my system?
Maximum urinary excretion usually occurs 4-5 hours after administration of macrocrystalline Martifer. Martifer has an elimination half-life of about 30 minutes or less.
Can I take Martifer for a long time?
The Martifer works as well as other long-term antibiotics for preventing recurrent urinary tract infections in women. However gastrointestinal side effects were more common in people on Martifer.
Who should not take Martifer?
You should not take Martifer if you have severe kidney disease, urination problems, or a history of jaundice or liver problems caused by Martifer You also should not take Martifer if you are allergic to it, or if you have, severe kidney disease; a history of jaundice or liver problems caused by taking nitrofurantoin; if you are urinating less than usual or not at all; or if you are in the last 2 to 4 weeks of pregnancy.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happen If I stop taking Martifer?
If you stop taking the Martifer suddenly or don't take it at all: Your urinary tract infection may not go away and may get worse. If you stop taking this Martifer suddenly, the bacteria that caused your urinary tract infection could become resistant to this drug. That means it won't work for you anymore.
What happen If I suddenly stop taking Martifer?
If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include: nausea. vomiting.
Can Martifer affects my heart ?
Elderly patients are more likely to have age-related heart, which may require caution in patients receiving Martifer.
Can Martifer affect my kidneys?
Martifer is a well-known cause of acute renal impairment from acute interstitial nephritis
Can Martifer affects my liver?
Martifer is currently one of the most common causes of drug induced liver injury. Liver injury from Martifer can cause either an acute or chronic hepatitis-like syndrome.
What happens if I take Martifer on an empty stomach?
If taken on an empty stomach, it may cause stomach upset.
