Matro

Matro Uses, Dosage, Side Effects, Food Interaction and all others data.

Matro is a carbonic anhydrase inhibitor. This enzyme catalyzes the reversible reaction involving the hydration of carbon-di-oxide and the dehydration of carbonic acid. In the eye, this inhibitory action of Matro decreases the secretion of aqueous humor and results in a drop in intraocular pressure, a reaction considered desirable in case of glaucoma. Inhibition of carbonic anhydrase in the central nervous system appears to retard abnormal paroxysmal and excessive discharge from central nervous system neurons. So, Matro is also used as an adjuvant in the treatment of epilepsy.

Matro is a potent carbonic anhydrase inhibitor, effective in the control of fluid secretion, in the treatment of certain convulsive disorders and in the promotion of diuresis in instances of abnormal fluid retention. Matro is not a mercurial diuretic. Rather, it is a nonbacteriostatic sulfonamide possessing a chemical structure and pharmacological activity distinctly different from the bacteriostatic sulfonamides.

Trade Name Matro
Availability Prescription only
Generic Acetazolamide
Acetazolamide Other Names Acetazolamid, Acetazolamida, Acétazolamide, Acetazolamide, Acetazolamidum
Related Drugs gabapentin, furosemide, hydrochlorothiazide, clonazepam, spironolactone, lamotrigine, diazepam, pregabalin, Lyrica, topiramate
Type
Formula C4H6N4O3S2
Weight Average: 222.245
Monoisotopic: 221.988131458
Protein binding

98%

Groups Approved, Vet approved
Therapeutic Class Carbonic anhydrase inhibitor
Manufacturer
Available Country Argentina
Last Updated: September 19, 2023 at 7:00 am
Matro
Matro

How Matro works

The anticonvulsant activity of Matro may depend on a direct inhibition of carbonic anhydrase in the CNS, which decreases carbon dioxide tension in the pulmonary alveoli, thus increasing arterial oxygen tension. The diuretic effect depends on the inhibition of carbonic anhydrase, causing a reduction in the availability of hydrogen ions for active transport in the renal tubule lumen. This leads to alkaline urine and an increase in the excretion of bicarbonate, sodium, potassium, and water.

Dosage

Matro dosage

Adults : Initially 250 mg (1 tablet) 4 times daily. Dose should be adjusted later with individual need.

Children : ½ to 2 tablets in divided doses.

In intraocular pressure: 1 tablet 6 hourly. In acute condition, dose should be started with 2 tablets followed by 1 tablet 6 hourly or as directed by the physician

Side Effects

Headache, drowsiness, dizziness, fatigue, anorexia, polyurea, insomnia, gastrointestinal upset.

Food Interaction

  • Drink plenty of fluids.
  • Take with food. Take at least 6 hours before bedtime.

Half Life

3 to 9 hours

Pregnancy & Breastfeeding use

There are no adequate and well controlled studies in pregnant women and neonates. So, Matro should be used with care in those physiological conditions.

Contraindication

Matro is contraindicated in cases of marked kidney and liver diseases or dysfunction, in situations in which sodium and or potassium blood serum levels decreased. Matro is also contraindicated in patients with chronic noncongestive angle closure glaucoma

Innovators Monograph

You find simplified version here Matro

Matro contains Acetazolamide see full prescribing information from innovator Matro Monograph, Matro MSDS, Matro FDA label

*** Taking medicines without doctor's advice can cause long-term problems.
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