Mebeverine hydrochloride
Mebeverine hydrochloride Uses, Dosage, Side Effects, Food Interaction and all others data.
Mebeverine hydrochloride is a musculotropic antispasmodic agent used to relieve cramps or spasms of the stomach and intestine (gut). It is particularly useful in treating Irritable Bowel Syndrome (IBS) and similar conditions. It works by relaxing the muscles and helping to restore the normal movement of the gut.
| Trade Name | Mebeverine hydrochloride |
| Generic | Mebeverine |
| Mebeverine Other Names | Mebeverina, Mebeverine, Mebeverinum |
| Type | |
| Formula | C25H35NO5 |
| Weight | Average: 429.557 Monoisotopic: 429.251523231 |
| Groups | Approved, Investigational |
| Therapeutic Class | Anticholinergics |
| Manufacturer | Aspire Pharma Ltd |
| Available Country | United Kingdom, Netherlands |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the symptomatic treatment of Irritable Bowel Syndrome (IBS) and other conditions include:
- Chronic irritable colon
- Spastic constipation
- Mucous colitis
- Colicky abdominal pain
- Persistent non-specific diarrhea
Mebeverine hydrochloride is also used to associated treatment for these conditions: Abdominal Pain, Abdominal Spasms, Abnormal Bowel Movement Such as Constipation, Diarrhea, Abdominal Pain, Irritable Bowel Syndrome (IBS), Bowel discomfort
Dosage
Mebeverine hydrochloride dosage
135 mg tid, may reduce gradually after several wk when the desired effect has been obtained; 100 mg tid has also been used. As modified-release cap: 200 mg bid.
Mebeverine hydrochloride is most effective when taken 20 minutes before meals. After several weeks when the desired effect has been obtained, the dosage may be gradually reduced.
Missed dose: If a dose of this medicine is missed, that should be taken as soon as possible. However, if it is almost time for the next dose, then skip the missed dose and the regular dosing schedule should be maintained. Dose should not be doubled at the same time to compensate the missed dose.
Side Effects
Generally Mebeverine hydrochloride is well tolerated. However, few side-effects like skin rash, urticaria and angioedema may appear.
Precaution
Caution should be exercised in porphyria or allergic reaction to this or any other medicine of this group.
Food Interaction
No interactions found.Pregnancy & Breastfeeding use
No teratogenicity has been shown in animal experiments. However, the usual precautions concerning the administration of any drug during pregnancy should be exercised. Mebeverine hydrochloride does not excrete in the breast milk after administering the therapeutic dose.
Special Warning
Use in children: Mebeverine hydrochloride is not recommended in children under 10 years.
Acute Overdose
Symptoms: CNS excitability
Management: Symptomatic and supportive treatment. Gastric lavage may be considered in case of multiple intoxication or if discovered w/in approx 1 hr.
Storage Condition
Store below 30° C.
Innovators Monograph
You find simplified version here Mebeverine hydrochloride
Mebeverine hydrochloride contains Mebeverine see full prescribing information from innovator Mebeverine hydrochloride Monograph, Mebeverine hydrochloride MSDS, Mebeverine hydrochloride FDA label
FAQ
What is Mebeverine hydrochloride used for?
Mebeverine hydrochloride helps with muscle spasms. It can be used to ease painful stomach cramps if you have irritable bowel syndrome (IBS) or other conditions.
How safe is Mebeverine hydrochloride?
Mebeverine hydrochloride is generally safe and you're unlikely to have side effects. Some people may get an itchy rash (hives).
How does Mebeverine hydrochloride work?
Mebeverine hydrochloride works by relaxing the muscles in your intestine. This relieves the cramps and pain that can be caused by IBS or other conditions.
What are the common side effects of Mebeverine hydrochloride?
The common side effects of Mebeverine hydrochloride are:
- Nausea.
- Vomiting.
- Rash.
- Headache.
- Heartburn.
- Indigestion.
- Constipation.
- Dizziness.
Is Mebeverine hydrochloride safe during pregnancy?
Mebeverine hydrochloride are not recommended during pregnancy.
Is Mebeverine hydrochloride safe during breastfeeding?
It is usually safe to breastfeed while taking Mebeverine hydrochloride. Some of the medicine may pass into your breast milk. However, this is in small amounts and unlikely to harm your baby.
Can I drink alcohol with Mebeverine hydrochloride?
Yes, you can drink alcohol with Mebeverine hydrochloride.
When should be best taken of Mebeverine hydrochloride?
It's best to take your Mebeverine hydrochloride 20 minutes before a meal.
How often can I take Mebeverine hydrochloride?
The recommended dose is one tablet three times a day. Do not take more than three tablets per day.
Can I Mebeverine hydrochloride take on an empty stomach?
Mebeverine hydrochloride should take on an empty stomach. If you take it twice a day, take it before breakfast and dinner. If you take it 3 times a day, take it before breakfast, lunch and dinner.
How long does Mebeverine hydrochloride take to work?
Mebeverine hydrochloride starts to work after 1 hour. You should feel better 1 to 3 hours after taking it.
What is the half life of Mebeverine hydrochloride?
The steady state elimination half-life of DMAC is 2.45 h.
Does Mebeverine hydrochloride raise blood pressure?
Mebeverine hydrochloride also significantly reduced heart rate and arterial blood pressure.
Can I take Mebeverine hydrochloride for a long time?
You will usually only take Mebeverine hydrochloride if you are having a flare-up of your IBS symptoms.
Who should not take Mebeverine hydrochloride?
The recommended dose is one tablet three times a day. Do not take more than three tablets per day. The number of tablets you take may be lowered if your symptoms improve. Children and adolescents: Mebeverine hydrochloride is not recommended for use in children and adolescents below 18 years of age.
What happen If I missed Mebeverine hydrochloride?
If you miss a dose of Mebeverine hydrochloride, skip the missed dose and take the next one as usual. Do not take a double dose to make up for a missed dose. If you forget doses often, it may help to set an alarm to remind you.
What happens if I take too much Mebeverine hydrochloride?
If you take too much Mebeverine hydrochloride by accident, it is unlikely to harm you. Speak to a pharmacist or doctor if you're worried.
Can I just stop taking Mebeverine hydrochloride?
You can stop taking Mebeverine hydrochloride when you feel better. This may take up to 2 weeks. If you do not get better within 2 weeks of taking Mebeverine hydrochloride, or get worse at any time, talk to a doctor.
Does Mebeverine hydrochloride raise blood pressure?
Mebeverine hydrochloride also significantly reduced heart rate and arterial blood pressure.
Does Mebeverine hydrochloride cause tachycardia?
Transient bradycardia followed by tachycardia.
