Mecillinamum
Mecillinamum Uses, Dosage, Side Effects, Food Interaction and all others data.
Amidinopenicillanic acid derivative with broad spectrum antibacterial action. It is poorly absorbed if given orally and is used in urinary infections and typhus. Mecillinamum is not available in the United States.
Mecillinamum is a novel, semisynthetic penicillin effective against many gram-negative bacteria. The antibacterial activity of amdinocillin is derived from its ability to bind specifically and avidly to Penicillin Binding Protein-2 (PBP 2). Mecillinamum is active alone against many gram-negative organisms. Pseudomonas and non-fermenting gram-negative bacteria, however, are usually resistant. Mecillinamum, in combination with many beta-lactams, exhibits marked synergy against many enterobacteriaceae. No such synergy can be demonstrated for gram-positive organisms or pseudomonas species. Mecillinamum is not beta-lactamase stable. Organisms which produce high levels of plasma-mediated beta-lactamase are resistant to the drug. Co-administration of probenecid results in markedly elevated plasma levels of amdinocillin and delays its excretion.
Trade Name | Mecillinamum |
Generic | Amdinocillin |
Amdinocillin Other Names | Amdinocillin, Mecilinamo, Mecillinam, Mecillinamum, Penicillin HX |
Type | |
Formula | C15H23N3O3S |
Weight | Average: 325.426 Monoisotopic: 325.146012307 |
Groups | Investigational, Withdrawn |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Used in the treatment of urinary tract infections caused by some strains of E. coli and klebsiella and enterobacter species. Used mainly against Gram negative organisms.
How Mecillinamum works
Mecillinamum is a stong and specific antagonist of Penicillin Binding Protein-2 (PBP 2). It is active against gram negative bacteria, preventing cell wall synthesis by inhibiting the activity of PBP2. PBP2 is a peptidoglycan elongation initiating enzyme. Peptidoglycan is a polymer of sugars and amino acids that is the main component of bacterial cell walls.
Elimination Route
Poorly absorbed if given orally.
Half Life
Approximately 1 hour in patients with normal renal function. Increases to 3 to 6 hours in anephric patients.
Innovators Monograph
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