Mecolagin 500 mcg Chewable Tablet Uses, Dosage, Side Effects and more

Mecolagin 500 mcg Chewable Tablet is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.

Attribute	Details
Trade Name	Mecolagin 500 mcg Chewable Tablet
Generic	Mecobalamin
Mecobalamin Other Names	Co-methylcobalamin, MeCbl, Mecobalamin, Mecobalamina, Mecobalaminum, Methyl vitamin B12, Methyl(III)cobalamin, Methylcobalamin
Weight	500 mcg
Type	Chewable Tablet
Formula	C₆₃H₉₁CoN₁₃O₁₄P
Weight	Average: 1344.3823 Monoisotopic: 1343.587806391
Groups	Approved, Investigational
Therapeutic Class	Drugs for Megaloblastic Anemia
Manufacturer	Incepta Pharmaceuticals Ltd.
Available Country	Bangladesh
Last Updated:	January 7, 2025 at 1:49 am

Uses

Mecolagin 500 mcg Chewable Tablet is used for-

Peripheral Neuropathies
Diabetic Neuropathy
Verteberal Syndrome
Nerve Compression Syndrome
Multiple sclerosis
Amyotrophic lateral sclerosis
Parkinson’s disease
Alzheimer’s disease
Diabetic retinopathy
Entrapment neuropathy
Drug induced neuropathy
Megaloblastic anemia due to Vitamin B12 deficiency

Mecolagin 500 mcg Chewable Tablet is also used to associated treatment for these conditions: Vitamin B12 Deficiency, Nutritional supplementation

Dosage

Tablet: The usual adult dosage is one 500 mcg tablet three times daily. The dosage should be adjusted according to the age of patient and the severity of symptoms.

Injection:

Peripheral neuropathies: The usual adult dosage is one ampoule equivalent to 500 mcg of Mecolagin 500 mcg Chewable Tablet, administered intramuscularly or intravenously three times a week.The dosage should be adjusted according to the age of patient and the severity of symptoms.
Megaloblastic anemia: The usual adult dosage is one ampoule equivalent to 500 mcg of Mecolagin 500 mcg Chewable Tablet, administered intramuscularly or intravenously three times a week. After about two months of administration, dosage should be changed to one ampoule equivalent to 500 mcg of Mecolagin 500 mcg Chewable Tablet every one to three months as maintenance therapy

Side Effects

Generally Mecolagin 500 mcg Chewable Tablet is well tolerated. However, a few side effects like GI discomfort (including anorexia, nausea or diarrhea) & rash may be seen after administration of Mecolagin 500 mcg Chewable Tablet.

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Precaution

The medicine should not be used for months if there is no response at all after its use for a certain period of time.

Interaction

Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicine. Reduced serum concentrations with oral contraceptives. Reduced effects in anaemia with parenteral chloramphenicol.

Food Interaction

No interactions found.

Pregnancy & Breastfeeding use

Not recommended during pregnancy & lactation.

Contraindication

Hypersensitivity to any component of this product.

Special Warning

Use in children: Not recommended.

Storage Condition

Oral: Store at room temperature. Protect from moisture and light.

Parenteral: Store at room temperature. Do not expose to direct light.

Innovators Monograph

FAQ

What is Mecolagin 500 mcg Chewable Tablet used for?

Mecolagin 500 mcg Chewable Tablet is used to treat vitamin B12 deficiency.

How safe is Mecolagin 500 mcg Chewable Tablet?

Mecolagin 500 mcg Chewable Tablet is considered likely safe when used appropriately.

How does Mecolagin 500 mcg Chewable Tablet work?

Mecolagin 500 mcg Chewable Tablet works by functioning in the production of a compound called myelin, which covers and protect nerve fibers.

What are the common side effects of Mecolagin 500 mcg Chewable Tablet?

Common side effects of Mecolagin 500 mcg Chewable Tablet are include:

Nausea.
Vomiting.
Diarrhea.
Loss of appetite.
Headache.

Is Mecolagin 500 mcg Chewable Tablet safe during pregnancy?

Pregnancy There are no data available for Mecolagin 500 mcg Chewable Tablet to be used in pregnant women.

Is Mecolagin 500 mcg Chewable Tablet safe during breastfeeding?

There are no data available for Mecolagin 500 mcg Chewable Tablet to be used in lactating women.

Can I drink alcohol with Mecolagin 500 mcg Chewable Tablet?

No interactions were found between Alcohol and Mecolagin 500 mcg Chewable Tablet. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Can I take Mecolagin 500 mcg Chewable Tablet daily?

The recommended dose is 500 mcg three times daily or 1500 mcg daily. Most generic vitamins contain cyanocobalamin, which may not be as effective or as beneficial.

How much Mecolagin 500 mcg Chewable Tablet should I take?

The general recommendation for adults is 2.4 mcg. Older adults, as well as pregnant and breastfeeding women, require higher doses.

Should I take Mecolagin 500 mcg Chewable Tablet on an empty stomach?

It is a well-known medical fact that water-soluble vitamins are better absorbed on an empty stomach. So, the usual time of taking Mecolagin 500 mcg Chewable Tablet will be in the morning as the first dose, half an hour before lunch, and 2 hours post a meal.

How long does Mecolagin 500 mcg Chewable Tablet take to work?

With brisk development of new red blood cells, a response is typically seen within 48 to 72 hours. Mecolagin 500 mcg Chewable Tablet supplies have reached normal levels,Mecolagin 500 mcg Chewable Tablet injections will be required every one to three months to avoid the return of symptoms.

How long does Mecolagin 500 mcg Chewable Tablet supplements stay in my system?

Other studies have shown that Mecolagin 500 mcg Chewable Tablet has a half-life of around six days in the blood, which means that it would take six days before half of the administered amount is excreted from the body

Can Mecolagin 500 mcg Chewable Tablet damage my liver?

There is no evidence that the other B vitamins, in physiologic or even super-physiologic high doses cause liver injury or jaundice.

What are the symptoms of high Mecolagin 500 mcg Chewable Tablet levels?

The study found that high doses of these Mecolagin 500 mcg Chewable Tablet were actually harmful.

Can Mecolagin 500 mcg Chewable Tablet cause kidney stones?

Mecolagin 500 mcg Chewable Tablet have not been shown to be harmful to people with kidney stones.

How long Mecolagin 500 mcg Chewable Tablet can be taken?

Mecolagin 500 mcg Chewable Tablet for 2-4 weeks is associated with better outcome in nerve conduction velocity and neuropathic symptoms.

Who should not take Mecolagin 500 mcg Chewable Tablet?

You should not use Mecolagin 500 mcg Chewable Tablet if you are allergic to Mecolagin 500 mcg Chewable Tablet or cobalt. Tell your doctor if you have ever had Leber's disease or other form of optic nerve damage,an iron or folic acid deficiency.

What happens if I miss a dose of Mecolagin 500 mcg Chewable Tablet?

Use Mecolagin 500 mcg Chewable Tablet as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

Can I overdose on Mecolagin 500 mcg Chewable Tablet?

You cannot overdose on Mecolagin 500 mcg Chewable Tablet because any excess you simply pee out. If you get Mecolagin 500 mcg Chewable Tablet shots, you may experience side effects like dizziness, nausea, and fatigue.