Mederma Stretch Marks Gel 25 gm

Mederma Stretch Marks Gel 25 gm Uses, Dosage, Side Effects, Food Interaction and all others data.

Allantoin is a substance that is endogenous to the human body and also found as a normal component of human diets . In healthy human volunteers, the mean plasma concentration of allantoin is about 2-3 mg/l. During exercise, the plasma allantoin concentration rapidly increases about two fold and remains elevated . In human muscle, urate is oxidized to allantoin during such exercise . The concentration of allantoin in muscles increases from a resting value of about 5000 ug/kg to about 16000 ug/kg immediately after short-term exhaustive cycling exercise .

More specifically, allantoin is a diureide of glyoxylic acid that is produced from uric acid. It is a major metabolic intermediate in most organisms. Allantoin is found in OTC cosmetic products and other commercial products such as oral hygiene products, in shampoos, lipsticks, anti-acne products, sun care products, and clarifying lotions . Allantoin has also demonstrated to ameliorate the wound healing process in some studies .

There is no well controlled and appropriate data that can formally substantiate the pharmacodynamic properties of allantoin . Nevertheless, ongoing studies suggest that allantoin possesses moisturizing and keratolytic effects, as well as abilities to increase the water content of the extracellular matrix and enhance the desquamation of upper layers of dead skin cells, all of which are activities that can promote cell proliferation and facilitate wound healing .

Trade Name Mederma Stretch Marks Gel 25 gm
Generic Cepalin + Allantoin
Weight 25 gm
Type Gel
Therapeutic Class Emollients & combined preparations
Manufacturer Mundipharma (BD) Pvt. Ltd.
Available Country Bangladesh
Last Updated: October 19, 2023 at 6:27 am
Mederma Stretch Marks Gel 25 gm
Mederma Stretch Marks Gel 25 gm

Uses

Relief of dry skin associated with contact dermatitis, senile pruritus, atopic dermatitis, ichthyosis & related dry skin conditions. It softens and hydrates skin. It is also a mild cleanser for dry, sensitive skin. It helps reduce dryness and leaves the skin feeling soft and smooth.

Mederma Stretch Marks Gel 25 gm is also used to associated treatment for these conditions: Scarring, Dental cleaning, Skin Lightening, Skin protection

How Mederma Stretch Marks Gel 25 gm works

There is no well controlled data that can formally substantiate the method of action . However, ongoing studies suggest that there may exist a histological wound healing profile induced by allantoin in rats that leads to the amelioration and fastening of the reestablishment of normal skin . This facilitation of wound healing is supported by observations that wounds inflicted to rat subjects to which topical allantoin preparations were applied histologically demonstrated increased vasodilation, presence of inflammatory exudates, number of inflammatory cells, angiogenesis, fibroblast proliferation, and increased collagen deposition when compared to rat subjects with wounds that did not receive any allantoin administration .

Dosage

Mederma Stretch Marks Gel 25 gm dosage

Mederma Cream should be evenly applied and gently rubbed into the scar 3 times daily for 8 weeks on new scars, and 3 times daily for 3-6 months on existing scars. Also apply Mederma Cream to the scar before sun exposure. Children under 6 months of age: ask a doctor.

Side Effects

Skin irritation in people hypersensitive to any of the ingredients.

Toxicity

No studies on repeated dose toxicity and reproductive toxicity have been submitted. Moreover, studies show that the tumor incidence in allantoin treated animals did not differ largely from that found in untreated controls. As a result, further or additional toxicity, mutagenicity, or carcinogenicity tests are not required in view of the endogenous nature of allantoin and the general lack of overall toxicity .

Finally, as allantoin is a normal component of the diet in humans and is a substance of endogenous origin present in the body of humans, it is generally recognized as being a safe substance for humans .

Precaution

For external use only. When using this product keep out of eyes. Rinse with water to remove. Stop use and ask a doctor if rash or irritation develops and lasts. Do not use on open wounds.

Interaction

There are no known drug interactions and none well documented.

Elimination Route

In studies on human subjects, a recovery of 19% and 34% of allantoin in the urine was observed but only in two individuals and only after the administration of massive doses of allantoin . After intravenous administration, recovery in the urine was practically quantitative with doses of 75 to 600 mgm in the human model . After 240 mgm, excretion continued for 72 hours in human subjects and the results were similar in regards to subcutaneous injection .

Half Life

When studied in cattle, sheep, and horses, the half-life of allantoin is in the range of 1 to 2.5 hours .

Clearance

Some studies suggest that the average renal clearance of allantoin in normal, healthy human subjects is approximately 123 cc per minute . It is generally agreed upon that exogenously administered allantoin is rapidly excreted .

Elimination Route

Urinary clearance is the predominant excretion route .

Pregnancy & Breastfeeding use

Pregnancy Category C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Contraindication

Patients with a history of hypersensitivity to any of the components of the preparation. Acne or greasy skin.

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*** Taking medicines without doctor's advice can cause long-term problems.
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