Mefkind Forte Mango And Honey Flavour
Mefkind Forte Mango And Honey Flavour Uses, Dosage, Side Effects, Food Interaction and all others data.
Mefkind Forte Mango And Honey Flavour, an anthranilic acid derivative, is a prototypical NSAID. It reversibly inhibits the cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2) enzymes, thus resulting in reduced synthesis of prostaglandin precursors. It has analgesic and antipyretic properties with minor anti-inflammatory activity.
Mefkind Forte Mango And Honey Flavour, an anthranilic acid derivative, is a member of the fenamate group of nonsteroidal anti-inflammatory drugs (NSAIDs). It exhibits anti-inflammatory, analgesic, and antipyretic activities. Similar to other NSAIDs, mefenamic acid inhibits prostaglandin synthetase.
| Trade Name | Mefkind Forte Mango And Honey Flavour |
| Generic | Mefenamic acid |
| Mefenamic acid Other Names | Acide méfénamique, ácido mefenámico, Acidum mefenamicum, Mefenamic acid, Mefenaminsäure |
| Type | Suspension |
| Formula | C15H15NO2 |
| Weight | Average: 241.2851 Monoisotopic: 241.110278729 |
| Protein binding | 90% |
| Groups | Approved |
| Therapeutic Class | Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs) |
| Manufacturer | Mankind Pharmaceuticals Ltd |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Mefkind Forte Mango And Honey Flavour is used in mild to moderate pain including headache, dental pain, postoperative and postpartum pain, dysmenorrhoea, menorrhagia, in musculoskeletal and joint disorders such as osteoarthritis and rheumatoid arthritis; and in children with fever and juvenile idiopathic arthritis.
Mefkind Forte Mango And Honey Flavour is also used to associated treatment for these conditions: Mild pain, Primary Dysmenorrhoea, Gastrointestinal cramps, Moderate Pain
How Mefkind Forte Mango And Honey Flavour works
Mefkind Forte Mango And Honey Flavour binds the prostaglandin synthetase receptors COX-1 and COX-2, inhibiting the action of prostaglandin synthetase. As these receptors have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity, the symptoms of pain are temporarily reduced.
Dosage
Mefkind Forte Mango And Honey Flavour dosage
As with other NSAIDs, the lowest dose should be sought for each patient. Therefore, after observing the response to initial therapy with Mefkind Forte Mango And Honey Flavour, the dose and frequency should be adjusted to suit an individual patient's needs.Administration is by the oral route, preferably with food.
- Adult: A 500 mg dose should be given to adults up to three times (1.5 g total) per day.
- Infants over 6 months: 25 mg/kg of body weight daily in divided doses for not longer than 7 days.
Side Effects
In patients taking Mefkind Forte Mango And Honey Flavour or other NSAIDs, the most frequently reported adverse experiences include : abdominal pain, constipation, diarrhoea, dyspepsia, flatulence, gross bleeding/perforation, heartburn, nausea, GI ulcers, vomiting, abnormal renal function, anaemia, dizziness, oedema, elevated liver enzymes, headache, increased bleeding time, pruritus, rash and tinnitus.
Toxicity
Oral, rat LD50: 740 mg/kg. Symptoms of overdose may include severe stomach pain, coffee ground-like vomit, dark stool, ringing in the ears, change in amount of urine, unusually fast or slow heartbeat, muscle weakness, slow or shallow breathing, confusion, severe headache or loss of consciousness.
Precaution
NSAIDs should be prescribed with extreme caution in those with a prior history of ulcer disease or gastrointestinal bleeding. To minimise the potential risk for an adverse GI event, the lowest effective dose should be used for the shortest possible duration. In cases with pre-existing advanced kidney disease, treatment with Mefkind Forte Mango And Honey Flavour is not recommended.
Interaction
Concomitant use with CYP2C9 isoenzyme inhibitors may alter safety and efficacy of mefenamic acid. May enhance methotrexate toxicity. Reduced BP response to ACE inhibitors or angiotensin II receptor antagonists. Increased risk of serious GI events with aspirin. May reduce the natriuretic effects of furosemide or thiazide diuretics. Reduced renal lithium clearance and elevated plasma lithium levels. May enhance anticoagulant effect of warfarin.
Food Interaction
- Avoid alcohol.
- Take with food.
Volume of Distribution
- 1.06 L/kg [Normal Healthy Adults (18-45 yr)]
Elimination Route
Mefkind Forte Mango And Honey Flavour is rapidly absorbed after oral administration.
Half Life
2 hours
Clearance
- Oral cl=21.23 L/hr [Healthy adults (18-45 yrs)]
Elimination Route
The fecal route of elimination accounts for up to 20% of the dose, mainly in the form of unconjugated 3-carboxymefenamic acid.3 The elimination half-life of mefenamic acid is approximately two hours. Mefkind Forte Mango And Honey Flavour, its metabolites and conjugates are primarily excreted by the kidneys. Both renal and hepatic excretion are significant pathways of elimination.
Pregnancy & Breastfeeding use
Pregnancy: In late pregnancy, as with other NSAIDs, Mefkind Forte Mango And Honey Flavour should be avoided because it may cause premature closure of the ductus arteriosus. In general there are no adequate and well controlled studies in pregnant women. Mefkind Forte Mango And Honey Flavour should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus. Rated as Pregnancy Category C.
Lactation: Trace amounts of Mefkind Forte Mango And Honey Flavour may be present in breast milk. Taking into account the importance of the drug to the mother , decision should be made whether to discontinue nursing or to discontinue the drug.
Contraindication
Mefkind Forte Mango And Honey Flavour is contraindicated in patients with known hypersensitivity to Me Mefkind Forte Mango And Honey Flavour acid. Mefkind Forte Mango And Honey Flavour should not be given to patients who have experienced asthma, urticaria, or allergic type reactions after taking aspirin or other NSAIDs. Rarely fatal, anaphylactic like reactions to NSAIDs have been reported in such patients. Mefkind Forte Mango And Honey Flavour is contraindicated in patients with active ulceration or chronic inflammation of upper gastrointestinal tract and should not be used in patients with preexisting renal disease.
Acute Overdose
Symptoms: Headache, nausea, vomiting, epigastric pain, GI bleeding. Rarely, diarrhoea, disorientation, excitation, coma, drowsiness, tinnitus, fainting, and occasionally convulsions.
Management: Symptomatic and supportive treatment. In acute overdosage, empty the stomach immediately by inducing emesis or by gastric lavage followed by admin of activated charcoal.
Storage Condition
Store between 20-25° C.
Innovators Monograph
You find simplified version here Mefkind Forte Mango And Honey Flavour
Mefkind Forte Mango And Honey Flavour contains Mefenamic acid see full prescribing information from innovator Mefkind Forte Mango And Honey Flavour Monograph, Mefkind Forte Mango And Honey Flavour MSDS, Mefkind Forte Mango And Honey Flavour FDA label
FAQ
What is Mefkind Forte Mango And Honey Flavour used for?
Mefkind Forte Mango And Honey Flavour is used short-term to treat mild to moderate pain in adults and children who are at least 14 years old.
How safe is Mefkind Forte Mango And Honey Flavour?
Mefkind Forte Mango And Honey Flavour may increase your risk of heart problems, including heart attack, stroke, heart failure, or blood clot. These conditions can be fatal. Your risk may increase if you already have heart disease or have taken the medication for a long period of time or at high doses.
How does Mefkind Forte Mango And Honey Flavour work?
Mefkind Forte Mango And Honey Flavour works by stopping the body's production of a substance that causes pain, fever, and inflammation.
What are the common side effects of Mefkind Forte Mango And Honey Flavour?
Common side effects of Mefkind Forte Mango And Honey Flavour are include:
- diarrhea.
- constipation.
- gas or bloating.
- headache.
- dizziness.
- nervousness.
- ringing in the ears
Is Mefkind Forte Mango And Honey Flavour safe during pregnancy?
Use of Mefkind Forte Mango And Honey Flavour during pregnancy is not advised unless prescribed by a doctor, especially if you are 30 or more weeks pregnant.
Is Mefkind Forte Mango And Honey Flavour safe during breastfeeding?
Mefkind Forte Mango And Honey Flavour passes into breast milk and is not recommended for use while breastfeeding.
Can I drink alcohol with Mefkind Forte Mango And Honey Flavour?
Do not drink alcohol while taking Mefkind Forte Mango And Honey Flavour. Alcohol can increase your risk of stomach bleeding caused by Mefkind Forte Mango And Honey Flavour. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines.
Can I drive after taking Mefkind Forte Mango And Honey Flavour?
Mefkind Forte Mango And Honey Flavour Tablets may cause drowsiness, fatigue, dizziness or may affect your vision. If you experience any of these symptoms, you should not drive or operate machinery, or perform any tasks which may require you to be alert.
When should be taken of Mefkind Forte Mango And Honey Flavour?
Mefkind Forte Mango And Honey Flavour is usually taken with food every 6 hours as needed for up to 1 week.
Is it safe to take Mefkind Forte Mango And Honey Flavour?
Mefkind Forte Mango And Honey Flavour should not be used for longer than 7 days.
How many times can I take Mefkind Forte Mango And Honey Flavour?
Mefkind Forte Mango And Honey Flavour take 250 mg every six hours as needed. You shouldn't take Mefkind Forte Mango And Honey Flavour for longer than three days.
How long does Mefkind Forte Mango And Honey Flavour take to work?
If you wait until the symptoms have worsened,Mefkind Forte Mango And Honey Flavour may not work as well. If you are using Mefkind Forte Mango And Honey Flavour for painful periods, take your first dose as soon as your period starts or pain begins. Usually, you will only need to take it for the first 2 to 3 days of your period.
How long does it take for Mefkind Forte Mango And Honey Flavour to kick in?
Mefkind Forte Mango And Honey Flavour takes between 2 - 4 hours to kick in and start easing your period pain. Each 500mg dose of Mefkind Forte Mango And Honey Flavour kills pain for up to 8 hours, so you may need to take it two or three times a day for all-day relief.
Can I take Mefkind Forte Mango And Honey Flavour for a long time?
Mefkind Forte Mango And Honey Flavour should not be used for longer than 7 days. Follow your doctor's dosing instructions very carefully. If you use Mefkind Forte Mango And Honey Flavour long-term, you may need frequent medical tests.Mefkind Forte Mango And Honey Flavour can cause unusual results with certain medical tests.
Who should not take Mefkind Forte Mango And Honey Flavour?
Mefkind Forte Mango And Honey Flavour can increase your risk of fatal heart attack or stroke. Do not use Mefkind Forte Mango And Honey Flavour just before or after heart bypass surgery .Mefkind Forte Mango And Honey Flavour may also cause stomach or intestinal bleeding, which can be fatal.
What happens if I miss a dose on Mefkind Forte Mango And Honey Flavour?
Take Mefkind Forte Mango And Honey Flavour as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happen if I take too much Mefkind Forte Mango And Honey Flavour?
If you take too much If you take too much Mefkind Forte Mango And Honey Flavour, you may experience: drowsiness, nausea,vomiting.
When can I stop taking Mefkind Forte Mango And Honey Flavour?
If you experience any of the following symptoms, stop taking Mefkind Forte Mango And Honey Flavour and call your doctor: stomach pain, heartburn, vomit that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools.
Can Mefkind Forte Mango And Honey Flavour affects my heart ?
Mefkind Forte Mango And Honey Flavour can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease.
