Melamix
Melamix Uses, Dosage, Side Effects, Food Interaction and all others data.
Melamix is a topical depigmentating agent that produces a reversible depigmentation of the skin by inhibiting enzymatic oxidation of tyrosine to 3,4-dihydroxyphenylalanine and suppressing melanocyte metabolic processes.
| Trade Name | Melamix |
| Generic | Hydroquinone |
| Hydroquinone Other Names | 1,4-benzenediol, Hydroquinone, Quinol |
| Type | |
| Formula | C6H6O2 |
| Weight | Average: 110.1106 Monoisotopic: 110.036779436 |
| Groups | Approved, Investigational |
| Therapeutic Class | Hydroquinone Preparations |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Melamix is used -
- For the gradual bleaching of hyperpigmented skin conditions such as chloasma, melasma, freckles, senile lentigines and other unwanted areas of melanin hyperpigmentation.
- To reduce hyperpigmentation caused by photosensitization associated with inflammation or with the use of certain cosmetics.
Melamix is also used to associated treatment for these conditions: Acne Vulgaris, Melasma, Skin hyperpigmentation, Moderate Melasma, Severe Melasma
How Melamix works
Melamix reduces melanin pigment production through inhibition of the tyrosinase enzyme, which is involved in the initial step of the melanin pigment biosynthesis pathway. Melamix takes several months to take effect.
Dosage
Melamix dosage
Apply a thin film of Melamix Cream to the effected area once daily, at least 30 minutes before bedtime. Gently wash the face and neck with a mild cleanser. Rinse and pat the skin dry. Apply Melamix Cream to the hyperpigmented areas of melasma including about ½ inch of normal appearing skin surrounding eachlesion. Rub lightly and uniformly into the skin.
Therapy should be discontinued when control is achieved. During the day, use asunscreenof SPF 30, and wear protective clothing. Avoid sunlight exposure. Patients may use moisturizers and/or cosmetics during the day. Melamix Cream is for topical use only. It is not for oral,ophthalmic, or intravaginal use.
Side Effects
No systemic adverse reactions have been reported. Occasional hypersensitivity (localized contact dermatitis) may occur in which case the medication should be discontinued.
Precaution
Melamix is a skin bleaching agent which may produce unwanted cosmetic effects if not used as directed. The physician should be familiar with the contents of this insert before prescribing or dispensing this medication.
Test for skin sensitivity before using by applying a small amount to an unbroken patch of skin to check in 24 hours. Minor redness is not a contraindication, but where there is itching or vesicle formation or excessive inflammatory response, further treatment is not advised. If no bleaching or lightening effect is noted after 2 months of treatment, the medication should be discontinued.
Contact with the eyes and lips should be avoided. Melamix should not be applied to cut or abraded skin.
Food Interaction
No interactions found.Pregnancy & Breastfeeding use
Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Lactation: It is not known whether topical hydroquinone is absorbed or excreted in human milk. Caution is advised when topical hydroquinone is used by a nursing mother.
Contraindication
Melamix is contraindicated to patients with prior history of hypersensitivity or allergic reaction to hydroquinone or other ingredients in the preparation.
Acute Overdose
There have been no systemic reactions from the use of topical hydroquinone. Some patients may experience a transient reddening of skin and mild burning sensation which does not preclude treatment.
Storage Condition
Store between 20-25° C. Protect from light.
Innovators Monograph
You find simplified version here Melamix
Melamix contains Hydroquinone see full prescribing information from innovator Melamix Monograph, Melamix MSDS, Melamix FDA label
FAQ
What is Melamix used for?
Melamix is used to lighten the dark patches of skin (also called hyperpigmentation, melasma, "liver spots," "age spots," freckles) caused by pregnancy, birth control pills, hormone medicine, or injury to the skin. Melamix also known as benzene-1,4-diol or quinol, is an aromatic organic compound that is a type of phenol, a derivative of benzene, having the chemical formula C₆H₄(OH)₂. It has two hydroxyl groups bonded to a benzene ring in a para position.
How safe is Melamix?
Melamix is deemed safe in the United States. There isn't any clinical evidence currently to suggest that Melamix is harmful to humans. However, minor side effects are still possible. It may cause a temporary uptick in redness or dryness at first, especially if you have sensitive skin.
How does Melamix work?
Melamix bleaches your skin by decreasing the number of melanocytes present.
What are the common side effects of Melamix?
Common side effects of Melamix include:
- Mild skin irritation and sensitization (burning, stinging)
- Dermatitis.
- Dryness.
- Redness.
- Inflammatory reaction.
Is Melamix safe during pregnancy?
Whitening and brightening solutions with Melamix are safe to use during pregnancy and won't harm the foetus.
Is Melamix safe during breastfeeding?
Melamix is not contraindicated during breastfeeding and if Melamix is required by the mother, it is not a reason to discontinue breastfeeding. However, some experts feel that long-term use of Melamix is difficult to justify in a nursing mother.
Can Melamix make me blind?
Inhaling Melamix can irritate the nose and throat.
Is Melamix hazardous?
Melamix is also a skin irritant in humans. Chronic (long-term) occupational exposure to Melamix dust can result in eye irritation, corneal effects, and impaired vision.
Can I leave Melamix on overnight?
Apply Melamix cream once daily to clean, dry skin, preferably at bedtime, and leave on overnight.
Can I use Melamix everyday?
Melamix a tyrosinase inhibitor, in a 4% cream can be used safely twice daily for up to 6 months to treat post-inflammatory hyperpigmentation. The efficacy of this treatment can be enhanced by using a retinoid nightly and a mid-potent steroid, which is applied twice daily for 2 weeks, then at weekends only.
How fast does Melamix work?
It takes about four weeks on average for the ingredient to take effect.
How long should I use Melamix?
You can use the product for up to four months, and then begin to taper off use.
Can Melamix be used in the morning?
Apply Melamix in the evening after Retin-A and in the morning for 2 to 6 weeks prior to the procedure.
How often can I use Melamix?
Melamix a tyrosinase inhibitor, in a 4% cream can be used safely twice daily for up to 6 months to treat post-inflammatory hyperpigmentation.
How long does Melamix take to work?
Melamix takes about four weeks on average for the ingredient to take effect.
Can I take Melamix for long time?
You shouldn't use products with this ingredient for more than five months at a time.
When should I stop taking Melamix?
Melamix stop application after five months. If your skin lightens, stop using Melamix regularly and only use it if the dark spots reappear. Wait two or three months to use it in the same areas.
Who should not take Melamix?
Do not use Melamix topical on open wounds or on sunburned, windburned, dry, chapped, or irritated skin. Call your doctor if your symptoms do not improve after 2 months, or if your condition gets worse.
What happens if I miss a dose?
Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.
What happens if I overdose of Melamix?
An overdose of Melamix topical is not expected to be dangerous. Seek emergency medical attention if anyone has accidentally swallowed the medication.
What happen If I stop taking Melamix?
Prolonged regular use of Melamix may lead to exogenous ochronosis, which can cause blue-black pigmentation and papules, red bumps on the skin.
Is Melamix hard on my heart?
Melamix can cause dangerous effects on your heart, especially if you also use certain other medicines. Seek emergency medical attention if you have fast or pounding heartbeats and sudden dizziness
Can Melamix affect my kidneys?
Melamix produce significant histological alterations that might affect the liver and kidney.
Can Melamix affects my liver?
Melamix can remove the top layer of skin, increasing the risk of skin cancer and cause fatal liver and kidney damage.
