Melide

Melide Uses, Dosage, Side Effects, Food Interaction and all others data.

Melide is a nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, anti-pyretic, and analgesic properties. It inhibits prostaglandin synthetase/cyclooxygenase, which limits prostaglandin production. Its cyclooxygenase inhibiting potency is intermediate, but is relatively selective for the cyclo-oxygenase-2 (COX-2) thus the potential for gastric injury and intolerance is less. It is also a free radical scavenger, and helps protect against the tissue damage that occurs during inflammation.

Food, gender and advanced age have negligible effects on nimesulide pharmacokinetics.

Trade Name Melide
Generic Nimesulide
Nimesulide Other Names Nimesulida, Nimesulide, Nimesulidum
Weight 100mg
Type Tablet
Formula C13H12N2O5S
Weight Average: 308.31
Monoisotopic: 308.046692194
Protein binding

>97.5%

Groups Approved, Investigational, Withdrawn
Therapeutic Class Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Manufacturer Ferroza International Pharmaceuticals (pvt) Ltd,
Available Country Pakistan
Last Updated: September 19, 2023 at 7:00 am
Melide
Melide

Uses

Melide is used for acute pain; extra-articular disorders; osteoarthritis; post-op pain; primary dysmenorrhoea

Melide is also used to associated treatment for these conditions: Menstrual Distress (Dysmenorrhea), Pain, Pain, Acute, NSAIDs

How Melide works

The therapeutic effects of Melide are the result of its complete mode of action which targets a number of key mediators of the inflammatory process such as: COX-2 mediated prostaglandins, free radicals, proteolytic enzymes and histamine.

Dosage

Melide dosage

100 mg twice daily.Should be taken with food. Take after meals.

Side Effects

Epigastric discomfort, heartburn or abdominal cramps, nausea, vomiting and diarrhoea; skin rash, pruritus, oedema, headache, dizziness, drowsiness; hypersensitivity reactions (e.g. bronchospasm, rhinitis, angioedema urticaria); GI haemorrhage/perforation; bullous/erosive stomatitis, purpura, thrombocytopenia, toxic epidermal necrolysis, haematuria, oliguria, and renal failure; increases in liver enzymes.

Toxicity

Oral TDLO (human): 1.429 mg/kg; Oral TDLO (woman): 2 mg/kg; Oral LD50 (rat): 200 mg/kg; Oral LD50 (mouse): 392 mg/kg

Precaution

History of GI tract disease, infections, oedema, hypertension, elderly, lactation.

Interaction

Additive hepatotoxic effects with known hepatotoxins: anti-convulsants (e.g. valproic acid), anti-fungals (e.g. ketoconazole), anti-tuberculous drugs (e.g. isoniazid), tacrine, pemoline, amiodarone, methotrexate, methyldopa, amoxicillin/clavulanic acid. May decrease the oral bioavailability of furosemide and the natriuretic and diuretic response to furosemide. Increased risks of GI and hepatic adverse effects with other NSAIDs, including aspirin. May increase anti-coagulant effect of warfarin. Potentiates the action of phenytoin. May be displaced from binding sites with fenofibrate, salicylic acid, and tolbutamide. Interactions between NSAIDs and lithium, probenecid and ciclosporin, have been documented.

Elimination Route

Rapidly absorbed following oral administration.

Half Life

1.8–4.7 hours

Elimination Route

Renal (50%), fecal (29%)

Pregnancy & Breastfeeding use

Category not classified

Contraindication

Hypersensitivity; GI bleeding, active peptic ulcer disease; severe renal and heart failure; hepatic impairment or known liver disease; coagulation disorders; pregnancy; children <12 yr.

Acute Overdose

Epigastric pain, nausea, vomiting, drowsiness, lethargy, GI haemorrhage, seizures, hypertension, apnoea, coma, anaphylactic reactions and renal failure. Treatment is supportive.

Storage Condition

Protect from heat and humidity; store at <25°C.

Innovators Monograph

You find simplified version here Melide

FAQ

What is Melide used for?

Melide is a medication used for pain relief and for the prevention of fever. Acute pain, pain due to menstrual cramps, backache, post-operative pain, osteoarthritis and fever are frequently prescribed.

how safe Melide is?

It is safer to use one with a favourable benefit-harm balance, such as ibuprofen, when a non-steroidal anti-inflammatory drug is required.The drug is best avoided in known or suspected liver disease; caution is warranted while prescribing nimesulide concomitantly with other hepatotoxic drugs.

What are the common side effect of Melide ?

Melide is generally well tolerated, but side effects can include headache, dizziness, somnolence, gastrointestinal upset, nausea, abdominal discomfort, diarrhea, peripheral edema and hypersensitivity reactions.

Is Melide bad for liver?

Melide must be withdrawn worldwide due to serious liver damage.Melide exposes patients to fatal liver damage.

How quickly does Melide work?

Melide works rapidly with immediate onset of action when taken orally. It can effectively reduce pain or fever within 15minutes of taking the medicine.

Is Melide safe during pregnancy?

Our study suggests that the use of Melide in early pregnancy may result in a greater risk of having births with congenital urinary tract anomalies.

Can I take Melide while breastfeeding?

The action of Melide on milk production for infants or the composition of milk is currently unknown. Some studies also suggest that Melide is unsafe for lactating women., lactating women are advised to take medical expert advice, take this drug with precautions, and avoid long-term use.

Can I take Melide safe with alcohol?

Avoid consuming alcohol while taking Melide as it can increase your risk of stomach problems.

Does bnrand increase blood pressure?

Our results indicate no difference between Melide and ketoprofen effects on mean blood pressure values during antihypertensive therapy.

Can Melide be taken empty stomach?

Do not take it on an empty stomach.Always take Melide together with food or immediately after a meal.

Is Melide safe for kidneys?

This observation indicates that Melide can provoke acute renal failure as a result of an obstructive crystalline nephropathy.

Can heart patients take Melide?

Melide should be used with great caution in patients with compromised renal function, cirrhosis of liver, congestive heart failure, renovascular disease, volume or salt depletion.

Is Melide good for headache?

Melide with Paracetamol is used for pain relief.

Is Melide used for migraine?

Melide has a well documented efficacy for relieving symptoms associated with migraine and non-migraine headaches.

Can Melide I take in periods?

Melide reduces the pressure during the maximal but not during the submaximal pain period, with concomitant alleviation of pain. The drug changes the painful state of uterine contracture to painless cyclic contractions.

Can Melide use for ear pain?

Melide indicate that the drug may be an effective and well tolerated therapy for painful inflammatory conditions of the ear, nose and throat.

Can Melide cause sleepiness?

Melide suspension overdose can make you drowsy (feeling sleepy).Generally suspension does not make you feel drowsy. 

Can Melide be used for throat pain?

Melide which may be prescribed by your doctor to get rid of a sore throat and fever if you get these symptoms.

Is Melide safe for adults?

Melide may safe for adult if Melide recommended dose in 100 mg twice daily for no more than 15 days.

How bad is bnand?

Melide must be withdrawn worldwide due to serious liver damage.It exposes patients to fatal liver damage.

Can I take Melide for a long time?

Melide is not recommended long-term, as for chronic conditions such as arthritis. This is due to its association with an increased risk of liver toxicity, including liver failure.

Can I drive after taking Melide?

Melide may cause dizziness. If you feel dizzy, do not drive or take part in any activity in which you need to be alert.

*** Taking medicines without doctor's advice can cause long-term problems.
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