Melovet Plus Bolus(vet)

Melovet Plus Bolus(vet) Uses, Dosage, Side Effects, Food Interaction and all others data.

Melovet Plus Bolus(vet) is an oxicam derivative which exhibits analgesic, antipyretic and anti-inflammatory actions. It reversibly inhibits the cyclooxygenase-1 and -2 (COX-1 and -2) enzymes, thus resulting in reduced synthesis of prostaglandin precursors.

Melovet Plus Bolus(vet) is an anti-inflammatory, analgesic analgesic with antipyretic effects in fever. Prostaglandins are substances that contribute to inflammation. This drug also exerts preferential actions against COX-2, which may reduce the possible gastrointestinal effects of this drug.

In humans, meloxicam has demonstrated the ability to decrease erythrocyte sedimentation rate(ESR) in patients with rheumatoid arthritis, and to decrease ESR, C-reactive protein (CRP), as well as aquaporin-1 expression. As with other NSAIDS, prolonged use of meloxicum can result in renal or cardiovascular impairment or thrombotic cardiovascular events.

A note on gastrointestinal effects

Trade Name Melovet Plus Bolus(vet)
Availability Prescription only
Generic Meloxicam
Meloxicam Other Names Méloxicam, Meloxicam, Meloxicamum
Related Drugs Humira, Buprenex, aspirin, prednisone, ibuprofen, acetaminophen, tramadol, duloxetine, naproxen, Tylenol
Type
Formula C14H13N3O4S2
Weight Average: 351.401
Monoisotopic: 351.034747299
Protein binding

Meloxicam is about 99.4% protein bound, primarily to albumin.

Groups Approved, Vet approved
Therapeutic Class Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Manufacturer Zee Laboratories Ltd
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Melovet Plus Bolus(vet)
Melovet Plus Bolus(vet)

Uses

Melovet Plus Bolus(vet) is used for Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis

Melovet Plus Bolus(vet) is also used to associated treatment for these conditions: Dental Pain, Neuropathic Pain, Osteoarthritis (OA), Pain, Inflammatory, Pauciarticular juvenile rheumatoid arthritis, Polyarticular juvenile rheumatoid arthritis, chronic or unspecified, Postoperative pain, Rheumatoid Arthritis

How Melovet Plus Bolus(vet) works

Melovet Plus Bolus(vet) inhibits prostaglandin synthetase (cylooxygenase 1 and 2) enzymes leading to a decreased synthesis of prostaglandins, which normally mediate painful inflammatory symptoms. As prostaglandins sensitize neuronal pain receptors, inhibition of their synthesis leads to analgesic and inflammatory effects. Melovet Plus Bolus(vet) preferentially inhibits COX-2, but also exerts some activity against COX-1, causing gastrointestinal irritation.

Dosage

Melovet Plus Bolus(vet) dosage

For Adults:

  • Osteoarthritis: 7.5 mg/day. If necessary, in the absence of improvement, the dose may be increased to 15 mg/day.
  • Rheumatoid arthritis: 15 mg/day. In elderly patients the recommended dose for long term treatment is 7.5 mg/day.
  • Ankylosing spondylitis: 15 mg/day. In elderly patients the recommended dose is 7.5 mg/day.

Do not exceed the dose of 15 mg/day. The total daily amount should be taken as a single dose. Patients with increased risks for adverse reactions should start treatment with 7.5 mg/day. In dialysis patients with severe renal failure the dose should not exceed 7.5 mg/day

For Children: The pharmacokinetics of Melovet Plus Bolus(vet) in paediatric patients under 18 years of age have not been investigated.

Side Effects

Nausea, vomiting, abdominal pain, dyspepsia, constipation or diarrhoea may occur. Ulcers or gastrointestinal bleeding may rarely occur. Skin rash, or urticaria may occur in some individuals. Oedema of the lower limbs may occur during treatment. Onset of an asthma attack has been reported in certain individuals allergic to aspirin or to other NSAIDs. Headache, vertigo or drowsiness may occur.

Toxicity

The oral LD50 in rats is 98 mg/kg. Signs and symptoms of overdose with meloxicam may include shallow breathing, seizure, decreased urine output, gastrointestinal irritation, nausea, vomiting, gastrointestinal bleeding, and black tarry stools. In the case of an overdose, offer supportive treatment and attempt to remove gastrointestinal contents. Cholestyramine has been shown to enhance the elimination of meloxicam.

Precaution

Patient with known CV disease or risk factors for CV disease, fluid retention or heart failure, history of GI bleeding or ulceration. Hepatic and renal impairment. Elderly. Pregnancy and lactation.

Interaction

Other NSAIDs, including high doses of salicylates: Administration of several NSAIDs together may increase the risk of ulcers and of gastrointestinal bleeding, via a synergistic effect.

Oral anticoagulants, heparin and ticlopidine: Increased risk of bleeding via inhibition of platelet function and damage to the gastroduodenal mucosa. Careful monitoring of the effects of anticoagulants is thus essential if it proves impossible to avoid such combined prescription.

Lithium: NSAIDs increase blood lithium levels, which may then reach toxic values.

Methotrexate: NSAIDs may accentuate the haematologic toxicity of methotrexate.

Intrauterine contraceptive devices: NSAIDs appear to decrease the efficacy of intrauterine contraceptive devices.

Food Interaction

  • Avoid alcohol. The risk of gastrointestinal bleeding may be increased.
  • Take with or without food. The absorption is unaffected by food.

Melovet Plus Bolus(vet) Alcohol interaction

[Moderate] GENERALLY AVOID:

The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss.

The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.



Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.

Melovet Plus Bolus(vet) Hypertension interaction

[Major] Fluid retention and edema have been reported in association with the use of nonsteroidal anti-inflammatory drugs (NSAIDs).

Therapy with NSAIDs should be administered cautiously in patients with preexisting fluid retention, hypertension, or a history of heart failure.

Blood pressure and cardiovascular status should be monitored closely during the initiation of NSAID treatment and throughout the course of therapy.

Hypertension interaction

[Moderate] Nonsteroidal anti-inflammatory drugs (NSAIDs), including topicals, can lead to new onset of hypertension or worsening of preexisting hypertension, either of which can contribute to the increased incidence of cardiovascular events.

NSAIDs should be used with caution in patients with hypertension.

Blood pressure should be monitored closely during the initiation of NSAID therapy and throughout the course of therapy.

Volume of Distribution

The volume of distribution of meloxicam is 10-15L. Because of its high binding to albumin, it is likely to be distributed in highly perfused tissues, such as the liver and kidney. Melovet Plus Bolus(vet) concentrations in synovial fluid, measured after an oral dose, is estimated at 40% to 50% of the concentrations measured in the plasma. This drug is known to cross the placenta in humans.

Elimination Route

The absolute bioavailability oral capsules after a dose was 89% in one pharmacokinetic study. Cmax was reached 5–6 hours after administration of a single dose given after the first meal of the day. The Cmax doubled when the drug was administered in the fasting state. Despite this, meloxicam can be taken without regard to food, unlike many other NSAIDS.

Melovet Plus Bolus(vet) formulated for instillation with bupivacaine produced varied systemic measures following a single dose of varying strength. In patients undergoing bunionectomy, 1.8 mg of meloxicam produced a Cmax of 26 ± 14 ng/mL, a median Tmax of 18 h, and an AUC of 2079 ± 1631 ng*h/mL. For a 9 mg dose used in herniorrhaphy, the corresponding values were 225 ± 96 ng/mL, 54 h, and the AUC was not reported. Lastly, a 12 mg dose used in total knee arthroplasty produced values of 275 ± 134 ng/mL, 36 h, and 25,673 ± 17,666 ng*h/mL.

Half Life

The half-life of meloxicam is approximately 20 hours, which is considerably longer than most other NSAIDS. It can therefore be dosed without the need for slow-release formulations.

Melovet Plus Bolus(vet) applied together with bupivacaine for postsurgical analgesia had a median half-life of 33-42 hours, depending on dose and application site.

Clearance

After an oral dose, the total clearance of meloxicam is 0.42–0.48 L/h. The FDA label indicates a plasma clearance from 7 to 9 mL/min. No dose changes are required in mild to moderate renal or hepatic impairment. The use of meloxicam in patients with severe renal or hepatic impairment has not been studied. FDA prescribing information advises against it.

Elimination Route

Melovet Plus Bolus(vet) is mainly eliminated through metabolism. Its metabolites are cleared through renal and fecal elimination. Less than 10 About 1.6% of the parent drug is excreted in the feces.

Pregnancy & Breastfeeding use

Pregnancy: It is advisable to avoid the administration of Melovet Plus Bolus(vet) during pregnancy.

Lactation: It is unknown whether Melovet Plus Bolus(vet) passes into mother’s milk. Melovet Plus Bolus(vet) should not be given to nursing mothers.

Contraindication

Melovet Plus Bolus(vet) is contraindicated to patients hypersensitive to this drug. Melovet Plus Bolus(vet) should not be given to patients who have developed signs of asthma, nasal polyps, angioneurotic oedema or urticaria following the administration of aspirin or NSAIDs. Melovet Plus Bolus(vet) is contraindicated to patients with active peptic ulcer during the last six months or a history of recurrent peptic ulcer disease, severe hepatic failure, non-dialysed severe renal failure, gastrointestinal bleeding, cerebrovascular bleeding or other bleeding disorders.

Acute Overdose

Symptoms: Lethargy, drowsiness, nausea, vomiting, epigastric pain, GI bleeding; severe symptoms (e.g. HTN, hepatic dysfunction, resp depression, convulsions, CV collapse, cardiac arrest, coma, acute renal failure).

Management: Supportive and symptomatic treatment. Admin of activated charcoal 1-2 hr after ingestion.

Storage Condition

Store Melovet Plus Bolus(vet) tablet in a cool & dry place and away from light. Store Melovet Plus Bolus(vet) suppository below 25˚C protected from light and moisture.

Innovators Monograph

You find simplified version here Melovet Plus Bolus(vet)

Melovet Plus Bolus(vet) contains Meloxicam see full prescribing information from innovator Melovet Plus Bolus(vet) Monograph, Melovet Plus Bolus(vet) MSDS, Melovet Plus Bolus(vet) FDA label

FAQ

What is Melovet Plus Bolus(vet) used for?

Melovet Plus Bolus(vet) is used to treat the symptoms of osteoarthritis and rheumatoid arthritis. Both diseases mainly affect the joints causing pain and swelling. Although MOXICAM can relieve symptoms such as pain and inflammation, it will not cure your condition.

What does Melovet Plus Bolus(vet) do for the body?

Melovet Plus Bolus(vet) is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by stopping the body's production of a substance that causes pain, fever, and inflammation.

How long does Melovet Plus Bolus(vet) stay in my system?

The elimination half-life of Melovet Plus Bolus(vet) (or the duration of time it takes your body to metabolize and get rid of half of the drug in your system) is about 20 hours. However, this varies from person to person. Melovet Plus Bolus(vet) can also be detected by a urine drug test for up to five days after the last dose.

Does Melovet Plus Bolus(vet) make me sleepy?

The side effects for Melovet Plus Bolus(vet) don't mention drowsiness (actually Melovet Plus Bolus(vet) can cause insomnia) but does mention dizziness. But headache is a common, less serious side effect of Melovet Plus Bolus(vet).

What is the best time to take Melovet Plus Bolus(vet)?

Take each dose with a snack or just after eating a meal and drink plenty of water whilst on Melovet Plus Bolus(vet). If your doctor has prescribed melt-in-the-mouth (orodispersible) tablets: Moisten your mouth first, taking a sip of water if needed. Remove the tablet from the packaging, taking care not to moisten it.

Is Melovet Plus Bolus(vet) good for pain?

Melovet Plus Bolus(vet) is used to treat arthritis. It reduces pain, swelling, and stiffness of the joints. Melovet Plus Bolus(vet) is known as a nonsteroidal anti-inflammatory drug (NSAID).

How long does it take for Melovet Plus Bolus(vet) to relieve pain?

Melovet Plus Bolus(vet) can take up to two weeks to start working in full effect. Some changes to pain, swelling, tenderness, or stiffness may be noticeable within 24 to 72 hours, but it might take longer to notice a large difference in pain levels.

Who should not take Melovet Plus Bolus(vet)?

If you have the following condition you should not take Melovet Plus Bolus(vet):

  • systemic mastocytosis
  • anemia
  • increased risk of bleeding due to clotting disorder
  • an increased risk of bleeding
  • alcoholism
  • high blood pressure
  • a heart attack
  • chronic heart failure
  • abnormal bleeding in the brain resulting in damage to brain tissue, called a hemorrhagic stroke
  • a blood clot
  • stomach or intestinal ulcer
  • bleeding of the stomach or intestines
  • kidney transplant
  • visible water retention
  • abnormal liver function tests
  • pregnancy
  • a rupture in the wall of the stomach or intestine
  • tobacco smoking
  • increased cardiovascular event risk
  • time immediately after coronary bypass surgery
  • chronic kidney disease
  • kidney disease with likely reduction in kidney function
  • aspirin exacerbated respiratory disease
  • history of gastric bypass surgery
  • history of kidney donation

Is Melovet Plus Bolus(vet) a muscle relaxer?

Melovet Plus Bolus(vet) is used to treat arthritis. It reduces pain, swelling, and stiffness of the joints.

Does Melovet Plus Bolus(vet) cause high blood pressure?

Melovet Plus Bolus(vet) may increase or worsen your blood pressure. This can increase your risk of heart attack or stroke. Your doctor may check your blood pressure while you're taking Melovet Plus Bolus(vet).

Can you take vitamins with Melovet Plus Bolus(vet)?

No interactions were found between Melovet Plus Bolus(vet) and Vitamin D3. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Why is Melovet Plus Bolus(vet) bad for me?

Melovet Plus Bolus(vet) can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Even people without heart disease or risk factors could have a stroke or heart attack while taking this medicine.

Can Melovet Plus Bolus(vet) hurt kidneys?

It is possible to develop kidney damage from taking Melovet Plus Bolus(vet). However, drug-induced kidney damage is often reversible if the drug causing it is stopped. Melovet Plus Bolus(vet) use can also lead to liver damage.

Is Melovet Plus Bolus(vet) bad for heart?

Melovet Plus Bolus(vet) can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Melovet Plus Bolus(vet) may also cause stomach or intestinal bleeding, which can be fatal.

How does Melovet Plus Bolus(vet) work?

Melovet Plus Bolus(vet) works by blocking the effects of the enzymes cyclooxygenase (COX)-1 and COX-2 which prevents prostaglandin synthesis. Prostaglandins elevate body temperature and make nerve endings more sensitive to pain transmission.

Is it OK to stop taking Melovet Plus Bolus(vet) suddenly?

Although Melovet Plus Bolus(vet) does not cause a withdrawal syndrome, because Melovet Plus Bolus(vet) is used for the treatment of pain and inflammation anyone who suddenly stops taking the medication may experience the return of their pain or inflammation.

What are the side effects of Melovet Plus Bolus(vet)?

The more common side effects that can occur with Melovet Plus Bolus(vet) include:

  • abdominal pain.
  • diarrhea.
  • indigestion or heartburn.
  • nausea.
  • dizziness.
  • headache.
  • itching or rash.


What are the side effects of long term use of Melovet Plus Bolus(vet)?

Melovet Plus Bolus(vet) can cause long-term harm. All medications have potential side effects. Long-term use of NSAIDs may increase the risk of stomach or intestinal bleeding, ulcers, or holes. Long-term use of non-aspirin NSAIDs may increase the risk of heart attack or stroke.

Is Melovet Plus Bolus(vet) safe in pregnancy?

Use of Melovet Plus Bolus(vet) during pregnancy is not advised unless prescribed by your doctor, especially if you are 30 or more weeks pregnant. Paracetamol is usually recommended to control pain or fever during pregnancy.

Is Melovet Plus Bolus(vet) safe during breastfeeding?

It isn't known if Melovet Plus Bolus(vet) passes into breast milk. Because no information is available on the use of Melovet Plus Bolus(vet) during breastfeeding, other agents may be preferred, especially while nursing a newborn or preterm infant.

Can I lay down after taking Melovet Plus Bolus(vet)?

Do not lie down for at least 10 minutes after taking Melovet Plus Bolus(vet). If you are taking the liquid form of this medication, shake the bottle gently before each dose.

*** Taking medicines without doctor's advice can cause long-term problems.
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