Melperone

Melperone Uses, Dosage, Side Effects, Food Interaction and all others data.

Melperone is an atypical antipsychotic of the butyrophenone chemical class, making it structurally related to the typical antipsychotic haloperidol. Melperone has been used for a span of greater than 30 years in the European Union . It has been well established in the treatment of confusion, anxiety, restlessness (particularly in the elderly) and schizophrenia as It is known to be well-tolerated with an excellent safety profile. Recently, it has been studied as a treatment of psychosis related to Parkinson's disease .

Melperone has been demonstrated to produce an antipsychotic effect at doses that cause minimal extrapyramidal symptoms frequently associated with more traditional antipsychotics .

Melperone
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Uses during Pregnancy
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Trade Name	Melperone
Generic	Melperone
Melperone Other Names	Melperone
Type
Formula	C₁₆H₂₂FNO
Weight	Average: 263.356 Monoisotopic: 263.168542495
Protein binding	Melperone has a bioavailability of 50-70% [A3145].
Groups	Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Melperone is an atypical butyrophenone antipsychotic used to treat sleep disorders, confusion, and psychomotor dysfunction associated with geriatric, psychiatric, and alcohol-dependent patients.

For the treatment of schizophrenia, sleep, disorders, agitation and mentally confused states .

Melperone is also used to associated treatment for these conditions: Confusion, Congenital Dementias, Neurotic Disorders, Psychosis, Sleep Disorder, Psychomotor restlessness

How Melperone works

Melperone demonstrates antagonist activity at D2 dopaminergic and 5HT2A serotonergic receptors . It has a weak affinity to D2 receptors and possesses less risk of inducing dopamine receptor supersensitivity after both acute and chronic administration [L3146]. In addition, the ratio of dopamine D4/D2 occupancy for melperone has been shown to resemble the binding profile of clozapine .