Mephentine
Mephentine Uses, Dosage, Side Effects, Food Interaction and all others data.
A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1248)
Mephentine is a sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1248)
| Trade Name | Mephentine |
| Availability | Discontinued |
| Generic | Mephentermine |
| Mephentermine Other Names | Mefentermina, Mephentermine, Mephenterminum |
| Weight | 15mg, , 30mg |
| Type | Injection, Tablet |
| Formula | C11H17N |
| Weight | Average: 163.2594 Monoisotopic: 163.136099549 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | Pfizer Ltd, Wyeth Pharmaceuticals Limited |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Mephentine is a sympathomimetic agent used in the treatment of hypotension.
Used to maintain blood pressure in hypotensive states.
How Mephentine works
Mephentine is an alpha adrenergic receptor agonist, but also acts indirectly by releasing endogenous norepinephrine. Cardiac output and systolic and diastolic pressures are usually increased. A change in heart rate is variable, depending on the degree of vagal tone. Sometimes the net vascular effect may be vasodilation. Large doses may depress the myocardium or produce central nervous system (CNS) effects.
Mephentine Drug Interaction
Moderate: amphetamine / dextroamphetamine, amphetamine / dextroamphetamine, dapagliflozin, dapagliflozinUnknown: alemtuzumab, alemtuzumab, rosuvastatin, rosuvastatin, abobotulinumtoxinA, abobotulinumtoxinA, fentanyl, fentanyl, ziprasidone, ziprasidone, ergoloid mesylates, ergoloid mesylates, chlorpheniramine / hydrocodone / phenylephrine, chlorpheniramine / hydrocodone / phenylephrine, desogestrel / ethinyl estradiol, desogestrel / ethinyl estradiol
Mephentine Disease Interaction
Half Life
17 to 18 hours.
Innovators Monograph
You find simplified version here Mephentine
