Mephentine

Mephentine Uses, Dosage, Side Effects, Food Interaction and all others data.

A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1248)

Mephentine is a sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1248)

Trade Name Mephentine
Availability Discontinued
Generic Mephentermine
Mephentermine Other Names Mefentermina, Mephentermine, Mephenterminum
Weight 15mg, , 30mg
Type Injection, Tablet
Formula C11H17N
Weight Average: 163.2594
Monoisotopic: 163.136099549
Groups Approved
Therapeutic Class
Manufacturer Pfizer Ltd, Wyeth Pharmaceuticals Limited
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Mephentine
Mephentine

Uses

Mephentine is a sympathomimetic agent used in the treatment of hypotension.

Used to maintain blood pressure in hypotensive states.

How Mephentine works

Mephentine is an alpha adrenergic receptor agonist, but also acts indirectly by releasing endogenous norepinephrine. Cardiac output and systolic and diastolic pressures are usually increased. A change in heart rate is variable, depending on the degree of vagal tone. Sometimes the net vascular effect may be vasodilation. Large doses may depress the myocardium or produce central nervous system (CNS) effects.

Mephentine Disease Interaction

Major: dehydrationModerate: acidosis

Half Life

17 to 18 hours.

Innovators Monograph

You find simplified version here Mephentine

*** Taking medicines without doctor's advice can cause long-term problems.
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