Mepisolver

Mepisolver Uses, Dosage, Side Effects, Food Interaction and all others data.

A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepisolver is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)

Mepivicaine is an amide local anesthetic. Mepivicaine as a reasonably rapid onset and medium duration and is known by the proprietary names as Carbocaine and Polocaine. Mepivicaine is used in local infiltration and regional anesthesia. Systemic absorption of local anesthetics produces effects on the cardiovascular and central nervous systems. At blood concentrations achieved with normal therapeutic doses, changes in cardiac conduction, excitability, refractoriness, contractility, and peripheral vascular resistance are minimal.

Trade Name Mepisolver
Availability Prescription only
Generic Mepivacaine
Mepivacaine Other Names DL-Mepivacaine, Mepivacaina, Mepivacaine, Mepivacainum
Related Drugs lidocaine ophthalmic, cocaine nasal, bupivacaine
Type
Formula C15H22N2O
Weight Average: 246.348
Monoisotopic: 246.173213336
Protein binding

Mepivacaine is approximately 75% bound to plasma proteins. Generally, the lower the plasma concentration of drug, the higher the percentage of drug bound to plasma.

Groups Approved, Vet approved
Therapeutic Class
Manufacturer
Available Country Italy
Last Updated: September 19, 2023 at 7:00 am
Mepisolver
Mepisolver

Uses

Mepisolver is a local anesthetic used for local or regional analgesia or anesthesia.

For production of local or regional analgesia and anesthesia by local infiltration, peripheral nerve block techniques, and central neural techniques including epidural and caudal blocks.

Mepisolver is also used to associated treatment for these conditions: Anaemia vitamin B6 deficiency, Anemia, Blood Loss Anemia, Diabetic Peripheral Neuropathy (DPN), Regional nerve block therapy, Local anesthesia therapy, Lumbar epidural anesthesia therapy

How Mepisolver works

Local anesthetics block the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. In general, the progression of anesthesia is related to the diameter, myelination, and conduction velocity of affected nerve fibers. Clinically, the order of loss of nerve function is as follows: pain, temperature, touch, proprioception, and skeletal muscle tone.

Toxicity

The mean seizure dosage of mepivacaine in rhesus monkeys was found to be 18.8 mg/kg with mean arterial plasma concentration of 24.4 µg/mL. The intravenous and subcutaneous LD 50 in mice is 23 mg/kg to 35 mg/kg and 280 mg/kg respectively.

Food Interaction

No interactions found.

Mepisolver Disease Interaction

Moderate: arrhythmias

Elimination Route

Absorbed locally. The rate of systemic absorption of local anesthetics is dependent upon the total dose and concentration of drug administered, the route of administration, the vascularity of the administration site, and the presence or absence of epinephrine in the anesthetic solution.

Half Life

The half-life of mepivacaine in adults is 1.9 to 3.2 hours and in neonates 8.7 to 9 hours.

Elimination Route

It is rapidly metabolized, with only a small percentage of the anesthetic (5 percent to 10 percent) being excreted unchanged in the urine.The liver is the principal site of metabolism, with over 50% of the administered dose being excreted into the bile as metabolites.

Innovators Monograph

You find simplified version here Mepisolver

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https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:6759
http://www.hmdb.ca/metabolites/HMDB0015096
http://www.genome.jp/dbget-bin/www_bget?drug:D08181
http://www.genome.jp/dbget-bin/www_bget?cpd:C07528
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4062
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507857
https://www.chemspider.com/Chemical-Structure.3922.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50417964
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=6759
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=6759
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1087
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP001232
http://www.pharmgkb.org/drug/PA164748741
http://www.rxlist.com/cgi/generic2/mepivacaine.htm
https://www.drugs.com/cdi/mepivacaine.html
https://en.wikipedia.org/wiki/Mepivacaine
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