meriscan
meriscan Uses, Dosage, Side Effects, Food Interaction and all others data.
The paramagnetic properties of meriscan provides contrast enhancement during MRI. There were no clinically significant deviations from pre-injection values in haemodynamic and blood and urine laboratory parameters following intravenous injection of gadodiamide in healthy volunteers. However, a minor transient change in serum iron levels 8 to 48 hours after gadodiamide injection was observed.
meriscan does not cross the intact blood-brain barrier. Administration of meriscan causes signal enhancement from areas where blood-brain barrier dysfunction has been induced by pathological processes, and may provide greater diagnostic yield than unenhanced MRI. Lack of enhancement need not indicate absence of pathology since some types of low grade malignancies or inactive MS-plaques fail to enhance; it can be used for differential diagnosis between different pathologies.
Trade Name | meriscan |
Availability | Prescription only |
Generic | Gadodiamide |
Gadodiamide Other Names | Gadodiamida, Gadodiamide |
Related Drugs | Dotarem, gadobutrol, Magnevist, Gadavist, Clariscan, Omniscan, gadopentetate dimeglumine |
Weight | 0.5mmol/ml |
Type | Solution |
Formula | C16H26GdN5O8 |
Weight | Average: 573.66 Monoisotopic: 574.10225 |
Groups | Approved, Investigational |
Therapeutic Class | Contrast medium for diagnostic procedures |
Manufacturer | Tabuk Pharmaceutical Manufacturing Co, |
Available Country | Saudi Arabia |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
CNS (Central Nervous System): meriscan is a gadolinium-based contrast agent used for intravenous use in MRI to visualize lesions with abnormal vascularity (or those thought to cause abnormalities in the blood-brain barrier) in the brain (intracranial lesions), spine, and associated tissues.
Body (Intrathoracic [noncardiac], Intra-abdominal, Pelvic And Retroperitoneal Regions): meriscan is a gadolinium-based contrast agent used for intravenous use in MRI to facilitate the visualization of lesions with abnormal vascularity within the thoracic (noncardiac), abdominal, pelvic cavities, and the retroperitoneal space.
How meriscan works
Based on the behavior of protons when placed in a strong magnetic field, which is interpreted and transformed into images by magnetic resonance (MR) instruments. Paramagnetic agents have unpaired electrons that generate a magnetic field about 700 times larger than the proton's field, thus disturbing the proton's local magnetic field. When the local magnetic field around a proton is disturbed, its relaxation process is altered. MR images are based on proton density and proton relaxation dynamics. MR instruments can record 2 different relaxation processes, the T1 (spin-lattice or longitudinal relaxation time) and the T2 (spin-spin or transverse relaxation time). In magnetic resonance imaging (MRI), visualization of normal and pathological brain tissue depends in part on variations in the radiofrequency signal intensity that occur with changes in proton density, alteration of the T1, and variation in the T2. When placed in a magnetic field, gadodiamide shortens both the T1 and the T2 relaxation times in tissues where it accumulates. At clinical doses, gadodiamide primarily affects the T1 relaxation time, thus producing an increase in signal intensity. meriscan does not cross the intact blood-brain barrier; therefore, it does not accumulate in normal brain tissue or in central nervous system (CNS) lesions that have not caused an abnormal blood-brain barrier (e.g., cysts, mature post-operative scars). Abnormal vascularity or disruption of the blood-brain barrier allows accumulation of gadodiamide in lesions such as neoplasms, abscesses, and subacute infarcts.
Dosage
meriscan dosage
No special preparation of the patient is required. meriscan should be drawn into the syringe immediately before use.The vial is intended for one patient only. Contrast medium not used in one examination must be discarded. CNS (Central Nervous System):
- Adults: The recommended dose of meriscan is 0.2 mL/kg (0.1 mmol/kg) administered as a bolus intravenous injection.
- Pediatric Patients (2-16 years): The recommended dose of meriscan is 0.2 mL/kg (0.1 mmol/kg) administered as a bolus intravenous injection.
Body (Intrathoracic [noncardiac], Intra-abdominal, Pelvic And Retroperitoneal Regions):
- Adult and Pediatric Patients (2-16 years of age): For imaging the kidney, the recommended dose of meriscan is 0.1 mL/kg (0.05 mmol/kg). For imaging the intrathoracic (noncardiac), intra-abdominal, and pelvic cavities, the recommended dose of meriscan is 0.2 mL/kg (0.1 mmol/kg)
Side Effects
Nephrogenic systemic fibrosis, Hypersensitivity reactions
Precaution
Gadolinium-based contrast agents (GBCAs) increase the risk for nephrogenic systemic fibrosis (NSF) among patients with impaired elimination of the drugs. Avoid use of GBCAs among these patients unless the diagnostic information is essential and not available with non-contrast enhanced MRI or other modalities.
The GBCA-associated NSF risk appears highest for patients with chronic, severe kidney disease (GFR < 30 mL/min/1.73m2) as well as patients with acute kidney injury. Screen patients for acute kidney injury and other conditions that may reduce renal function.
Interaction
There are no known drug interactions and none well documented.
Food Interaction
No interactions found.meriscan Hypertension interaction
[Major] Gadolinium- based contrast agents (GBCAs) such as gadopentetate dimeglumine, gadoteridol and gadodiamide are contraindicated in patients with chronic, severe kidney disease (glomerular filtration rate, GFR 60 years, hypertension or diabetes).
Always estimate the glomerular filtration rate (GFR) through laboratory testing.
meriscan Drug Interaction
Unknown: aspirin, aspirin, amoxicillin, amoxicillin, amoxicillin / clavulanate, amoxicillin / clavulanate, celecoxib, celecoxib, ciprofloxacin, ciprofloxacin, deferoxamine, deferoxamine, ginkgo, ginkgo, acetaminophen, acetaminophen, tamoxifen, tamoxifen
meriscan Disease Interaction
Volume of Distribution
- 200 ± 61 mL/kg
Half Life
Two-compartment model with mean distribution and elimination half-lives (reported as mean ± SD) of 3.7 ± 2.7 minutes and 77.8 ± 16 minutes, respectively.
Clearance
- Renal cl=1.7 mL/min/kg
- Plasma cl=1.8 mL/min/kg
Elimination Route
meriscan is eliminated primarily in the urine.
Pregnancy & Breastfeeding use
Pregnancy category B3. No effects of meriscan on reproductive performance were seen in rats at doses up to 1.0 mmol/kg. In rabbits, there is an increased incidence of litters with skeletal or visceral abnormalities at doses up to 0.5 and 1.0 mmol/kg. However, these effects are possibly attributable to maternal toxicity rather than a direct effect of the drug. There are no adequate and well-controlled studies of meriscan in pregnant women. meriscan should be used in pregnancy only if the potential benefit justifies the potential risk to the foetus.
Use in Lactation: It is not known whether meriscan is excreted in human milk. Breast-feeding should be discontinued prior to administration and should not be recommenced until at least 24 hours after the administration of meriscan.
Contraindication
Chronic, severe kidney disease (glomerular filtration rate < 30 ml/ min/1.73 m2), or acute kidney injury prior hypersensitivity reaction, should not be used in patients known to have hypersensitivity to meriscan or its constituents.
Special Warning
Use in Children: The safety and effectiveness of meriscan have been established for whole body magnetic resonance imaging in children from 6 months of age.The safety and effectiveness in infants and neonates have been established in the evaluation of lesions within the brain and spine.
There is no experience with meriscan in children below 6 months of age with severe hepatic or renal disease, or with premature infants below 4 weeks, or those with a post-conceptional age of less than 30 weeks.
Use in elderly patients: Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection and it may be useful to monitor renal function.
Acute Overdose
Clinical consequences of overdose have not been reported and acute symptoms of toxicity are unlikely in patients with a normal renal function. Treatment is symptomatic. There is no antidote for this contrast medium. In patients with delayed elimination due to renal insufficiency and in patients who have received excessive doses, the contrast medium can be eliminated by haemodialysis.
Storage Condition
Store at temperatures not exceeding 25° C. Protect from light.
Innovators Monograph
You find simplified version here meriscan
meriscan contains Gadodiamide see full prescribing information from innovator meriscan Monograph, meriscan MSDS, meriscan FDA label