Metaraminol

Metaraminol Uses, Dosage, Side Effects, Food Interaction and all others data.

An adrenergic agonist that acts predominantly at alpha adrenergic receptors and also stimulates the release of norepinephrine. It has been used primarily as a vasoconstrictor in the treatment of hypotension.

Metaraminol is a potent sympathomimetic amine that increases both systolic and diastolic blood pressure. Metaraminol is indicated for prevention and treatment of the acute hypotensive state occurring with spinal anesthesia. It is also indicated as adjunctive treatment of hypotension due to hemorrhage, reactions to medications, surgical complications, and shock associated with brain damage due to trauma or tumor. Metaraminol acts on both α1-adrenergic receptors but appears to have no effect on β-adrenergic receptors. It acts by increasing the force of the heart's pumping action as well as constricting peripheral blood vessels.

Trade Name Metaraminol
Availability Discontinued
Generic Metaraminol
Metaraminol Other Names 1-Metaraminol, Hydroxynorephedrine, L-Metaraminol, m-Hydroxy norephedrine, m-Hydroxyphenylpropanolamine, m-Hydroxypropadrine, Metaraminol, Métaraminol, Metaraminolum
Type Injection
Formula C9H13NO2
Weight Average: 167.205
Monoisotopic: 167.094628665
Protein binding

Approximately 45%

Groups Approved, Investigational
Therapeutic Class
Manufacturer Aguettant Ltd
Available Country United Kingdom
Last Updated: September 19, 2023 at 7:00 am
Metaraminol
Metaraminol

Uses

For the treatment and prevention of hypotension due to hemorrhage, spinal anesthesia, and shock associated with brain damage

How Metaraminol works

Metaraminol acts through peripheral vasoconstriction by acting as a pure alpha-1 adrenergic receptor agonist, consequently increasing systemic blood pressure (both systolic & diastolic). Its effect is thought to be associated with the inhibition of adenyl cyclase which leads to an inhibition of the production of cAMP. Another effect of Metaraminol is that it releases norepinephrine from its storage sites indirectly.

Toxicity

LD50=240 mg/kg (rat, oral); LD50=99 mg/kg (mouse, oral)

Metaraminol Disease Interaction

Major: dehydrationModerate: acidosis

Elimination Route

The effect starts 1-2 min after IV injection, 10 min after IM injection, 5-20 min after subcutaneous injection.

Innovators Monograph

You find simplified version here Metaraminol

http://classyfire.wishartlab.com/tax_nodes/C0000000
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http://classyfire.wishartlab.com/tax_nodes/C0004647
http://classyfire.wishartlab.com/tax_nodes/C0004646
http://classyfire.wishartlab.com/tax_nodes/C0001661
http://classyfire.wishartlab.com/tax_nodes/C0001897
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0000469
http://classyfire.wishartlab.com/tax_nodes/C0004150
http://classyfire.wishartlab.com/tax_nodes/C0003073
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:6794
http://www.hmdb.ca/metabolites/HMDB0014748
http://www.genome.jp/dbget-bin/www_bget?cpd:C07146
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5906
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505593
https://www.chemspider.com/Chemical-Structure.5695.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50239972
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=6805
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=6794
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1201319
https://zinc.docking.org/substances/ZINC000000001695
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000225
http://www.pharmgkb.org/drug/PA164748761
http://www.rxlist.com/cgi/generic2/metar.htm
https://en.wikipedia.org/wiki/Metaraminol
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