Metenkefalin
Metenkefalin Uses, Dosage, Side Effects, Food Interaction and all others data.
Metenkefalin is an endogenous opioid and beta-endorphin. It has been shown to reduce chromosomal abberations in patients with multiple sclerosis. Metenkefalin, along with tridecactide, are under investigation as an immunomodulatory therapy for moderate to severe COVID-19.
Trade Name | Metenkefalin |
Generic | Metenkefalin |
Metenkefalin Other Names | Metenkefalin |
Type | |
Formula | C27H35N5O7S |
Weight | Average: 573.67 Monoisotopic: 573.225719661 |
Groups | Investigational |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Metenkefalin is an investigational endogenous opioid being studied for the treatment of COVID-19.
Metenkefalin is indicated in Bosnia for the treatment of relapsing-remitting multiple sclerosis.
How Metenkefalin works
Metenkefalin is an agonist of µ and δ opioid receptors. It also causes immunostimulation at low doses and immunosuppression at higher doses. Metenkefalin can also inhibit the production of aldosterone, deoxycorticosterone, and corticosterone. Unfortuneately, the mechanisms by which these effects occur have not been well described in the literature.
Toxicity
Data regarding overdoses of metenkefalin are not readily available. Animal overdose studies have not determined an LD50.
Food Interaction
No interactions found.Elimination Route
Metenkefalin reaches a Cmax of 1266.14pg/mL, with a Tmax of 0.16h, and an AUC of 360.64pg*h/mL.
Half Life
The half life of metenkefalin is 4.2-39 minutes.
Innovators Monograph
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