Methazolamide

Methazolamide Uses, Dosage, Side Effects, Food Interaction and all others data.

A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.

Methazolamide is topical carbonic anhydrase inhibitor. Methazolamide is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers. Methazolamide is a sulfonamide derivative; however, it does not have any clinically significant antimicrobial properties. Although methazolamide achieves a high concentration in the cerebrospinal fluid, it is not-considered an effective anticonvulsant. Methazolamide has a weak and transient diuretic effect, therefore use results in an increase in urinary volume, with excretion of sodium, potassium and chloride.

Trade Name Methazolamide
Availability Prescription only
Generic Methazolamide
Methazolamide Other Names Metazolamida, Methazolamid, Méthazolamide, Methazolamide, Methazolamidum, Methenamide, Neptazaneat
Related Drugs acetazolamide, nadolol, pilocarpine ophthalmic, Diamox, Combigan, mitomycin ophthalmic
Weight 25mg, 50mg
Type Oral tablet
Formula C5H8N4O3S2
Weight Average: 236.26
Monoisotopic: 236.003782482
Protein binding

55%

Groups Approved
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Methazolamide
Methazolamide

Uses

Methazolamide is a carbonic anhydrase inhibitor used to treat open angle glaucoma and acute angle closure glaucoma.

For treatment of chronic open-angle glaucoma and acute angle-closure glaucoma

Methazolamide is also used to associated treatment for these conditions: Open-angle Glaucoma (OAG), Acute Angle closure glaucoma

How Methazolamide works

Methazolamide is a potent inhibitor of carbonic anhydrase. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport.

Toxicity

Electrolyte imbalance, development of an acidotic state, and central nervous system effects might be expected to occur in the case of an overdose.

Food Interaction

  • Drink plenty of fluids.
  • Take with food.

Volume of Distribution

  • 17 to 23 L

Elimination Route

Methazolamide is well absorbed from the gastrointestinal tract.

Half Life

14 hours

Innovators Monograph

You find simplified version here Methazolamide

*** Taking medicines without doctor's advice can cause long-term problems.
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