Methenamine And Sodium Salicylate
Methenamine And Sodium Salicylate Uses, Dosage, Side Effects, Food Interaction and all others data.
Methenamine is a heterocyclic organic compound with a cage-like structure similar to adamantane. In salt form it is used for the treatment of urinary tract infection (Example: methenamine hippurate which is the hippuric acid salt of methenamine).
Ingestion of a 1-gram dose of methenamine hippurate produces antibacterial activity in the urine within 1/2 hour. Administration of 1 g twice daily produces continuous antibacterial activity in the urine.
| Trade Name | Methenamine And Sodium Salicylate |
| Generic | Methenamine + sodium salicylate |
| Weight | 162mg + 162.5mg |
| Type | Oral tablet |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Methenamine is a urinary tract antiseptic and antibacterial drug used for the prophylaxis and treatment of frequently recurring urinary tract infections requiring a long-term therapy.
For prophylactic or suppressive treatment of frequently recurring urinary tract infections when long-term therapy is considered necessary. This drug is not used to treat infection and should only be used after appropriate eradication of infection with antimicrobial agents.
Methenamine And Sodium Salicylate is also used to associated treatment for these conditions: Urinary Tract Infection
How Methenamine And Sodium Salicylate works
Methenamine does not have antibacterial properties in an alkaline environment (pH≥6); however, in a more acidic environment (pH<6), methenamine is hydrolyzed to formaldehyde. (1) Formaldehyde is considered to be highly bactericidal. (1) Formaldehyde has nonspecific antibacterial activity and works by denaturing proteins and nucleic acid of bacteria. (1) Certain bacteria such as Proteus sp. can alkalize urine, inhibiting the beneficial activity of formaldehyde. (1) The key role of the salt component of the drug, for example hippuric acid, is to maintain the acidic state of the urine. (1)
Toxicity
Less than 3.5% of patients treated with this drug will experience minor adverse events such as upset stomach, dysuria, nausea, and rash.
Elimination Route
After oral administration, rapid absorption of methenamine occurs. (1)
Half Life
Elimination half-life = 3-4 hours assuming normal renal function. (1)
Clearance
70-90% of a single oral dose of methenamine is excreted unchanged in the urine within 24 hours. (1)
Elimination Route
Methenamine is primarily eliminated via the kidneys. (1)
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