Methixen
Methixen Uses, Dosage, Side Effects, Food Interaction and all others data.
Methixen (or methixene) is a anticholinergic used as an antiparkinsonian agent.
Methixen is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Methixen has been discontinued.
| Trade Name | Methixen |
| Generic | Metixene |
| Metixene Other Names | Methixen, Methixene, Metisene, Metixene, Métixène, Metixeno, Metixenum |
| Type | |
| Formula | C20H23NS |
| Weight | Average: 309.468 Monoisotopic: 309.155120431 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Used for the symptomatic treatment of parkinsonism.
How Methixen works
Parkinsonism is thought to result from an imbalance between the excitatory (cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum. The mechanism of action of centrally active anticholinergic drugs such as metixene is considered to relate to competitive antagonism of acetylcholine at muscarinic receptors in the corpus striatum, which then restores the balance.
Toxicity
Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Elimination Route
Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.
Innovators Monograph
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