Methyl Benzoylecgonine
Methyl Benzoylecgonine Uses, Dosage, Side Effects, Food Interaction and all others data.
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Methyl Benzoylecgonine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
Methyl Benzoylecgonine is a local anesthetic indicated for the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities.
| Trade Name | Methyl Benzoylecgonine |
| Generic | Cocaine |
| Cocaine Other Names | Benzoylmethylecgonine, beta-Cocain, Cocain, Cocaina, Cocaine, Cocainum, Kokain, L-Cocain, L-Cocaine, Methyl benzoylecgonine, Neurocaine |
| Type | |
| Formula | C17H21NO4 |
| Weight | Average: 303.3529 Monoisotopic: 303.147058165 |
| Groups | Approved, Illicit |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Methyl Benzoylecgonine is an ester local anesthetic used during diagnostic procedures and surgeries in or through the nasal cavities.
For the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities.
How Methyl Benzoylecgonine works
Methyl Benzoylecgonine produces anesthesia by inhibiting excitation of nerve endings or by blocking conduction in peripheral nerves. This is achieved by reversibly binding to and inactivating sodium channels. Sodium influx through these channels is necessary for the depolarization of nerve cell membranes and subsequent propagation of impulses along the course of the nerve. Methyl Benzoylecgonine is the only local anesthetic with vasoconstrictive properties. This is a result of its blockade of norepinephrine reuptake in the autonomic nervous system. Methyl Benzoylecgonine binds differentially to the dopamine, serotonin, and norepinephrine transport proteins and directly prevents the re-uptake of dopamine, serotonin, and norepinephrine into pre-synaptic neurons. Its effect on dopamine levels is most responsible for the addictive property of cocaine.
Toxicity
Intense agitation, convulsions, hypertension, rhythm disturbance, coronary insufficiency, hyperthermia, rhabdomyolysis, and renal impairment. Oral mouse LD50 = 96 mg/kg
Food Interaction
No interactions found.Elimination Route
Methyl Benzoylecgonine is absorbed from all sites of application, including mucous membranes and gastrointestinal mucosa. By oral or intra-nasal route, 60 to 80% of cocaine is absorbed.
Half Life
1 hour
Innovators Monograph
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