Methylscopolamine Bromide
Methylscopolamine Bromide Uses, Dosage, Side Effects, Food Interaction and all others data.
A muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors.
Methscopolamine is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine and acts by blocking the muscarinic acetylcholine receptors and is thus classified as an anticholinergic. Methscopolamine has many uses including the prevention of motion sickness. It is not clear how Methscopolamine prevents nausea and vomiting due to motion sickness. The vestibular part of the ear is very important for balance. When a person becomes disoriented due to motion, the vestibule sends a signal through nerves to the vomiting center in the brain, and vomiting occurs. Acetylcholine is a chemical that nerves use to transmit messages to each other. It is believe that Methscopolamine prevents communication between the nerves of the vestibule and the vomiting center in the brain by blocking the action of acetylcholine. Methscopolamine also may work directly on the vomiting center. Methscopolamine must be taken before the onset of motion sickness to be effective.
| Trade Name | Methylscopolamine Bromide |
| Generic | Methscopolamine bromide |
| Methscopolamine bromide Other Names | Hyoscine methobromide, Hyoscine methyl bromide, Methscopolamine bromide, Methylscopolamine bromide, N-methylhyoscine bromide, N-methylscopolammonium bromide, Scopolamine methobromide, Scopolamine methyl bromide |
| Type | |
| Formula | C18H24BrNO4 |
| Weight | Average: 398.297 Monoisotopic: 397.088871 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Methylscopolamine Bromide is a muscarinic antagonist used to treat peptic ulcers, nausea, vomiting, and motion sickness.
Used as adjunctive therapy for the treatment of peptic ulcer. Also used to treat nausea and vomiting due to motion sickness.
Methylscopolamine Bromide is also used to associated treatment for these conditions: Peptic Ulcer
How Methylscopolamine Bromide works
Methscopolamine acts by interfering with the transmission of nerve impulses by acetylcholine in the parasympathetic nervous system (specifically the vomiting center). It does so by acting as a muscarinic antagonist.
Toxicity
Symptoms of a methscopolamine overdose include headache, nausea, vomiting, dry mouth, difficulty swallowing, blurred vision, dilated pupils, hot, dry skin, dizziness; drowsiness, confusion, anxiety, seizures, weak pulse, and an irregular heartbeat. In addition, a curare-like action may occur, i.e., neuromuscular blockade leading to muscular weakness and possible paralysis.
Food Interaction
- Take before a meal. Take methscopolamine bromide 30 minutes before meals and at bedtime for optimal therapeutic effect.
Elimination Route
Poorly and unreliably absorbed, total absorption is 10-25%.
Innovators Monograph
You find simplified version here Methylscopolamine Bromide
