Metiprilone
Metiprilone Uses, Dosage, Side Effects, Food Interaction and all others data.
Metiprilone is a sedative of the piperidinedione derivative family that was previously used for the treatment of insomnia. However, with the introduction of newer drugs with fewer side effects, such as benzodiazepines, the clinical use of methyprylon is now limited. Metiprilone was withdrawn from the U.S. market in June 1965 and the Canadian market in September 1990 due to adverse events.
Metiprilone, a piperidinedione CNS depressant, is close to barbituric acid in structure, but different enough to be called a "non-barbiturate" sedative-hynotic. Metiprilone is used for insomnia and daytime tension. Metiprilone depresses the activity of muscle tissues, the heart, and the respiratory system.
| Trade Name | Metiprilone |
| Generic | Methyprylon |
| Methyprylon Other Names | Methyprylon, Methyprylone, Methyprylonum, Metiprilon, Metiprilona, Metiprilone |
| Type | |
| Formula | C10H17NO2 |
| Weight | Average: 183.2475 Monoisotopic: 183.125928793 |
| Protein binding | 60% |
| Groups | Approved, Illicit, Withdrawn |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the treatment of insomnia.
How Metiprilone works
Metiprilone binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Toxicity
Symptoms of overdose include excitation and convulsions.
Food Interaction
- Take with or without food. The absorption is unaffected by food.
Half Life
6-16 hours
Innovators Monograph
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