Metovine

Metovine Uses, Dosage, Side Effects, Food Interaction and all others data.

Metovine (as Metovine furoate) is an anti-protozoal drug used in the treatment of Entamoeba histolytica and some other protozoal infections. Although it is not currently approved for use in the United States, it was approved by a CDC study in the treatment of 4,371 cases of Entamoeba histolytica from 1977 to 1990.

Metovine is a luminal amebicide, however the mechanism of action of diloxanide is unknown. Metovine destroys the trophozoites of E. histolytica that eventually form into cysts. The cysts are then excreted by persons infected with asymptomatic amebiasis. Metovine furoate is a prodrug, and is hydrolyzed in the gastrointestinal tract to produce diloxanide, the active ingredient.

Trade Name Metovine
Generic Diloxanide
Diloxanide Other Names Diloxanide
Type Tablet
Formula C9H9Cl2NO2
Weight Average: 234.08
Monoisotopic: 233.0010339
Groups Experimental
Therapeutic Class
Manufacturer Venus Pharma
Available Country Pakistan
Last Updated: September 19, 2023 at 7:00 am
Metovine
Metovine

Uses

Metovine is used alone as a primary agent in the treatment of asymptomatic (cyst passers) intestinal amebiasis caused by Entamoeba histolytica. Metovine may also be used concurrently, or sequentially, with other agents such as the nitroimidazoles (eg. metronidazole) in the treatment of invasive or extraintestinal forms of amebiasis.

How Metovine works

Unknown. Metovine may inhibit protein synthesis.

Elimination Route

Bioavailability is 90% (in diloxanide parental form), however diloxanide furoate is slowly absorbed from the gastrointestinal tract.

Half Life

3 hours

Elimination Route

Renal (90%, rapidly excreted as glucuronide metabolite). 10% is excreted in the feces as diloxanide.

Innovators Monograph

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*** Taking medicines without doctor's advice can cause long-term problems.
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