Metricure

Metricure Uses, Dosage, Side Effects, Food Interaction and all others data.

Metricure (INN, also spelled cephapirin), commonly marketed under the trade name Cefadyl, is a first-generation cephalosporin antibiotic that is available in injectable formulations. Production for use in humans has been discontinued in the United States. Metricure is partly plasma-bound and is effective against gram-negative and gram-positive organisms.

Cephapirin is a first-generation cephalosporin that has a wide spectrum of activity against gram-positive and gram-negative organisms. Cephapirin is more resistant to beta-lactamases than are the penicillins and so is effective against staphylococci, with the exception of methicillin-resistant staphylococci.

Table Of contents

• Metricure
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Metricure
Generic	Cefapirin
Cefapirin Other Names	Cefapirin, Cefapirina, Cefapirine, Cefapirinum, Cefaprin, Cephapirin, Cephapirine
Type
Formula	C17H17N3O6S2
Weight	Average: 423.463 Monoisotopic: 423.055876671
Groups	Approved, Vet approved
Therapeutic Class
Manufacturer
Available Country	Australia, Belgium, France, Germany, Ireland, Italy, Netherlands, New Zealand, Poland, Switzerland, United Kingdom
Last Updated:	September 19, 2023 at 7:00 am

Uses

Metricure is a first generation cephalosporin indicated in the treatment of susceptible bacterial infections.

For treatment of infections caused by susceptible bacteria.

Metricure is also used to associated treatment for these conditions: Bronchitis, Pharyngitis, Respiratory Tract Infections (RTI), Skin and Soft Tissue Infections, Tonsillitis, Urinary Tract Infection

How Metricure works

The bactericidal activity of cephapirin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).

Toxicity

Rats exposed via the oral route to cephapirin displayed low acute toxicity (LD₅₀ = 14000 mg/kg). The most common adverse reactions are hypersensitivity reactions and alterations to liver function. Evidence of white blood cell disorders and anaemia were noted in some subjects.

Innovators Monograph

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