Micolette Micro-enema
Micolette Micro-enema Uses, Dosage, Side Effects, Food Interaction and all others data.
Glycerol is a simple polyol compound. It is a colorless, odorless, viscous liquid that is sweet-tasting and non-toxic. Glycerol is used in medical, pharmaceutical and personal care preparations, mainly as a means of improving smoothness, providing lubrication, and as humectants.
Sodium citrate is the sodium salt of citric acid. It is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water,practically insoluble in alcohol. Like citric acid, it has a sour taste.From the medical point of view, it is used as alkalinizing agent. It works by neutralizing excess acid in the blood and urine. It has been indicated for the treatment of metabolic acidosis.
Citrate prevents activation of the clotting cascade by chelating calcium ions. Citrate neutralizes acid in the stomach and urine, raising the pH .
Sodium lauryl sulfoacetate is a wetting agent and surfactant used in enema-type laxative products.
Sodium lauryl sulfoacetate acts as a wetting agent and surfactant in pharmaceutical preparations . It is currently used in enema-type laxatives.
Trade Name | Micolette Micro-enema |
Generic | sodium lauryl sulfoacetate + glycerol + sodium citrate |
Type | |
Therapeutic Class | |
Manufacturer | Pinewood Healthcare |
Available Country | United Kingdom |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Glycerol helps lubricating in sexual intercourse specially for post menopausal women to reduce irritation, for lubrication during vaginal examinations, endoscopy, catheterization for gloves and instruments. It is also used to treat or prevent dry skin.
Sodium citrate is an ingredient used for the anticoagulation of whole blood as part of automated apheresis procedures.
Used as an anticoagulant during plasmophoresis as well as a neutralizing agent in the treatment of upset stomach and acidic urine .
Sodium lauryl sulfoacetate is a laxative indicated in the treatment of constipation and bowel preparation for rectal endoscopy.
Sodium lauryl sulfoacetate is not an active pharmacological ingredient in pharmaceutical preparations and so has no official indication.
Micolette Micro-enema is also used to associated treatment for these conditions: Acidosis, Allergic cough, Allergies, Asthma, Asthma Chronic, Cough, Common Cold, Cough, Coughing caused by Bronchitis, Dehydration, Gouty Arthritis, Heartburn, Metabolic Acidosis, Phlegm, Airway secretion clearance therapy, Oral rehydration therapy, Plasmapheresis, Urine alkalinization therapy, Fluid and electrolyte maintenance therapy, Irrigation during surgical procedures, Irrigation of the ocular surface therapyConstipation, Preparation for rectoscopic or sigmoidoscopic examination
How Micolette Micro-enema works
Citrate chelates free calcium ions preventing them from forming a complex with tissue factor and coagulation factor VIIa to promote the activation of coagulation factor X . This inhibits the extrinsic initiation of the coagulation cascade. Citrate may also exert an anticoagulant effect via a so far unknown mechanism as restoration of calcium concentration does not fully reverse the effect of citrate . Citrate is a weak base and so reacts with hydrochloric acid in the stomach to raise the pH. It it further metabolized to bicarbonate which then acts as a systemic alkalizing agent, raising the pH of the blood and urine . It also acts as a diuretic and increases the urinary excretion of calcium.
Dosage
Micolette Micro-enema dosage
Apply as needed.
Toxicity
Overdose toxicity is mainly due to alkalosis as well as tetany or depressed heart function due to lack of free calcium .
Precaution
Glycerol is for external use only. When using this product do not get into eyes. Do not use on deep or puncture wounds, animal bites & serious burns.
Volume of Distribution
19-39L .
Elimination Route
Tmax of 98-130min .
Half Life
18-54 min
Clearance
Total clearance of 313-1107mL/min .
Elimination Route
Largely eliminated through hepatic metabolism with very little cleared by the kidneys .
Contraindication
Usually well tolerated. People with prior history of sensitivity or allergic reaction to this product or any of its ingredients should not use it.
Storage Condition
Store in a cool & dry place, protected from light. Keep out of reach of children.
Innovators Monograph
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