Midoxil Kid Dt
Midoxil Kid Dt Uses, Dosage, Side Effects, Food Interaction and all others data.
Midoxil Kid Dt Monohydrate (Midoxil Kid Dt Monohydrate) is an acid-stable semi-synthetic oral antibiotic in the cephalosporin family of drugs. Midoxil Kid Dt acts by preventing bacteria from forming protective cell wall necessary for survival. It has superior pharmacokinetic profile over all first generation cephalosporins.
Midoxil Kid Dt, a first-generation cephalosporin antibiotic, is used to treat urinary tract infections, skin and skin structure infections, pharyngitis, and tonsillitis.
| Trade Name | Midoxil Kid Dt |
| Availability | Prescription only |
| Generic | Cefadroxil |
| Cefadroxil Other Names | Cefadroxil, Cefadroxilo, Cefadroxilum, Cephadroxil, D-Cefadroxil |
| Related Drugs | amoxicillin, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, ceftriaxone, levofloxacin, Augmentin |
| Type | Tablet |
| Formula | C16H17N3O5S |
| Weight | Average: 363.388 Monoisotopic: 363.088891359 |
| Protein binding | Binding rates of cefadroxil were 28.1% by U.F. method |
| Groups | Approved, Vet approved, Withdrawn |
| Therapeutic Class | First generation Cephalosporins |
| Manufacturer | Morepen Laboratories |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Midoxil Kid Dt Monohydrate (Midoxil Kid Dt Monohydrate) is used for the treatment of patients with infection caused by susceptible strains of the designated organisms in the following diseases:
*Upper respiratory tract infections caused by Streptococcus pyogenes (Group A beta-hemolytic Streptococci) and Streptococcus pneumoniae.
* Urinary tract infections caused by E. coli, Proteus mirabilis, and Klebsiella species.
* Skin and soft tissue infections caused by Staphylococci (including penicillinase producing strains) and Streptococci.
Midoxil Kid Dt is also used to associated treatment for these conditions: Bacterial Infections, Infection and inflammatory reaction due to internal prosthetic device, implant, and graft, Skin and Subcutaneous Tissue Bacterial Infections, Streptococcal Pharyngitis, Streptococcal tonsillitis, Urinary Tract Infection
How Midoxil Kid Dt works
Like all beta-lactam antibiotics, cefadroxil binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefadroxil interferes with an autolysin inhibitor.
Dosage
Midoxil Kid Dt dosage
The bioavailability and consequent chemotherapeutic effects of Midoxil Kid Dt are unaffected by foods. It may, therefore, be taken with meals or on an empty stomach. Administration with food may be helpful in diminishing potential gastrointestinal complaints occasionally associated with oral cephalosporin therapy.IndicationAdult (dose)Children (Dose)
Upper respiratory tract Infections
1 gm per day in single (q.d.) or divided doses (b.i.d.) for 10 days 12 hourly
30 mg/kg/day in a single or in equally divided doses every 12 hours
Urinary Tract Infections
1 or 2 gm per day in single (q.d.) or divided doses (b.i.d.)
30 mg/kg/day in equally divided doses every 12 hours
For all other UTIs
2 gm per day in divided doses (b.i.d)
30 mg/kg/day in equally divided doses every 12 hours
Skin & soft tissue Infections
1 gm per day in single (q.d.) or divided doses (b.i.d.)
30 mg/kg/day in equally divided doses every 12 hours
Prophylaxis against bacterial endocarditis
2 gm 1 hour prior to the procedure
50 mg/kg 1 hour prior to the procedure
Direction for Reconstitution of suspension
For 100 ml suspension and 100 ml DS suspension: Add 65 ml (13 measuring spoonful) of boiled and cooled water to the dry mixture in the bottle. For ease of preparation add water to the bottle in two portions. Shake well after each addition until all the powder is in suspension.
For 60 ml suspension: Add 40 ml (8 measuring spoonful) of boiled and cooled water to the dry mixture in the bottle. For ease of preparation add water to the bottle in two portions. Shake well after each addition until all the powder is in suspension.
Paediatric Drops: Add 10 ml (2 measuring spoonful) to the bottle and shake vigorously.
Note: Shake both oral suspension and paediatric drops well before each use. Keep the bottle tightly closed. The reconstituted suspension should be stored in a cool and dry place, preferably in refrigerator and unused portion should be discarded after 14 days.
Side Effects
Generally cefadroxil is well tolerated. However, the most commonly reported side effects are gastrointestinal disturbances and hypersensitivity phenomena. Side effects including nausea, vomiting, diarrhoea, dyspepsia, abdominal discomfort, fever, dizziness, headache, arthralgia may also occur.
Toxicity
Nausea, vomiting, diarrhoea, allergic rashes may occur
Precaution
History of hypersensitivity to penicillins or any other β-lactam drugs. History of GI disease (particularly colitis), severe allergies or asthma. Renal impairment. Pregnancy and lactation.
Interaction
There is no known clinically important drug interactions with Midoxil Kid Dt.
Food Interaction
- Take with or without food. Administration with food may be helpful in diminishing potential gastrointestinal complaints occasionally associated with oral cephalosporin therapy.
Midoxil Kid Dt Drug Interaction
Unknown: diphenhydramine, diphenhydramine, atorvastatin, atorvastatin, polyethylene glycol 3350, polyethylene glycol 3350, acetaminophen, acetaminophen, levothyroxine, levothyroxine, acetaminophen, acetaminophen, cyanocobalamin, cyanocobalamin, ascorbic acid, ascorbic acid, cholecalciferol, cholecalciferol, sertraline, sertraline
Midoxil Kid Dt Disease Interaction
Major: colitisModerate: renal dysfunction, dialysis, seizure disorders
Elimination Route
Midoxil Kid Dt is well absorbed on oral administration; food does not interfere with its absorption.
Half Life
1.5 hours
Elimination Route
Over 90% of the drug is excreted unchanged in the urine within 24 hours. Midoxil Kid Dt was detected in the placenta and breast milk.
Pregnancy & Breastfeeding use
Midoxil Kid Dt (Midoxil Kid Dt Monohydrate) is widely used as a first-line oral antibiotic for the treatment of uncomplicated urinary tract infections in pregnant women.
Contraindication
Midoxil Kid Dt is contraindicated in patients with a history of hypersensitivity to any of the ingredients.
Acute Overdose
If amounts >250 mg/kg is ingested, gastric lavage or simulation of vomiting is appropriate.
Storage Condition
Store between 20-25°C. Reconstituted powder for suspension: Store between 2-8°C.
Innovators Monograph
You find simplified version here Midoxil Kid Dt
Midoxil Kid Dt contains Cefadroxil see full prescribing information from innovator Midoxil Kid Dt Monograph, Midoxil Kid Dt MSDS, Midoxil Kid Dt FDA label
FAQ
What is Midoxil Kid Dt used for?
Midoxil Kid Dt is used to treat certain infections caused by bacteria such as infections of the skin, throat, tonsils, and urinary tract. Midoxil Kid Dt is used to treat bacterial infections in many different parts of the body. Midoxil Kid Dt is a broad-spectrum antibiotic of the cephalosporin type, effective in Gram-positive and Gram-negative bacterial infections.
How safe is Midoxil Kid Dt?
Midoxil Kid Dt may rarely cause a severe intestinal condition due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped.
How does Midoxil Kid Dt work?
Midoxil Kid Dt works by killing bacteria.
What are the common side effects of Midoxil Kid Dt?
Common side effects of Midoxil Kid Dt are include:
- indigestion.
- nausea.
- vomiting.
- diarrhea.
- intense abdominal pain.
Is Midoxil Kid Dt safe during pregnancy ?
Animal reproductive studies have not indicated a risk of impaired fertility or harm to the fetus. There are no adequate, controlled studies during human pregnancy.
Is Midoxil Kid Dt safe during breastfeeding?
Midoxil Kid Dt is acceptable in nursing mothers.
Can I drink alcohol with Midoxil Kid Dt?
Avoid alcohol while you take Midoxil Kid Dt may be a good idea. Alcohol may decrease your body's ability to fight your UTI. It's important to talk to your doctor, who knows your medical history.
Can I take Midoxil Kid Dt on an empty stomach?
You may take Midoxil Kid Dt with or without food. Take with food if Midoxil Kid Dt upsets your stomach.
When should be taken of Midoxil Kid Dt?
Midoxil Kid Dt is usually taken with or without food every 12 or 24 hours . Take Midoxil Kid Dt at around the same times every day.
How long does Midoxil Kid Dt take to work?
Peak concentrations of Midoxil Kid Dt are reached one hour after dosing; however, it may take up to 48 hours before infection-related symptoms start to abate.
What is the half life of Midoxil Kid Dt ?
Midoxil Kid Dt is eliminated far more slowly than comparable oral cephalosporins so that intervals between doses can be prolonged to 12-24 hours. Roughly 90% of the substance is eliminated in unchanged form through the kidneys within 24 hours.
How long should I take Midoxil Kid Dt?
For throat and tonsil infections, take Midoxil Kid Dt for a total of 10 days. If you have a urinary tract or skin infection, your provider will determine the right amount of time for you to take this antibiotic.
Who should not take Midoxil Kid Dt?
You should not take Midoxil Kid Dt if you are allergic to Midoxil Kid Dt or other cephalosporin antibiotic. Tell your doctor if you have ever had an allergy to any drug (especially penicillin); intestinal problems, such as colitis.
Can Midoxil Kid Dt cause anxiety?
Midoxil Kid Dt can causes anxiety also with other common side effects.
Does Midoxil Kid Dt cause hair loss?
Midoxil Kid Dt and Erythromycin are known to cause hair loss.
What happens if I miss a dose of Midoxil Kid Dt?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What should I avoid while taking Midoxil Kid Dt?
Midoxil Kid Dt can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.
What happen If I just stop taking Midoxil Kid Dt?
If you stop taking Midoxil Kid Dt too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.
What happens if I overdose?
Seek emergency medical attention.
Can Midoxil Kid Dt affects my liver?
Midoxil Kid Dt may cause a life-threatening side effect, such as pancytopenia and acute liver injury.
