Milium
Milium Uses, Dosage, Side Effects, Food Interaction and all others data.
Milium is dopamine receptor (D2) antagonist which selectively inhibits dopamine at the D2 receptor. It acts principally at receptors in the chemoreceptor trigger zone (CTZ) and also at receptors in the stomach.
Milium is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
| Trade Name | Milium |
| Generic | Domperidone |
| Domperidone Other Names | Domperidona, Domperidone, Domperidonum |
| Weight | 5mg/5ml, 10mg |
| Type | Suspension, Tablet |
| Formula | C22H24ClN5O2 |
| Weight | Average: 425.911 Monoisotopic: 425.161852744 |
| Protein binding | 91%-93% |
| Groups | Approved, Investigational, Vet approved |
| Therapeutic Class | Motility Stimulants, Motility stimulants/Dopamine antagonist, Prokinetic drugs |
| Manufacturer | English Pharmaceuticals Industries |
| Available Country | Pakistan |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Stimulation of gut motility in-
- Non-ulcer dyspepsia
- Oesophageal reflux, reflux oesophagitis and gastritis
- Diabetic gastroparesis
- Functional dyspepsia
- Speeding barium transit in follow through radiological studies
Prevention and symptomatic relief of acute nausea and vomiting from any cause including cytotoxic therapy, radiotherapy and antiparkinsonism therapy.
In the prophylactic treatment of migraine.
Milium is also used to associated treatment for these conditions: Diabetic Gastroparesis, Dyspepsia, Erosive Esophagitis, Gastrointestinal Symptoms, Non-erosive Reflux Esophagitis Disease (NERD), Upper gastrointestinal motility disorders
How Milium works
Milium acts as a gastrointestinal emptying (delayed) adjunct and peristaltic stimulant. The gastroprokinetic properties of domperidone are related to its peripheral dopamine receptor blocking properties. Milium facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Antiemetic: The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting
Dosage
Milium dosage
Adults: 10 - 20 mg every 4 - 8 hours daily
Children: 0.2 - 0.4 mg/kg every 4 - 8 hours daily.
Milium tablet and suspension should be taken 15 - 30 minutes before a meal. For acute nausea and vomiting, maximum period of treatment is 12 weeks.
Side Effects
Milium may produce hyperprolactinemia which may cause galactorrhea & breast enlargement, soreness and reduced libido. It may rarely cause dry mouth, thirst, headache, nervousness, drowsiness, diarrhea, skin rash and itching.
Toxicity
Side effects include galactorrhea, gynecomastia, or menstrual irregularities.
Precaution
Milium should be used with absolute caution in case of children because there may be an increased risk of extra-pyramidal reactions in young children because of an incompletely developed blood brain barrier.
Interaction
Milium may reduce the hypoprolactinaemic effect of bromocriptine. Anti-muscarinics and opioid analgesics may antagonize the action of Milium on gastrointestinal function.
Food Interaction
- Take before a meal. Take 15-30 minutes before meals.
Half Life
7 hours
Pregnancy & Breastfeeding use
Use in pregnancy: The safety of this drug has not been established for pregnant women. So it is not recommended during pregnancy.
Use in lactation: Milium may precipitate galactorrhea and improve postnatal lactation, which is secreted in breast milk but in very small quantities insufficient to be considered harmful.
Contraindication
Milium is contraindicated to the patients who have hypersensitivity to this drug and in case of neonates.
Acute Overdose
Overdose has been reported primarily in infants and children. Symptoms of overdosage may include disorientation, somnolence and extrapyramidal reactions. There is no specific antidote to domperidone, but in the event of overdose, the administration of activated charcoal may be useful. Anticholinergics, antiparkinson drugs may be useful in controlling extrapyramidal reactions. The patient should be observed closely and supportive measures employed.
Storage Condition
Store in a cool dry place protected from light. Keep out of reach of children.
Innovators Monograph
You find simplified version here Milium
Milium contains Domperidone see full prescribing information from innovator Milium Monograph, Milium MSDS, Milium FDA label
FAQ
What is Milium used for?
Milium help to stop feeling or being sick like as nausea or vomiting.It can also be used to treat stomach pain if you're having end of life care. Milium is sometimes used to increase milk supply.
Is Milium safe to take?
For most people, taking Milium is safe.If you have heart problems or are taking other medicines, you should first check with your healthcare professional that this medicine is appropriate.
What are the side effects of Milium?
Common side effects of Milium are include:
- swelling of the ankles/feet.
- unusual tiredness.
- mental/mood changes (e.g., nervousness, irritability)
- hot flashes.
- breast swelling/pain.
- unusual leakage of milk from the breast.
- changes in menstrual periods.
- decreased sexual ability.
Is Miliumsafe during pregnancy?
Milium is not usually recommended in pregnancy.
Why Milium is not safe in pregnancy?
Milium is contraindicated for use in pregnant women and in women suspected of being pregnant, due to teratogenicity observed in reproductive toxicity studies.
Is Milium safe during breastfeeding?
A very small amount of the Milium you take can pass into your breast milk, but there is no record of harmful side effects in the baby from the mother taking Milium.
Can I drink alcohol with Milium?
It is best to avoid alcohol when taking Milium. Drinking alcohol can make side effects worse, such as sleepiness or an irregular heartbeat.
How long does Milium take to work?
Milium often takes at least three or four days before you notice any effect. It usually takes about two weeks to get a maximum effect, but some find it takes even longer.
Can I take Milium before bed?
Milium is best taken 15 to 30 minutes before meals and id necessary at bedtime.
Is Milium good for acid reflux?
It decreases postprandial reflux time and is therefore used to treat regurgitation and vomiting.
Can I take Milium after eating?
Milium is best taken about 15 to 30 minutes before meals, with a glass of water. If you take Milium after a meal, it will still work, but it may take longer to have an effect.
Is Milium good for gastritis?
Milium has a good advantage in the treatment of reflux gastritis and is more effective than conventional treatment.Milium is a kind of drug to strengthen gastric motility.
What does Milium do to your body?
Milium is a medicine that increases the movements or contractions of the stomach and bowel. Milium is also used to treat nausea and vomiting caused by other drugs used to treat Parkinson's Disease.
Is Milium safe for kidneys?
Milium are not significantly renally cleared and can be used in CKD.
Does Milium help anxiety?
Milium is used to treat severe anxiety like as emotional state where you may sweat, tremble, feel anxious and have a fast heartbeat or agitation.
Does Milium raise blood pressure?
Milium increases blood pressure and heart rate without inducing nocturnal hypertension in apomorphine treated patients with idiopathic Parkinson's disease.
Is Milium a narcotic?
Milium is not a controlled substance e.g. sleeping pills, valium, narcotics.
Does Milium cause depression?
Milium can cause central nervous system side effects such as fatigue, irritability, or depression.
Can I take Milium for a long time?
You should usually take Milium for up to a week.Because Milium can cause an irregular heartbeat if you take it for longer or at a high dose.
What happens when I stop taking Milium?
Most women do not experience discomfort when stopping the medication, gradual weaning from the medication will help the mother's milk supply to adjust without frustrating the baby or causing her discomfort. It is very important to stop the Milium slowly.
