Minirin Melt Sublingual Tablet 60 mcg

Minirin Melt Sublingual Tablet 60 mcg Uses, Dosage, Side Effects, Food Interaction and all others data.

Minirin Melt Sublingual Tablet 60 mcg
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Minirin Melt Sublingual Tablet 60 mcg
Generic	Desmopressin Acetate
Weight	60 mcg
Type	Sublingual Tablet
Therapeutic Class	Synthetic analogue of ADH
Manufacturer	Radiant Pharmaceuticals Ltd.
Available Country	Bangladesh
Last Updated:	October 19, 2023 at 6:27 am

Uses

Minirin Melt Sublingual Tablet 60 mcg film coated tablets are indicated as antidiuretic replacement therapy in the management of central diabetes insipidus and for the management of the temporary polyuria and polydipsia following head trauma or surgery in the pituitary region. Minirin Melt Sublingual Tablet 60 mcg Tablets are ineffective ... Read more

Dosage

Minirin Melt Sublingual Tablet 60 mcg dosage

Sublingual tablet: Treatment of diabetes insipidus: Dosage is individual in diabetes insipidus but the total daily sublingual dose normally lies in the range of 120 micrograms to 720 micrograms. A suitable starting dose in adults and children is 60 micrograms three times daily, administered sublingually. This dosage regimen should then be adjusted in accordance with the patient's response. For the majority of patients, the maintenance dose is 60 micrograms to 120 micrograms sublingually three times daily. Post-hypophysectomy polyuria/polydipsia: The dose of Minirin Melt Sublingual Tablet 60 mcg Melt should be controlled by measurement of urine osmolality. Film coated tablet: Adults and Children: It is recommended that patients be started on doses of 0.05 mg (1/2 of the 0.1 mg tablet) two times a day and individually adjusted to their optimum therapeutic dose. Most patients in clinical trials found that the optimal dosage range is 0.1 mg to 0.8 mg daily, administered in divided doses. Each dose should be separately adjusted for an adequate diurnal rhythm of water turnover. Total daily dosage should be increased or decreased in the range of 0.1 mg to 1.2 mg divided into two or three daily doses as needed to obtain adequate antidiuresis. Geriatric Use: This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.

Side Effects

Infrequently, large doses of the intranasal formulations of Minirin Melt Sublingual Tablet 60 mcg Tablets and Minirin Melt Sublingual Tablet 60 mcg Injection have produced transient headache, nausea, flushing and mild abdominal cramps. These symptoms have disappeared with reduction in dosage.

Precaution

Very rare cases of hyponatremia have been reported from world-wide postmarketing experience in patients treated with Minirin Melt Sublingual Tablet 60 mcg Tablets. Minirin Melt Sublingual Tablet 60 mcg Tablets are a potent antidiuretic which, when administered, may lead to water intoxication and hyponatremia. Unless properly diagnosed and treated hyponatremia can be fatal. Therefore, fluid restriction is recommended and should be discussed with he patient and/or guardian. Careful medical supervision is required.Intranasal formulations of desmopressin acetate at high doses and Minirin Melt Sublingual Tablet 60 mcg Injection have infrequently produced a slight elevation of blood pressure which disappears with a reduction of dosage. Although this effect has not been observed when single oral doses up to 0.6 mg have been administered, the drug should be used with caution in patients with coronary artery insufficiency and/or hypertensive cardiovascular disease, because of a possible rise in blood pressure.

Interaction

Although the pressor activity of desmopressin acetate are very low compared to its antidiuretic activity, large doses of Minirin Melt Sublingual Tablet 60 mcg Tablets should be used with other pressor agents only with careful patient monitoring. The concomitant administration of drugs that may increase the risk of water intoxication with hyponatremia, (e.g. tricyclic antidepressants, selective serotonin re-uptake inqibitors, chlorpromazine, opiate analgesics, NSAIDs, lamotrigine and carbamazepine) should be performed with caution.

Pregnancy & Breastfeeding use

There have been no controlled studies in nursing mothers. Caution should be exercised when desmopressin acetate is administered to nursing mothers.

Contraindication

Minirin Melt Sublingual Tablet 60 mcg Tablets are contraindicated in individuals with known hypersensitivity to desmopressin acetate or to any of the components of Minirin Melt Sublingual Tablet 60 mcg Tablets. Minirin Melt Sublingual Tablet 60 mcg Tablets are contraindicated in patients with moderate to severe renal impairment (defined as a creatinine clearance below 50 mL/min). Minirin Melt Sublingual Tablet 60 mcg Tablets are contraindicated in patients with hyponatremia or a history of hyponatremia.