Mintezol
Mintezol Uses, Dosage, Side Effects, Food Interaction and all others data.
2-Substituted benzimidazole first introduced in 1962. It is active against a variety of nematodes and is the drug of choice for strongyloidiasis. It has CNS side effects and hepatototoxic potential. (From Smith and Reynard, Textbook of Pharmacology, 1992, p919)
Mintezol is a fungicide and parasiticide. Mintezol is also a chelating agent, which means that it is used medicinally to bind metals in cases of metal poisoning, such as lead poisoning, mercury poisoning or antimony poisoning. Mintezol is vermicidal and/or vermifugal against Ascaris lumbricoides ("common roundworm"), Strongyloides stercoralis (threadworm), Necator americanus, Ancylostoma duodenale (hookworm), Trichuris trichiura (whipworm), Ancylostoma braziliense (dog and cat hookworm), Toxocara canis, Toxocara cati (ascarids), and Enterobius vermicularis (pinworm). Mintezol also suppresses egg and/or larval production and may inhibit the subsequent development of those eggs or larvae which are passed in the feces.
| Trade Name | Mintezol |
| Availability | Discontinued |
| Generic | Thiabendazole |
| Thiabendazole Other Names | TBDZ, Thiabendazole, Tiabendazol, Tiabendazole, Tiabendazolum |
| Related Drugs | metronidazole, ivermectin, Flagyl, albendazole, mebendazole, nitazoxanide, piperazine, pyrantel, Albenza, Stromectol |
| Type | Chewable tablets and suspension |
| Formula | C10H7N3S |
| Weight | Average: 201.248 Monoisotopic: 201.036067929 |
| Groups | Approved, Vet approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Mintezol is a benzimidazole used in the treatment of strongyloides, cutaneous larva migrans, visceral larva migrans, and trichinosis infections.
For the treatment of strongyloidiasis (threadworm), cutaneous larva migrans (creeping eruption), visceral larva migrans, and trichinosis.
How Mintezol works
The precise mode of action of thiabendazole on the parasite is unknown, but it most likely inhibits the helminth-specific enzyme fumarate reductase.
Toxicity
Overdosage may be associated with transient disturbances of vision and psychic alterations. The oral LD 50 is 3.6 g/kg, 3.1 g/kg and 3.8 g/kg in the mouse, rat, and rabbit respectively.
Mintezol Drug Interaction
Unknown: amoxicillin / clavulanate, multivitamin with minerals, ciprofloxacin, sulfamethoxazole / trimethoprim, sulfamethoxazole / trimethoprim, glucose, lvp solution, multivitamin, metronidazole, multivitamin with minerals, acetaminophen, penicillin v potassium, tiotropium, ascorbic acid
Mintezol Disease Interaction
Moderate: supportive therapy, liver disease, renal dysfunction
Elimination Route
Rapidly absorbed and peak plasma concentration is reached within 1 to 2 hours after the oral administration of a suspension. Some systemic absorption may occur from topical preparations applied to the skin.
Half Life
The half-life for thiabendazole in both normal and anephric patients is 1.2 hours (range 0.9 to 2 hours). The half-life for the 5-hydroxythiabendazole metabolite in both normal and anephric patients is 1.7 hours (range 1.4 to 2 hours).
Elimination Route
It is metabolized almost completely to the 5-hydroxy form which appears in the urine as glucuronide or sulfate conjugates.
Innovators Monograph
You find simplified version here Mintezol
