Mitomycin-C Tablet 1 mg
Mitomycin-C Tablet 1 mg Uses, Dosage, Side Effects, Food Interaction and all others data.
Trade Name | Mitomycin-C Tablet 1 mg |
Generic | Mitomycin C |
Weight | 1 mg |
Type | Tablet |
Therapeutic Class | Cytotoxic Chemotherapy |
Manufacturer | Kyowa, Japan |
Available Country | Bangladesh |
Last Updated: | October 19, 2023 at 6:27 am |
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Uses
This is indicated in Diabetic foot infections; Chronic lymphatic leukaemia; Chronic myelogenous leukaemia; Gastric, Colorectal, Lung, Pancreatic, Cervix, Endometrium, Breast, Bladder, Head & neck carcinoma.Dosage
Mitomycin-C Tablet 1 mg dosage
Solid tumours Suggested regimen: Initial: 10-20 mg/m2; may repeat 6-8 wkly depending on blood count. Do not repeat if leucocyte and platelet counts are below acceptable levels. Do not re-administer if the nadir of the leucocyte count is <2,000 cells/mm3Intravesical Superficial bladder tumours: Instill 10-40 mg 1 -3 times/wk for a total of 20 dosesPrevention of recurrent bladder tumours: Instill 20 mg 2 wkly or 40 mg 1-3-mthly.Side Effects
Hemolytic uremic syndrome (<15%), Myelosuppression (64%), Nausea/ vomiting (14%), Fever (14%), Stomatitis (4%), Increased serum creatinine (2%), Mucous membrane toxicity (4%) , Fatigue, Pulmonary toxicity, Dyspnea, Cystitis, Interstitial fibrosis, Nephrotoxicity, Amenorrhea, Alopecia, Myelosuppression, haemolytic-uraemic syndrome.Precaution
Repeated haematologic studies are necessary during treatment and for at least 7 wk after discontinuation of the drug. Discontinue use when the leucocyte count decreases to <4000/mm3 or the platelet count decreases to <150,000/mm3 or if a progressive decline in either occurs. Monitor patient for signs of renal or pulmonary toxicity.Interaction
Increased incidence of cardiotoxicity with doxorubicin.Pregnancy & Breastfeeding use
Pregnancy category- DContraindication
Hypersensitivity. Patient with platelet counts <100,000/mm3, leukocyte counts <4,000/mm3 or serum creatinine concentration >1.7 mg/dL. Patient with substantial prolongation of prothrombin time or bleeding time, coagulation disorders, increased bleeding tendency. Pregnancy and lactation.Storage Condition
Powder for injection: Store between 15-30°C. Protect from light. Reconstituted solution: Stable for 1 wk when stored between 15-25°C and 2 wk when stored between 2-8°C.Innovators Monograph
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