Modrenal
Modrenal Uses, Dosage, Side Effects, Food Interaction and all others data.
Modrenal is an inhibitor of 3 beta-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome. It was withdrawn from the United States market in April 1994.
Modrenal blocks an enzyme involved in the production of several steroids including cortisol. Inhibiting this enzyme inhibits the production of cortisol. In Cushing's syndrome, the adrenal gland overproduces steroids. Although steroids are important for various functions of the body, too much can cause problems. Modrenal reduces the amount of steroids produced by the adrenal gland. This product was withdrawn from the U.S. market in April 1994.
| Trade Name | Modrenal |
| Generic | Trilostane |
| Trilostane Other Names | Trilostane, Trilostano, Trilostanum |
| Type | |
| Formula | C20H27NO3 |
| Weight | Average: 329.4333 Monoisotopic: 329.199093735 |
| Groups | Approved, Investigational, Vet approved, Withdrawn |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Used in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible.
How Modrenal works
Modrenal produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5,4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.
Toxicity
Symptoms of overdose include darkening of skin, drowsiness or tiredness, loss of appetite, mental depression, skin rash, and/or vomiting.
Food Interaction
No interactions found.Half Life
8 hours.
Innovators Monograph
You find simplified version here Modrenal
