Molday
Molday Uses, Dosage, Side Effects, Food Interaction and all others data.
Molday is a prodrug which is metabolized to rhein. It is currently approved in France for the treatment of osteoarthritis although the use of diacerein is restricted due to the side effects including severe diarrhea . Molday is under investigation for the treatment of Insulin Resistance, Diabetes Mellitus (Type 2), and Diabetes-Related Complications.
Decreases inflammation and cartilage destruction and also corrects altered osteoblast acitivity .
| Trade Name | Molday |
| Generic | Diacerein |
| Diacerein Other Names | Diacerein, Diacereína |
| Type | Capsule, Sachet |
| Formula | C19H12O8 |
| Weight | Average: 368.297 Monoisotopic: 368.053217346 |
| Protein binding | 99% of rhein is bound to plasma proteins . |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | Intra Life Pvt Ltd |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Molday is an slow-onset anthraquinone IL-1 inhibitor used in the treatment of degenerative joint diseases like osteoarthritis.
For the treatment of osteoarthritis affecting the hip or knee .
Molday is also used to associated treatment for these conditions: Osteoarthritis in the Hip Joint, Osteoarthritis of the Knee
How Molday works
Molday's active metabolite rhein Rhein reduces cartilage destruction by decreasing expression of matrix metalloproteinase (MMP)-1 and -3 as well as upregulating tissue inhibitor of matrix metalloproteinases which serve to reduce the activity of several MMPs . The anti-inflammatory action of rhein reduces the level of interleukin-1beta activity which plays a large role in reduction of extracellular matrix production, MMP activity, and continued inflammation . Rhein reduces abnormal osteoblast synthetic activity through an unknown mechanism .
Toxicity
Rhein Rhein has an oral LD50 of >5000mg/kg in mice. This is equivalent to a diacerein dose of >6476mg/kg.
Volume of Distribution
15-60L .
Elimination Route
Bioavailability of 50-60% . Entirely converted to the active metabolite rhein Rhein before reaching systemic circulation.
Half Life
4-10h .
Clearance
Total CL is 1.5L/h and renal CL is 0.1L/h .
Elimination Route
37% excreted in urine and 53% in feces as estimated in rats .
Innovators Monograph
You find simplified version here Molday
FAQ
What is Molday used for?
Molday is a slow-acting medicine of the class anthraquinone used to treat joint diseases such as osteoarthritis.
How safe is Molday?
Molday is safe, apart from a substantially higher risk of diarrhoea, especially with longer-term use.Molday has an acceptable safety profile, particularly in comparison with that of NSAIDs and paracetamol. The ESCEO positions Molday as a first-line pharmacological background treatment of osteoarthritis.
How does Molday work?
Molday works by blocking the actions of interleukin-1 beta, a protein involved in the inflammation and destruction of cartilage that plays a role in the development of symptoms of degenerative joint diseases such as osteoarthritis.
What are the common side effects of Molday?
Common side effects of Molday are include:
- Diarrhoea.
- Stomach discomfort and pain.
- Nausea.
- Vomiting.
- Yellowing of skin and eyes.
- Urine discoloration.
- Increase in liver enzyme levels.
- Allergic skin reaction.
Is Molday safe during pregnancy?
Molday should not be administered during pregnancy.
Is Molday safe during breastfeeding?
Molday should not be administered during lactation.
Can I drink alcohol with Molday?
Patients should be advised to limit their alcohol intake while on treatment with Molday.
Can I drive after taking Molday?
Molday may cause dizziness and drowsiness. So if you observe such symptoms, then do not drive.
When should be taken of Molday?
The recommended starting dose is 50 mg once daily with evening meal for the first 2 to 4 weeks of treatment, after which the recommended daily dose is 50 mg twice daily.
Can I take Molday on an empty stomach?
The Molday should be taken with food, one with breakfast and the other with evening meal.
How often can I take Molday?
The recommended dose is 50 mg to be taken twice daily.
How long does Molday take to work ?
Molday starts showing its action in 2-3 hours. The duration of action of Molday is 27 hours
How long can Molday be taken?
The duration of action of Molday is 27 hours.
Who should not take Molday?
Molday should not be used in any patient with liver disease or a history of liver disease, and doctors should be monitoring their patients for early signs of liver problems.
Is Molday an antibiotic?
Molday is a novel antibacterial agent; the antibacterial breakpoint could not be found in the literature or in standards.
What happen If I missed a dose of Molday?
If you forget to take a dose of Molday, make sure that you remember to take your next dose when it is due. Do not take two doses together to make up for a missed dose.
What happen if I overdose on Molday?
Never take more than the prescribed dose. Seek emergency medical treatment or contact the doctor if you suspect that you might have taken an overdose of Molday.
Can Molday causes diarrhoea?
Molday may cause diarrhoea or loose stools in the first few days of treatment. Contact your doctor if the diarrhoea does not stop within 3-4 days.
Who should not take Molday?
Avoid taking Molday if you are allergic to it. Seek medical attention if you notice any allergic reactions such as skin rash, hives (painful, itchy eruptions that sting), swelling (face, lips, tongue, etc.), breathing difficulty, etc. Molday is excreted through the kidneys.
If you have pre-existing kidney problems, this medicine may accumulate in your kidneys and further worsen your condition. Hence, this medicine is not recommended for use if you have kidney problems.
Can Molday affects my heart ?
Molday Improves Left Ventricular Remodeling and Cardiac Function by Reducing the Inflammatory Response after Myocardial Infarction.
Does Molday cause kidney damage?
Molday has shown to be safe and effective in patients with moderate to severe renal impairment, and dose adjustment is not required in these patients.
Can Molday affects my liver?
Around 0.5% of patients on Molday had some kind of liver reaction, with most cases being mild, reversible increases in serum transaminases.
