Molindone
Molindone Uses, Dosage, Side Effects, Food Interaction and all others data.
An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of clozapine. (From AMA Drug Evaluations Annual, 1994, p283)
Molindone is a dihydroindolone compound which is not structurally related to the phenothiazines, the butyrophenones, or the thioxanthenes. Molindone has a pharmacological profile in laboratory animals which predominantly resembles that of major tranquilizers causing reduction of spontaneous locomotion and aggressiveness, suppression of a conditioned response and antagonism of the bizarre stereotyped behavior and hyperactivity induced by amphetamines. In addition, molindone antagonizes the depression caused by the tranquilizing agent tetrabenazine.
| Trade Name | Molindone |
| Availability | Discontinued |
| Generic | Molindone |
| Molindone Other Names | (+/-)-molindone, Molindona, Molindone, Molindonum |
| Related Drugs | quetiapine, Abilify, Seroquel, aripiprazole, olanzapine, risperidone, haloperidol, prochlorperazine, Haldol, Compazine |
| Weight | 10mg, 25mg, 5mg |
| Type | Oral tablet |
| Formula | C16H24N2O2 |
| Weight | Average: 276.374 Monoisotopic: 276.183778022 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Molindone is an antipsychotic used to treat schizophrenia.
Molindone is used for the management of the manifestations of psychotic disorders.
Molindone is also used to associated treatment for these conditions: Schizophrenia
How Molindone works
The exact mechanism has not been established, however, based on electroencephalogram (EEG) studies, molindone is thought to act by occupying (antagonizing) dopamine (D2) receptor sites in the reticular limbic systems in the brain, thus decreasing dopamine activity. Decreased dopamine activity results in decreased physiological effects normally induced by excessive dopamine stimulation, such as those typically seen in manifestations of psychotic disorders.
Food Interaction
- Avoid alcohol. Severe CNS depression, which can be caused by alcohol, is a contraindication for molindone hydrochloride therapy.
[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.
Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.
Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
Molindone Drug Interaction
Major: clozapine, clozapineModerate: aripiprazole, aripiprazole, lorazepam, lorazepam, citalopram, citalopram, duloxetine, duloxetine, iloperidone, iloperidone, ziprasidone, ziprasidone, haloperidol, haloperidol, paliperidone, paliperidone, lurasidone, lurasidone
Molindone Disease Interaction
Major: dementia, CNS depression/coma, related psychosis, previous neuroleptic malignant syndrome (NMS), seizure disorders, acute alcohol intoxication, cardiovascular disease, CNS depression, NMS, tardive dyskinesiaModerate: seizure, hyperprolactinemia/breast cancer, intestinal obstruction, neutropenia, anticholinergic effects, dehydration, hyperprolactinemia, liver disease, parkinsonism
Elimination Route
Rapidly absorbed from the gastrointestinal tract following oral administration.
Elimination Route
Human metabolic studies show molindone to be rapidly absorbed and metabolized when given orally. There are 36 recognized metabolites with less than 2-3% unmetabolized molindone being excreted in urine and feces.
Innovators Monograph
You find simplified version here Molindone
