Momento Tablet 5 mg
Momento Tablet 5 mg Uses, Dosage, Side Effects, Food Interaction and all others data.
Momento Tablet 5 mg is a long-acting, tricyclic, non-sedating, selective peripheral histamine H1-receptor antagonist which inhibits the release of pro-inflammatory mediators from human mast cells and basophils.
Momento Tablet 5 mg is a long-acting second-generation H1-receptor antagonist which has a selective and peripheral H1-antagonist action. Histamine is a chemical that causes many of the signs that are part of allergic reactions, such as the swelling of tissues. Histamine is released from histamine-storing cells (mast cells) and attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell to be "activated," releasing other chemicals which produce the effects that we associate with allergies. Momento Tablet 5 mg blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation of cells by histamine. Unlike most other antihistamines, Momento Tablet 5 mg does not enter the brain from the blood and, therefore, does not cause drowsiness.
| Trade Name | Momento Tablet 5 mg |
| Availability | Prescription only |
| Generic | Desloratadine |
| Desloratadine Other Names | Descarboethoxyloratadine, Desloratadina, Desloratadine |
| Related Drugs | prednisone, cetirizine, loratadine, fluticasone nasal, promethazine, diphenhydramine, Zyrtec, Xolair |
| Weight | 5 mg |
| Type | Tablet |
| Formula | C19H19ClN2 |
| Weight | Average: 310.821 Monoisotopic: 310.123676325 |
| Protein binding | Desloratadine is bound approximately 82 to 87% to plasma proteins, while its active metabolite, 3-hydroxydesloratadine, is bound approximately 85 to 89%. |
| Groups | Approved, Investigational |
| Therapeutic Class | Non-sedating antihistamines |
| Manufacturer | Beximco Pharmaceuticals Ltd. |
| Available Country | Bangladesh |
| Last Updated: | October 19, 2023 at 6:27 am |
Uses
Allergic Rhinitis: Momento Tablet 5 mg is used for the relief of the nasal and non-nasal symptoms of allergic rhinitis (Both seasonal and perennial) in patients 2 years of age and older.
Chronic Idiopathic Urticaria: Momento Tablet 5 mg is also used for the symptomatic relief of pruritus, reduction in the number of hives, and size of hives, in patients with chronic idiopathic urticaria 2 years of age and older.
Momento Tablet 5 mg is also used to associated treatment for these conditions: Allergic Rhinitis (AR), Asthma, Chronic Idiopathic Urticaria, Common Cold, Nasal Congestion, Perennial Allergic Rhinitis (PAR), Seasonal Allergic Rhinitis, Nasal symptoms, Non-nasal symptoms, Antihistamine
How Momento Tablet 5 mg works
Like other H1-blockers, Momento Tablet 5 mg competes with free histamine for binding at H1-receptors in the GI tract, uterus, large blood vessels, and bronchial smooth muscle. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms (eg. nasal congestion, watery eyes) brought on by histamine.
Dosage
Momento Tablet 5 mg dosage
Pediatric drops :
- Child 6 -11 months of age: 2 ml drops once daily
- Child 1 -2 years of age: 2.5 ml drops once daily
Syrup:
- Child 6-11 months of age: 2 ml once daily
- Child 1-5 years of age: 2.5 ml once daily
- Child 6-11 years of age: 5 ml once daily
- Adults & > 12 years of age: 10 ml once daily
Tablet:
- Adults and children 12 years of age and over: 5 mg daily
Side Effects
Momento Tablet 5 mg is generally well tolerated. However, dry mouth, fatigue, somnolence and myalgia are commonly reported side-effects. Less common side-effects may include dizziness, headache and nausea. Rarely rash, pruritus and urticaria may occur.
Toxicity
Information regarding desloratadine overdose is limited, although somnolence has been reported. In case of overdose, symptomatic and supportive treatment, including removing the unabsorbed drug, is recommended; note, however, that desloratadine and its active metabolite 3-hydroxydesloratadine cannot be eliminated by hemodialysis.
In animal studies, lethality was observed at or above doses of 250 mg/kg in rats and of 353 mg/kg in mice (oral LD50), doses that represent 120 and 290 times the human exposure based on the recommended daily oral dose. In monkey, no deaths occurred at doses up to 250 mg/kg, representing an exposure roughly 810 times that of the recommended dose in humans.
Precaution
Hepatic and renal impairment. Pregnancy and lactation.
Interaction
Concomitant administration of Erythromycin, Ketoconazole, Azithromycin, Fluoxetine, and Cimetidine with Momento Tablet 5 mg increased the plasma concentration of Momento Tablet 5 mg. But there were no clinically relevant changes in the safety profile of Momento Tablet 5 mg.
Food Interaction
- Take with or without food. The absorption is unaffected by food.
Momento Tablet 5 mg Disease Interaction
Elimination Route
Momento Tablet 5 mg administered orally for ten days to healthy volunteers as a 5 mg tablet once daily resulted in a mean Tmax of approximately 3 hours, a mean steady-state Cmax of 4 ng/ml, and a mean steady-state AUC of 56.9 ng*hr/ml. A similar profile was observed using 10 ml of an oral solution containing 5 mg of desloratadine. Food was found not to affect desloratadine absorption.
Half Life
Momento Tablet 5 mg has a mean plasma elimination half-life of approximately 27 hours.
Elimination Route
Approximately 87% of a C-desloratadine dose was equally recovered in urine and feces as metabolic products.
Pregnancy & Breastfeeding use
Pregnancy: There are no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, Momento Tablet 5 mg should be used in pregnancy only if clearly needed.
Lactation: Momento Tablet 5 mg passes into breast milk. Therefore, a decision should be made whether to discontinue nursing or to discontinue Momento Tablet 5 mg, taking into account the importance of the drug to the mother.
Contraindication
Momento Tablet 5 mg is contraindicated in patient having hypersensitivity to this medication or to any of its ingredients or Loratadine.
Special Warning
Paediatric Use: The safety and effectiveness of Momento Tablet 5 mg in pediatric patients under 2 years of age have not been established.
Geriatric Use: In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
In adult patients with liver or renal impairment: A starting dose of one 5 mg tablet every other day is recommended based on pharmacokinetic data.
Acute Overdose
No clinically relevant adverse events have been reported in case of overdosage. However, in the event of overdosage, symptomatic and supportive treatment is recommended.
Storage Condition
Store in a cool and dry place, protected from light.
Innovators Monograph
You find simplified version here Momento Tablet 5 mg
Momento Tablet 5 mg contains Desloratadine see full prescribing information from innovator Momento Tablet 5 mg Monograph, Momento Tablet 5 mg MSDS, Momento Tablet 5 mg FDA label
FAQ
What is Momento Tablet 5 mg used for?
Momento Tablet 5 mg is an antihistamine used to relieve allergy symptoms such as watery eyes, runny nose, itching eyes/nose, sneezing, hives, and itching. Momento Tablet 5 mg is used to treat allergies. It is an active metabolite of loratadine. It is used to relieve the symptoms of hay fever and hives of the skin.
How safe is Momento Tablet 5 mg?
Momento Tablet 5 mg is a safe and effective treatment for allergic diseases.
How does Momento Tablet 5 mg work?
Momento Tablet 5 mg works by blocking histamine, a substance in the body that causes allergic symptoms.
What are the common side effects of Momento Tablet 5 mg?
Common side effects of Momento Tablet 5 mg are include:
- headache.
- nausea.
- diarrhea.
- dizziness.
- sore throat.
- dry mouth.
- muscle pain.
- extreme tiredness
Is Momento Tablet 5 mg safe during pregnancy?
As such these findings provide reassurance by indicating that the fetal safety of Momento Tablet 5 mg is similar to the currently recommended antihistamines during pregnancy and thus Momento Tablet 5 mg can be considered to be another option for use during pregnancy.
Is Momento Tablet 5 mg safe during breastfeeding?
Considering the minimal exposure of a nursing infant to the drugs through breast milk, maternal use of Momento Tablet 5 mg dose is unlikely to result in adverse effects in nursing infants and is considered to be compatible with breastfeeding.
Can I drink alcohol with Momento Tablet 5 mg?
Momento Tablet 5 mg alone or in combination with alcohol was safe and well tolerated.
Can I drive after taking Momento Tablet 5 mg?
Do not drive and do not use tools or machines.
When should be taken of Momento Tablet 5 mg?
You can take Momento Tablet 5 mg before or after meals.
Can I take Momento Tablet 5 mg every day?
The recommended dose of Momento Tablet 5 mg tablets is one 5 mg tablet once daily.
How long does Momento Tablet 5 mg take to work?
Momento Tablet 5 mg is also use to relieve the symptoms of allergic skin conditions such as skin itch and hives. Momento Tablet 5 mg usually starts to work within 75 minutes and lasts for 24 hours.
What is the half-life of Momento Tablet 5 mg ?
The 27-hour half-life of Momento Tablet 5 mg permits once daily administration.
How long can I take Momento Tablet 5 mg for?
You can limit treatment to 14 days.
Can I take Momento Tablet 5 mg for a long time?
Momento Tablet 5 mg is unlikely to do you any harm if you take it for a long time. However, it's best to take it only for as long as you need to. It's best not to drink alcohol while you're taking Momento Tablet 5 mg, as it can make you feel sleepy.
Who should not take Momento Tablet 5 mg?
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happen if I overdose of Momento Tablet 5 mg?
tiredness. sleepiness. menstrual pain. Increased sleepiness or tiredness can happen if you take more Momento Tablet 5 mg than your doctor prescribed to you.
Can Momento Tablet 5 mg cause infertility?
Momento Tablet 5 mg is not expected to cause other pregnancy problems.
Does Momento Tablet 5 mg increase blood pressure?
The decongestant in Momento Tablet 5 mg and pseudoephedrine may cause blood pressure to increase and may also speed up the heart rate.
Can Momento Tablet 5 mg affects my kidney?
Older patients are more likely to have kidney or liver problems which may make them more sensitive to the effects of Momento Tablet 5 mg. Your doctor may give you a different Momento Tablet 5 mg dose if you have kidney or liver problems.
