Monobenzone
Monobenzone Uses, Dosage, Side Effects, Food Interaction and all others data.
Monobenzone is the monobenzyl ether of hydroquinone used medically for depigmentation. Monobenzone occurs as a white, almost tasteless crystalline powder, soluble in alcohol and practically insoluble in water. It exerts a depigmenting effect on skin of mammals by increasing the excretion of melanin from the melanocytes. It may also cause destruction of melanocytes and permanent depigmentation.
Monobenzone is the monobenzyl ether of hydroquinone. Monobenzone, applied topically to the skin, is used as a depigmenting agent inhibitting melanin produced by polymerization of oxidation products of tyrosine and dihydroxyphenyl compounds. Monobenzone works by permanently removing color from normal skin located around skin with vitiligo.
| Trade Name | Monobenzone |
| Generic | Monobenzone |
| Monobenzone Other Names | 4-Benzyloxyphenol, Monobenzona, Monobenzone, Monobenzonum, Monobenzyl hydroquinone |
| Type | |
| Formula | C13H12O2 |
| Weight | Average: 200.2332 Monoisotopic: 200.083729628 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Monobenzone is a hydroquinone derivative used to treat vitiligo.
Used topically to treat the loss of skin color (vitiligo).
Monobenzone is also used to associated treatment for these conditions: Skin depigmentation
How Monobenzone works
Monobenzone is a depigmenting agent whose mechanism of action is not fully understood. It is proposed that it increases the excretion of melanin from the melanocytes. This effect is erratic and may take one to four months to occur while existing melanin is lost with normal sloughing of the stratum corneum. Hyperpigmented skin appears to fade more rapidly than does normal skin, and exposure to sunlight reduces the depigmenting effect of the drug. Following skin depigmentation after topical application of monobenzone, the histological studies indicate similar results as that seen in vitiligo, where the epidermis is intact but with the absence of identifiable melanocytes.
Food Interaction
No interactions found.Innovators Monograph
You find simplified version here Monobenzone
