Монокалиевая соль 1-гидроксиэтилидендифосфоновой кислоты дигидрат

Монокалиевая соль 1-гидроксиэтилидендифосфоновой кислоты дигидрат Uses, Dosage, Side Effects, Food Interaction and all others data.

Монокалиевая соль 1-гидроксиэтилидендифосфоновой кислоты дигидрат is a first generation bisphosphonate similar to clodronic acid and tiludronic acid. These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. Etidronate’s use has decreased over the years in favor of the third generation, nitrogen containing bisphosphonate zoledronic acid, ibandronic acid, minodronic acid, and risedronic acid.

Монокалиевая соль 1-гидроксиэтилидендифосфоновой кислоты дигидрат was granted FDA approval on 1 September 1977.

Монокалиевая соль 1-гидроксиэтилидендифосфоновой кислоты дигидрат is a first generation bisphosphonate that inhibits the action of osteoclasts, preventing bone resporption. It has a wide therapeutic index as overdoses are not associated with severe toxicity and a long duration of action as it slowly releases from the bone. Patients should be counselled regarding the risk of upper gastrointestinal adverse reactions.

Trade Name Монокалиевая соль 1-гидроксиэтилидендифосфоновой кислоты дигидрат
Generic Etidronic acid
Etidronic acid Other Names Acetodiphosphonic acid, acide étidronique, ácido etidrónico, acidum etidronicum, EHDP, Etidronate, Etidronic acid, Etidronsäure, HEDP, Hydroxyethanediphosphonic acid, Oxyethylidenediphosphonic acid
Type
Formula C2H8O7P2
Weight Average: 206.0282
Monoisotopic: 205.974525634
Groups Approved
Therapeutic Class
Manufacturer
Available Country Russia
Last Updated: September 19, 2023 at 7:00 am
Монокалиевая соль 1-гидроксиэтилидендифосфоновой кислоты дигидрат
Монокалиевая соль 1-гидроксиэтилидендифосфоновой кислоты дигидрат

Uses

Монокалиевая соль 1-гидроксиэтилидендифосфоновой кислоты дигидрат is a bisphosphonate drug that prevents osteoclastic bone resorption; used for the prevention and treatment of osteoporosis.

Etidronate is indicated to treat Paget's disease of bone, as well as the treatment and prevention of heterotropic ossification after total hip replacement of spinal cord injury.

Монокалиевая соль 1-гидроксиэтилидендифосфоновой кислоты дигидрат is also used to associated treatment for these conditions: Heterotopic Ossification (HO), Paget's Disease of Bone

How Монокалиевая соль 1-гидроксиэтилидендифосфоновой кислоты дигидрат works

Bisphosphonates are taken into the bone where they bind to hydroxyapatite. Bone resorption by osteoclasts causes local acidification, releasing the bisphosphonate, which is taken into the osteoclast by fluid-phase endocytosis. Endocytic vesicles become acidified, releasing bisphosphonates into the cytosol of osteoclasts where they act.

Osteoclasts mediate resorption of bone. When osteoclasts bind to bone they form podosomes, ring structures of F-actin. Disruption of the podosomes causes osteoclasts to detach from bones, preventing bone resorption.

First generation bisphosphonates closely mimic the structure of pyrophosphate, which can be incorporated into ATP anologues that cannot be hydrolyzed, disrupting all ATP mediated actions of osteoclasts.

Toxicity

Patients experiencing an overdose may present with hypocalcemia, vomiting, parasthesia, and diarrhea. Overdose can be treated with symptomatic and supportive treatment that may include management of electrolyte imbalances and intravenous calcium gluconate.

Food Interaction

  • Avoid multivalent ions. Separate administration from multivalent ions by at least two hours.
  • Take on an empty stomach.
  • Take with a full glass of water.

Volume of Distribution

Монокалиевая соль 1-гидроксиэтилидендифосфоновой кислоты дигидрат has a volume of distribution of 0.3-1.3L/kg.

Elimination Route

Монокалиевая соль 1-гидроксиэтилидендифосфоновой кислоты дигидрат has an oral bioavailability of 1-10%. Further data regarding pharmacokinetics of etidronic acid are not readily available.

Half Life

The half life of etidronate is approximately 1-6 hours.

Clearance

Монокалиевая соль 1-гидроксиэтилидендифосфоновой кислоты дигидрат has a renal clearance of 0.09L/kg/h.

Elimination Route

Absorbed etidronic acid is eliminated in the urine, while the unabsorbed drug is eliminated in the feces.

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*** Taking medicines without doctor's advice can cause long-term problems.
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