Monopen

Monopen Uses, Dosage, Side Effects, Food Interaction and all others data.

Benzylpenicillin has a bactericidal action against gram positive bacteria, gram negative cocci, some other gram negative cross-linking stage of peptidoglycan production through binding and inactivation of transpeptidases on the inner surface of the bacterial cell membrane thus inhibiting bacterial cell wall synthesis. It is inhibited by penicillinase and other β-lactamases.

Monopen
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Monopen
Generic	Benzyl Penicillin
Weight	5lac unit/vial, 10lac unit/vial
Type	Injection
Therapeutic Class	Benzylpenicillin & Phenoxymethyl penicillin
Manufacturer	Jayson Pharma Ltd
Available Country	Bangladesh
Last Updated:	September 19, 2023 at 7:00 am

Uses

For use in the treatment of severe infections caused by penicillin G-susceptible microorganisms when rapid and high penicillin levels are required such as in the treatment of septicemia, meningitis, pericarditis, endocarditis and severe pneumonia.

Dosage

Monopen dosage

Adult: Oral: Susceptible infections: 125-312 mg 4-6 hrly.

IM/IV: Susceptible infections: 0.6-3.6 g/day in 4-6 divided doses.

IV:

Bacterial endocarditis: 7.2-12 g/day in divided doses.
Intrapartum prophylaxis against group B Streptoccocal infection in neonates Initial: 3 g, followed by 1.5 g 4 hrly until delivery.
Meningococcal meningitis; Pneumococcal meningitis: 2.4 g 4 hrly. Max: 18 g/day in meningococcal meningitis.

Child:IV: Meningococcal meningitis, Pneumococcal meningitis:

Newborn infants: 100 mg/kg daily in 2 divided doses;
1-4 wk: 150 mg/kg daily in 3 divided doses;
>1 mth to 12 yr: 180-300 mg/kg daily in 4-6 divided doses.

Parenteral: susceptible infections:

Newborn infants: 50 mg/kg daily in 2 divided doses;
1-4 wk: 75 mg/kg daily in 3 divided doses;
>1 mth to 12 yr: 100 mg/kg daily in divided doses, not exceeding 4 g/day.

Loosen the powder, then, hold the vial horizontally and rotate it while slowly directing the stream of diluent against the wall of the vial. Shake the vial vigorously after all the diluent has been added. Depending on the route of admin, reconstitute with sterile water for inj, NaCl 0.9% inj or dextrose 5% inj.

Side Effects

Nausea, vomiting, stomatitis, black or hairy tongue, rash, fever, serum-like sickness, convulsions, interstitial nephritis, haemolytic anaemia, granulocytopenia, agranulocytosis, leucopenia, thrombocytopenia

Precaution

Patient with history of allergy esp β-lactam allergy and/or asthma, seizure disorder. Diabetic patients. Renal impairment. Pregnancy and lactation.

Interaction

May increase the risk of methotrexate toxicity. Increased plasma concentration with probenecid. Antagonism of bactericidal effect with bacteriostatic antibacterials (e.g. erythromycin, tetracyclines).

Pregnancy & Breastfeeding use

Pregnancy category B. Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect that was not confirmed in controlled studies in women in the 1st trimester.

Lactation: Monitor electrolyte, hepatic, renal, cardiac and haematologic function; signs and symptoms of anaphylaxis during 1st dose.