Monopotassium phosphate
Monopotassium phosphate Uses, Dosage, Side Effects, Food Interaction and all others data.
Monopotassium phosphate, MKP, (also potassium dihydrogenphosphate, KDP, or monobasic potassium phosphate), KH2PO4, is a soluble salt of potassium and the dihydrogen phosphate ion. It is a source of phosphorus and potassium as well as a buffering agent. It can be used in fertilizer mixtures to reduce escape of ammonia by keeping pH low.
Potassium is the major cation of intracellular fluid and is essential for maintenance of acid-base balance, isotonicity, and electrodynamic characteristics of the cell. Potassium is an important activator in many enzymatic reactions and is essential to a number of physiologic processes including transmission of nerve impulses; contraction of cardiac, smooth, and skeletal muscles; gastric secretion; renal function; tissue synthesis; and carbohydrate metabolism.Phosphate is a major intracellular anion that participates in providing energy for metabolism of substrates and contributes to important metabolic and enzymatic reactions in almost all organs and tissues. Phosphate exerts a modifying influence on calcium concentrations, a buffering effect on acid-base equilibrium, and has a major role in the renal excretion of hydrogen ions.
| Trade Name | Monopotassium phosphate |
| Generic | Monopotassium phosphate |
| Monopotassium phosphate Other Names | Monobasic potassium phosphate, Monopotassium dihydrogen monophosphate, Monopotassium dihydrogen orthophosphate, Monopotassium dihydrogen phosphate, Monopotassium monophosphate, Monopotassium orthophosphate, Potassium acid phosphate, Potassium biphosphate, Potassium dihydrogen orthophosphate, Potassium dihydrogen phosphate, Potassium phosphate, Potassium phosphate monobasic |
| Type | |
| Formula | H2KO4P |
| Weight | Average: 136.0855 Monoisotopic: 135.932776925 |
| Protein binding | In healthy adults, plasma potassium concentrations generally range from 3.5-5 mEq/L. Plasma concentrations up to 7.7 mEq/L may be normal in neonates. |
| Groups | Approved, Investigational, Vet approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Monopotassium phosphate is an ionic compound used for electrolyte replenishment and total parenteral nutrition (TPN) therapy.
Used in buffers (determination of pH, pharmaceutical production, urinary acidifier, paper processing, baking powder, and food), nutrient solutions, yeast foods, special liquid fertilizers, sonar systems and other electronic applications; Used as a nutritional supplement in foods, a nonlinear optical material for laser use, and in wastewater treatment;
Monopotassium phosphate is also used to associated treatment for these conditions: Fluid replacement therapy, Organ Preservation, Tissue Preservation, Total parenteral nutrition therapy
How Monopotassium phosphate works
hosphorus has a number of important functions in the biochemistry of the body. The bulk of the body's phosphorus is located in the bones, where it plays a key role in osteoblastic and osteoclastic activities. Enzymatically catalyzed phosphate-transfer reactions are numerous and vital in the metabolism of carbohydrate, lipid and protein, and a proper concentration of the anion is of primary importance in assuring an orderly biochemical sequence. ln addition, phosphorus plays an important role in modifying steady-state tissue concentrations of calcium. Phosphate ions are important buffers of the intracellular fluid, and also play a primary role in the renal excretion of the hydrogen ion. Oral administration of inorganic phosphates increases serum phosphate levels. Phosphates lower urinary calcium levels in idiopathic hypercalciuria.
Toxicity
Rabbit : LD50 >4640mg/kg (skin) Rat : LdLo : 4640mg/kg (Oral)
Food Interaction
- Take separate from antacids. Magnesium, calcium, or aluminum antacids may reduce the absorption of phosphate in K-phos.
- Take with a full glass of water. Dissolve K-Phos tablets in water then ingest.
- Take with food. Take K-Phos tablets at bedtime and with meals.
Volume of Distribution
Potassium first enters the extracellular fluid and is then actively transported into the cells where its concentration is up to 40 times that outside the cell. Dextrose, insulin, and oxygen facilitate movement of potassium into cells.
Elimination Route
Potassium salts are well absorbed from the GI tract. Ingested phosphates are absorbed from the gastrointestinal tract. However, the presence of large amounts of calcium or aluminum may lead to formation of insoluble phosphate and reduce the net absorption. Vitamin D stimulates phosphate absorption.
Half Life
In healthy children with phosphate overdose, half-life was 4.8 to 10.6 hours, and was prolonged to 17 hours in a child with renal insufficiency.
Clearance
Phosphates are rapidly cleared by dialysis. Dialysis can also be used to treat other electrolyte abnormalities such as hypernatremia, hypocalcemia, and hypomagnesemia.
Elimination Route
Renal (90%) and fecal (10%) Phosphates Potassium is excreted mainly by the kidneys. Small amounts of potassium may be excreted via the skin and intestinal tract, but most of the potassium excreted into the intestine is later reabsorbed.
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