Moodi
Moodi Uses, Dosage, Side Effects, Food Interaction and all others data.
Moodi is a pyridylbenzodiazepine compound with anxiolytic properties. In low dosage, it diminishes anxiety, tension and nervousness. In high dosage, the sedative and muscle-relaxant properties appear.
Moodi is a lipophilic, long-acting benzodiazepine and with sedative, hypnotic, anxiolytic and skeletal muscle relaxant properties. It does not possess any antidepressant qualities. Moodi, like other benzodiazepines, presents a risk of abuse, misuse, and dependence. According to many psychiatric experts, Moodi has a greater abuse potential than other benzodiazepines because of fast resorption and rapid onset of action.
| Trade Name | Moodi |
| Generic | Bromazepam |
| Bromazepam Other Names | Bromacepam, Bromazepam, Bromazepamum |
| Weight | 3mg |
| Type | Tablet |
| Formula | C14H10BrN3O |
| Weight | Average: 316.153 Monoisotopic: 315.000724604 |
| Protein binding | 70% |
| Groups | Approved, Illicit, Investigational |
| Therapeutic Class | Benzodiazepine sedatives |
| Manufacturer | Saydon Pharmaceutical Industries (pvt) Ltd, |
| Available Country | Pakistan |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Moodi is used for the following diseases:
* Emotional disturbances: Anxiety and tension states, as adjuvant therapy for anxiety in depressed patients, nervous tension, restlessness, and anxiety- and tension- related insomnia. As an adjuvant to treatment of underlying disease responsible for functional or psychosomatic impairments of various organs caused by anxiety and tension.
* Cardiovascular and respiratory systems: Pseudoangina pectoris, precordial anxiety, tachycardia, emotiogenic hypertension, dyspnea, and hyperventilation.
* Gastrointestinal tract: Irritable bowel syndrome, ulcerative colitis, epigastric pain, spasm, meteorism, and diarrhoea.
* Urogenital tract: Irritable bladder, urinary frequency and dysmenorrhea.
* Other psychosomatic disturbances: Psychogenic headache, psychogenic dermatoses.
Moodi is suitable for treatment of anxiety and tension states due to chronic organic disease and as an adjuvant to psychotherapy in psychoneurosis.
Moodi is also used to associated treatment for these conditions: Acute Anxiety, Severe Anxiety
How Moodi works
Moodi binds to the GABA-A receptor producing a conformational change and potentiating its inhibitory effects. Other neurotransmitters are not influenced.
Dosage
Moodi dosage
Adults: The optimum dosage and frequency of administration of Moodi is based on the individual patient, the severity of symptoms and previous psychotropic drug history.
Average dose for outpatient therapy: 1.5 - 3 mg 3 times daily.
Severe cases, especially in hospitals: 6 - 12 mg 2 - 3 times daily.
Treatment of outpatients should begin with low doses, gradually increasing to the optimum level. In general, the total duration of treatment should not exceed 8-12 weeks including a tapering-off period. In certain cases, treatment may need to be continued beyond the maximum recommended duration but only after a careful reassessment of the patient's condition and indications.
Elderly patients: Doses should not exceed half those normally recommended.
Children: Moodi is not for paediatric use.
Moodi tablets are for oral administration
Side Effects
Common side effects include drowsiness, sedation, unsteadiness and ataxia. These are dose-related and may persist into the following day, even after a single dose. Other side effects are rare and include headache, vertigo, hypotension, gastrointestinal upsets, skin rashes, visual disturbances and urinary retention.
Precaution
In patients with chronic pulmonary insufficiency, and in patients with chronic renal or hepatic disease, dosage may need to be reduced.
Moodi should not be used alone to treat depression or anxiety associated with depression.
Moodi should be used with extreme caution in patients with a history of alcohol or drug abuse.
Interaction
Phenothiazines, barbiturates, MAO inhibitors and psychoactive drugs may potentiate the action of Moodi and should not be given concurrently.
Food Interaction
- Avoid alcohol. Ingesting alcohol may increase the sedative and CNS depressant effects of bromazepam.
- Take with or without food. Taking bromazepam with food may reduce its Cmax and AUC.
Volume of Distribution
1.56 L/kg
Elimination Route
Bioavailability is 84% following oral administration. The time to peak plasma level is 1 - 4 hours. Moodi is generally well absorbed after oral administration.
Half Life
10-20 hours
Clearance
0.82 mL/min/kg.
Elimination Route
Urine (69%), as metabolites
Pregnancy & Breastfeeding use
Pregnancy: The safety of Moodi in pregnant women has not been established. Moodi should not be used during pregnancy, especially during the first and last trimesters, unless there are compelling reasons.
Lactation: Benzodiazepines have been detected in breast milk. If possible, the use of Moodi should be avoided during lactation.
Contraindication
Patients with known hypersensitivity to benzodiazepines; acute pulmonary insufciency; respiratory depression phobic or obsessional states; chronic psychosis.
Acute Overdose
Manifestations of overdosage include somnolence, confusion, and respiratory and cardiovascular depression with coma in severe cases.
Interaction with other Medicine
If Moodi is combined with other centrally acting drugs, such as neuroleptics, tranquilizers, antidepressants, hypnotics, narcotic analgesics and anaesthetics, its CNS sedation effect may be increased.
Storage Condition
Store in a cool dry place protected from light. Keep out of reach of children.
Innovators Monograph
You find simplified version here Moodi
FAQ
What is Moodi used for?
Moodi is mainly an anti-anxiety agent with similar side effects to Moodi. In addition to being used to treat anxiety or panic states, bromazepam may be used as a premedicant prior to minor surgery.
How safe is Moodi?
If not taken in accordance with a doctor's instructions, Moodi can cause serious physical harm and even lead to a fatal overdose, whilst using it for any length of time also exposes you to the risk of addiction.
What are the common side effects of Moodi?
Moodi is similar in side effects to other benzodiazepines. The most common side effects reported are drowsiness, sedation, ataxia, memory impairment, and dizziness.
How does Moodi work?
Moodi works to reduce anxiety by affecting certain substances in the brain called neurotransmitters.
Is Moodi safe in pregnancy?
If Moodi treatment is necessary during the last part of pregnancy, high doses should be avoided and withdrawal symptoms and/or floppy infant syndrome should be monitored in newborn.
Is Moodi safe in breastfeeding?
Moodi may be excreted into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.
Can I drink with Moodi?
People taking this medication should not consume alcohol since doing so can reduce the effectiveness of this medication and increase the risk of side effects.
Can I drive after taking Moodi?
Do not drive or operate machinery until you know how Moodi affects you. Moodi may cause drowsiness or dizziness in some people and therefore may affect alertness.
How much Moodi can I take daily?
Generally, the maximum adult dose of Moodi is 30 mg daily in divided doses. The usual dose is between 6 to 12 mg daily.
How long does it take for Moodi to take effect?
The time to peak plasma level is 1 - 4 hours. Moodi is generally well absorbed after oral administration.
How long do Moodi effects last?
Moodi have intermediate durations of action and may be detectable in the system for five days.
How much Moodi should I take to sleep?
Moodi was administered in a single dose of 1.5 mg one-half hour before bedtime to study its short-term action and the effect of its discontinuation on the sleep of 6 children suffering from night terrors.
How long should I take Moodi?
Moodi should be taken for short periods only (for example 2 to 4 weeks), unless advised otherwise by your doctor.
Who should not take Moodi?
Moodi is not recommended for use by children or adolescents under 18 years of age. Seniors: Seniors may be at increased risk of experiencing the sedative and impaired coordination effects of Moodi. They need to exercise extra caution, for example, to avoid falling when getting up during the night.
Can Moodi cause depression?
Depression: Moodi, like other benzodiazepines, has been known to cause mood swings and symptoms of depression.
Can Moodi cause high blood pressure?
In mild hypertensive patients, evening consumption of Moodi for a 2-week period did not affect BP, while it increased nocturnal HR.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention. An overdose of clonazepam can be fatal if you take it with alcohol, opioid medicine, or other drugs that cause drowsiness or slow your breathing. Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, or coma.
Are Moodi bad for my kidneys?
Mixed with prescription muscle relaxers, Moodi can also damage liver and kidney function.
Can Moodi affects my liver?
During the chronic administration, the liver weight increased 30-40%, with concomitant enlargement of the liver.
Do Moodi affect fertility?
Moodi can affect fertility in a variety of ways.
