Moricizine

Moricizine Uses, Dosage, Side Effects, Food Interaction and all others data.

An antiarrhythmia agent used primarily for ventricular rhythm disturbances.

Moricizine is used to treat irregular heartbeats (arrhythmias) and to maintain a normal heart rate. It acts on the heart muscle to improve the heart's rhythm. Moricizine has potent local anesthetic activity and membrane stabilizing effect. Decreases excitability, conduction velocity, and automaticity as a result of slowed atrioventricular (AV) nodal and His-Purkinje conduction. Decreases the action potential duration (APD) in Purkinje fibers; also decreases the effective refractory period (ERP) but to a lesser extent than the APD, so the ERP/APD ratio is increased. Decreases the maxiumum rate of Phase 0 depolarization (V max ), but does not affect action potential amplitude or maximum diastolic potential. Does not affect atrial, AV nodal, or left ventricular refractory periods and has minimal effect on ventricular repolarization (evidenced by the overall decrease in JT interval). Has no effect on sinoatrial (SA) nodal or intra-atrial conduction and only minimal effect on sinus cycle length and sinus node recovery time. In the Vaughan Williams classification of antiarrhythmics, moricizine is considered to be a class I agent. It has properties of class IA, IB, and IC agents but does not clearly belong to any of the three subclasses. It has less effect on the slope of phase 0 and a greater effect on action potential duration and effective refractory period than class IC agents.

Moricizine
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Moricizine
Availability	Discontinued
Generic	Moricizine
Moricizine Other Names	Ethmozin, Etmozin, Moracizin, Moracizina, Moracizine, Moracizinum, Moricizine
Related Drugs	propranolol, atenolol, amiodarone, lidocaine, verapamil, flecainide, Tenormin, Inderal, dofetilide
Type
Formula	C₂₂H₂₅N₃O₄S
Weight	Average: 427.517 Monoisotopic: 427.156576993
Protein binding	Approximately 95%.
Groups	Approved, Investigational, Withdrawn
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Moricizine is an antiarrhythmic used to treat arrhythmias.

Used to treat irregular heartbeats (arrhythmias) and maintain a normal heart rate.

How Moricizine works

Moricizine works by inhibiting the rapid inward sodium current across myocardial cell membranes.

Toxicity

Symptoms of overdose include vomiting, unconsciousness, and severe low blood pressure.

Moricizine Drug Interaction

Unknown: charcoal, charcoal, atropine ophthalmic, atropine ophthalmic, fenofibrate, fenofibrate, valproic acid, valproic acid

Moricizine Disease Interaction

Major: cardiovascular dysfunction, proarrhythmic effectsModerate: electrolyte imbalance

Volume of Distribution

300 L

Elimination Route

Well absorbed, absorption is complete within 2 to 3 hours. Significant first-pass metabolism results in an absolute bioavailability of approximately 38%. Administration within 30 minutes after a meal slows the rate, but does not affect the extent of absorption, although peak plasma concentrations are reduced.

Half Life

2 hours (range 1.5-3.5 hours).

Elimination Route

Less than 1% of orally administered Ethmozine® is excreted unchanged in the urine. Approximately 56% of the administered dose is excreted in the feces and 39% is excreted in the urine.