Morr Forte

Morr Forte Uses, Dosage, Side Effects, Food Interaction and all others data.

Morr Forte stimulates hair growth by increasing oxygen, blood and nutrients supply to the hair follicle by widening blood vessels and inhibiting androgen hormone to affect hair follicles.

Following topical application, an average of about 1.4% of the total applied dose is absorbed from the normal intact scalp. Topical Morr Forte absorption is increased by increasing the dose applied, increasing the frequency of dosing and decreasing the barrier function of the stratum corneum. Serum Morr Forte levels and systemic effects resulting from the administration of topical Morr Forte are governed by the drug’s absorption rate through the skin. Following cessation of topical dosing, approximately 95% of the systemically absorbed drug is eliminated within 4 days. Morr Forte and its metabolites are excreted principally in the urine.

Morr Forte is an orally effective direct acting peripheral vasodilator that reduces elevated systolic and diastolic blood pressure by decreasing peripheral vascular resistance. Morr Forte is also used topically to treat androgenetic alopecia. Microcirculatory blood flow in animals is enhanced or maintained in all systemic vascular beds. In man, forearm and renal vascular resistance decline; forearm blood flow increases while renal blood flow and glomerular filtration rate are preserved. The predominant site of minoxidil action is arterial. Venodilation does not occur with minoxidil; thus, postural hypotension is unusual with its administration. The antihypertensive activity of minoxidil is due to its sulphate metabolite, minoxidil sulfate.

Trade Name Morr Forte
Availability Prescription only
Generic Minoxidil
Minoxidil Other Names Minossidile, Minoxidil, Minoxidilum
Related Drugs amlodipine, lisinopril, metoprolol, losartan, furosemide, hydrochlorothiazide
Type Lotion
Formula C9H15N5O
Weight Average: 209.2483
Monoisotopic: 209.127660127
Protein binding

Minoxidil does not bind to plasma proteins.

Groups Approved, Investigational
Therapeutic Class Other scalp preparations
Manufacturer Intas Pharmaceuticals Ltd
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Morr Forte
Morr Forte

Uses

Morr Forte is used for the treatment of androgenic alopecia in males and females and stabilisation of hair loss in patients with androgenic alopecia, and also of alopecia areata.

Morr Forte is also used to associated treatment for these conditions: Androgenetic Alopecia, Severe, symptomatic Hypertension

How Morr Forte works

Morr Forte is thought to promote the survival of human dermal papillary cells (DPCs) or hair cells by activating both extracellular signal-regulated kinase (ERK) and Akt and by preventing cell death by increasing the ratio of BCl-2/Bax. Morr Forte may stimulate the growth of human hairs by prolonging anagen through these proliferative and anti-apoptotic effects on DPCs. Morr Forte, when used as a vasodilator, acts by opening adenosine triphosphate-sensitive potassium channels in vascular smooth muscle cells. This vasodilation may also improve the viability of hair cells or hair follicles.

Dosage

Morr Forte dosage

Morr Forte topical solution is for external use only and should be applied when the hair and scalp are clean and dry. Apply 1 ml (7 sprays) of Morr Forte topical solution twice daily at 12-hour intervals to the scalp, beginning at the centre of the affected area and spreading the solution out to cover the entire affected area. The total daily application dose should not exceed 2 ml.

For the best results, Morr Forte topical solution should be allowed to remain on the scalp for about 4 hours before washing. The night-time application should be done 2-4 hours before going to bed to allow the solution to dry out. Morr Forte topical solution should not be massaged into the scalp, but applied lightly. A hair dryer should not be used to speed up the drying of the solution as it may decrease the effectiveness. Morr Forte topical solution should not be mixed with any hair oil. The drug should not be used more than two times a day, or be taken orally or applied to any other part of the body to avoid the risk of adverse effects and unwanted hair growth. More frequent use or longer application time have no effect on hair growth. In case of missing any daily applications of Morr Forte topical solution, the patient should continue with the next application.

Hands should be washed immediately if Morr Forte topical solution is applied with the fingertips. Clinical experience with Morr Forte indicates that twice-daily applications for 4 months or more may be required before there is evidence of hair growth. To arresthair fall, Morr Forte topical solution should be used for not less than 45 days. Depending upon the severity of hair loss or type and extent of baldness, particular strength of Morr Forte topical solution may be selected.

Side Effects

Commonly encountered side effects in clinical trials with Morr Forte topical solution were minor dermatological reactions. Dermatitis or hypertrichosis may occur. These incidences may occur in 0.1–5% of patients.

Toxicity

Oral LD50 in rats has ranged from 1321-3492 mg/kg; in mice, 2456-2648 mg/kg. Side effects include cardiovascular effects associated with hypotension such as sudden weight gain, rapid heart beat, faintness or dizziness.

Precaution

Morr Forte topical solution is more likely to cause scalp irritation. If scalp irritation continues or worsen, use of Morr Forte topical solution should be stopped.

Interaction

Morr Forte topical solution should not be used along with other topical agents known to alter the stratum corneum barrier such as tretinoin or dithranol, due to the enhanced absorption of Morr Forte. Although there is no clinical evidence, there exists the theoretical possibility of absorbed Morr Forte potentiating orthostatic hypotension caused by peripheral vasodilators.

Food Interaction

  • Take with or without food. The absorption is unaffected by food.

Elimination Route

Morr Forte is at least 90% absorbed from the GI tract in experimental animals and man.

Half Life

4.2 hours

Pregnancy & Breastfeeding use

Morr Forte topical solution should not be used during pregnancy and lactation.

Contraindication

  • Patients with cardiac abnormalities
  • Children below 18 years of age
  • Patients using occlusive dressings or other medicines on the scalp
  • Patients with red, inflamed infection, or irritated or painful scalp (including psoriasis & sunburn)

Acute Overdose

Increased systemic absorption of Morr Forte may potentially occur if higher-than-recommended doses of Morr Forte are applied to larger surface areas of the body or areas other than the scalp. There are no known cases of Morr Forte overdosage resulting from topical administration of Morr Forte.

Signs and symptoms of Morr Forte overdosage would primarily be cardiovascular effects associated with sodium and water retention, and tachycardia. Fluid retention can be managed with appropriate diuretic therapy. Clinically significant tachycardia can be controlled by administration of a beta-adrenergic blocking agent.

Storage Condition

Store at a cool and dry place, protected from light. Keep out of the reach of the children.

Innovators Monograph

You find simplified version here Morr Forte

Morr Forte contains Minoxidil see full prescribing information from innovator Morr Forte Monograph, Morr Forte MSDS, Morr Forte FDA label

FAQ

What is Morr Forte used for?

Morr Forte is a medication used for the treatment of high blood pressure and pattern hair loss in males and females. Morr Forte applied to the scalp is used to stimulate hair growth in adult men and women with a certain type of baldness.

How safe is Morr Forte?

This over-the-counter product is considered safe, but should be used with caution. Furthermore,  Morr Forte is an orally active vasodilator for treatment of severe hypertension.

How does Morr Forte work?

works by shortening the telogen phase of your hair growth cycle and moving your hairs into the anagen.

What are the common side effects of Morr Forte?

Common side effects of Morr Forte are include:

  • Irritation
  • Eczema
  • Abnormal hair growth on the body
  • Allergic contact dermatitis
  • Application site redness
  • Worsening of hair loss
  • Burning
  • Respiratory infections
  • Tendinitis
  • Back pain
  • Fractures
  • Sinusitis
  • Fluid retention (edema)
  • Anxiety
  • Low blood pressure (hypotension)
  • Dizziness
  • Lightheadedness
  • Faintness

Is Morr Forte safe during pregnancy?

It is not known whether Morr Forte topical will harm an unborn baby. Do not use this medicine without a doctor's advice if you are pregnant. Morr Forte should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby.

Is Morr Forte safe during breastfeeding?

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Can I drink alcohol with Morr Forte?

Morr Forte does not significantly react with alcohol use. However, alcohol can dry out the skin, which could irritate your scalp when using topical Morr Forte products.

When should be taken of Morr Forte?

Morr Forte is a topical medication that you apply directly to your scalp. It's designed for use two times a day. Most people who use Morr Forte apply it once in the morning and once in the evening, typically a few hours before going to bed.

Can I take Morr Forte on an empty stomach?

Morr Forte may be taken with food or on an empty stomach.

How long can I take Morr Forte?

Most people need to use this medication regularly for 4 months to see benefit. This medication must be used continuously to maintain hair growth. If your condition does not improve or worsens after using this medication for 4 to 6 months.

Is Morr Forte bad for the heart?

Morr Forte can cause poor heart function or worsen existing heart problems.

How long does Morr Forte take to work?

Generally speaking, it takes about 8 weeks of consistent use to start to see results with Morr Forte. After 4 months of use, you should start to see the end of hair loss and start to see hair growth.

How long does Morr Forte stay in my system?

After an effective single oral dose, blood pressure usually starts to decline within one-half hour, reaches a minimum between 2 and 3 hours and recovers at an arithmetically linear rate of about 30%/day. The total duration of effect is approximately 75 hours.

What happens If I stop taking Morr Forte?

If you stop applying Morr Forte to your scalp, you'll gradually lose any hair that you've regrown as a result of the medication. Morr Forte is a well-studied medication that's safe to use for the long term.

Who should not take Morr Forte?

Do not use Morr Forte topical if the skin on your scalp is red, swollen, irritated, or infected.

What happens if I miss a dose?

Apply the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

An overdose of Morr Forte topical is not expected to be dangerous. Seek emergency medical attention if anyone has accidentally swallowed the medication.

Can Morr Forte affects my heart ?

Morr Forte can cause poor heart function or worsen existing heart problems.

Can Morr Forte affect my kidneys?

If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure.

Can Morr Forte affects my liver?

Morr Forte is metabolized by the liver, but has little effect on hepatic metabolism of other drugs. The reason for its lack of hepatotoxicity is not known.

Will Morr Forte affect my fertility?

There is accumulating evidence that it negatively impacts male fertility. You may instead use topical Morr Forte, which has no known negative effects on male fertility.

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0004707
http://classyfire.wishartlab.com/tax_nodes/C0000278
http://classyfire.wishartlab.com/tax_nodes/C0002449
http://classyfire.wishartlab.com/tax_nodes/C0003901
http://classyfire.wishartlab.com/tax_nodes/C0001262
http://classyfire.wishartlab.com/tax_nodes/C0000195
http://classyfire.wishartlab.com/tax_nodes/C0003886
http://classyfire.wishartlab.com/tax_nodes/C0004144
http://classyfire.wishartlab.com/tax_nodes/C0004139
http://classyfire.wishartlab.com/tax_nodes/C0002450
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:6942
http://www.hmdb.ca/metabolites/HMDB0014494
http://www.genome.jp/dbget-bin/www_bget?drug:D00418
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4201
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508344
https://www.chemspider.com/Chemical-Structure.10438564.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50237593
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=6984
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=6942
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL802
https://zinc.docking.org/substances/ZINC000000001735
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000143
http://www.pharmgkb.org/drug/PA450521
http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4254
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/MXD
http://www.rxlist.com/minoxidil-drug.htm
https://www.drugs.com/cdi/minoxidil.html
https://en.wikipedia.org/wiki/Minoxidil
*** Taking medicines without doctor's advice can cause long-term problems.
Share