Moxizest
Moxizest Uses, Dosage, Side Effects, Food Interaction and all others data.
Moxizest is a synthetic broad spectrum, flouroquinolone derivative antibacterial agent. Moxizest has in vitro activity against a wide range of Gram-positive and Gram-negative microorganisms. The bactericidal action of Moxizest results from inhibition of the topoisomerase II (DNA gyrase) and topoisomerase IV required for bacterial DNA replication, transcription, repair and recombination.
Moxizest is a quinolone/fluoroquinolone antibiotic. Moxizest can be used to treat infections caused by the following bacteria: Aerobic Gram-positive microorganisms: Corynebacterium species, Micrococcus luteus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus warneri, Streptococcus pneumoniae, and Streptococcus viridans group. Aerobic Gram-negative microorganisms: Acinetobacter lwoffii, Haemophilus influenzae, and Haemophilus parainfluenzae. Other microorganisms: Chlamydia trachomatis.Moxizest is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian. Moxizest is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.
| Trade Name | Moxizest |
| Availability | Prescription only |
| Generic | Moxifloxacin |
| Moxifloxacin Other Names | Moxifloxacin, Moxifloxacino |
| Related Drugs | amoxicillin, prednisone, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, ceftriaxone, levofloxacin |
| Type | Eye Drops, Tablet, Infusion, Capsule |
| Formula | C21H24FN3O4 |
| Weight | Average: 401.4314 Monoisotopic: 401.175084476 |
| Protein binding | 50% bound to serum proteins, independent of drug concentration. |
| Groups | Approved, Investigational |
| Therapeutic Class | 4-Quinolone preparations |
| Manufacturer | Innovative Pharmaceuticals |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Moxizest is used for the treatment of adults (>18 years of age) with infections caused by susceptible strains of the designated microorganisms in the conditions listed below-
- Acute Bacterial Sinusitis caused by Streptococcus pneumoniae, Haemophilus infuenzae or Moraxella catarrhalis.
- Acute Bacterial Exacerbation of Chronic Bronchitis caused by Streptococcus pneumoniae, Haemophilus infuenzae, Haemophilus parainfuenzae, Klebsiella pneumoniae, methicillin-susceptible Staphylococcus aureus or Moraxella catarrhalis
- Community Acquired Pneumonia caused by Streptococcus pneumoniae (including multi-drug resistant strains), Haemophilus infuenzae, Moraxella catarrhalis, methicillin-susceptible Staphylococcus aureus, Klebsiella pneumoniae, Mycoplasma pneumoniae or Chlamydophilia pneumoniae.
- Uncomplicated Skin and Skin Structure Infections caused by methicillin-susceptible Staphylococcus aureus or Streptococcus pyogen.
- Complicated Skin and Skin Structure Infections caused by methicillin-susceptible Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae or Enterobacter cloacae.
- Complicated Intra-Abdominal Infections including polymicrobial infections such as abscess caused by Escherichia coli, Bacteroides fragilis, Streptococcus anginosus, Streptococcus constellatus, Enterococcus faecalis, Proteus mirabilis, Clostridium perfringens, Bacteroides thetaiotaomicron or Peptostreptococcus species.
Moxizest is also used to associated treatment for these conditions: Acute Exacerbation of Chronic Bronchitis (AECB), Bacterial Conjunctivitis, Community Acquired Pneumonia (CAP), Plague, Postoperative Inflammatory Response, Sinusitis, Skin Infections, Ocular bacterial infections, Post-operative infection
How Moxizest works
The bactericidal action of moxifloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV. DNA gyrase is an essential enzyme that is involved in the replication, transcription and repair of bacterial DNA. Topoisomerase IV is an enzyme known to play a key role in the partitioning of the chromosomal DNA during bacterial cell division.
Dosage
Moxizest dosage
The dose of Moxizest is 400 mg once every 24 hours. The duration of therapy depends on the type of infection as described bellow-
- In Acute Bacterial Sinusitis: Moxizest 400 mg is given once daily for 10 days.
- In Acute Bacterial Exacerbation of Chronic Bronchitis: Moxizest 400 mg is given once daily for 5 days.
- In Community Acquired Pneumonia: Moxizest 400 mg is given once daily for 7-14 days.
- In Uncomplicated Skin & Skin Structure infections: Moxizest 400 mg is given once daily for 7 days.
- In Complicated Skin & Skin Structure infections: Moxizest 400 mg is given once daily for 7-21 days.
- In Complicated Intra-Abdominal infections: Moxizest 400 mg is given once daily for 5-14 days.
Moxizest 400 mg IV infusion can be administered intravenously for the entire treatment duration. Alternatively, therapy may be initial intravenous administration, followed by oral administration when clinically indicated. The recommended duration of treatment for the indication being treated should not be exceeded. The solution for infusion should be infused intravenously over 60 minutes.
Side Effects
The following one or more side effects may be observed: tendinopathy and tendon rupture, QT prolongation, hypersensitivity reactions, Clostridium difficile-associated diarrhea, peripheral neuropathy, photosensitivity, phototoxicity etc.
Toxicity
Symptoms of overdose include CNS and gastrointestinal effects such as decreased activity, somnolence, tremor, convulsions, vomiting, and diarrhea. The minimal lethal intravenous dose in mice and rats is 100 mg/kg.
Precaution
Moxizest should be discontinued at the first appearance of a skin rash or any other sign of hypersensitivity. Moxizest should be discontinued if the patient experiences pain, swelling, inflammation or rupture of a tendon.
Interaction
No quinolone should be co-administered with any solution containing multivalent cations (e.g. magnesium) through the same intravenous line. Antacids, iron and adsorbents reduce absorption of Moxizest. NSAID may increase the risk of CNS stimulation. Warfarin may increase the risk of bleeding.
Food Interaction
- Drink plenty of fluids.
- Take with or without food.
Moxizest multivitamins interaction
[Moderate] ADJUST DOSING INTERVAL: Oral preparations that contain magnesium, aluminum, or calcium may significantly decrease the gastrointestinal absorption of quinolone antibiotics.
Absorption may also be reduced by sucralfate, which contains aluminum, as well as other polyvalent cations such as iron and zinc.
The mechanism is chelation of quinolones by polyvalent cations, forming a complex that is poorly absorbed from the gastrointestinal tract.
The bioavailability of ciprofloxacin has been reported to decrease by as much as 90% when administered with antacids containing aluminum or magnesium hydroxide.
When coadministration cannot be avoided, quinolone antibiotics should be dosed either 2 to 4 hours before or 4 to 6 hours after polyvalent cation-containing products to minimize the potential for interaction.
When coadministered with Suprep Bowel Prep (magnesium Please consult individual product labeling for specific recommendations.
Moxizest Drug Interaction
Moderate: aspirin, aspirin, aspirin, celecoxib, albuterol / ipratropium, budesonide / formoterolUnknown: amoxicillin / clavulanate, diphenhydramine, ubiquinone, duloxetine, omega-3 polyunsaturated fatty acids, furosemide, atorvastatin, metoprolol, acetaminophen, acetaminophen, cyanocobalamin, pyridoxine, ascorbic acid, cholecalciferol
Moxizest Disease Interaction
Major: colitis, liver disease, CNS disorders, myasthenia gravis, peripheral neuropathy, QT interval prolongation, tendonitisModerate: crystalluria, diabetes
Volume of Distribution
- 1.7 to 2.7 L/kg
Elimination Route
Well absorbed from the gastrointestinal tract. Absolute oral bioavailability is approximately 90%. Food has little effect on absorption.
Half Life
11.5-15.6 hours (single dose, oral)
Clearance
- 12 +/- 2 L/hr
Elimination Route
Approximately 45% of an oral or intravenous dose of moxifloxacin is excreted as unchanged drug (~20% in urine and ~25% in feces).
Pregnancy & Breastfeeding use
Pregnancy Category C. Moxizest is not recommended during pregnancy & lactation.
Contraindication
Moxizest is contraindicated in persons with a history of hypersensitivity to Moxizest or any member of the quinolone class of antimicrobial agents and any component of this formulation.
Special Warning
Elderly: No adjustment of dosage is required in the elderly.
Children: Efficacy and safety of Moxizest IV infusion in children and adolescent have not been established.
Acute Overdose
In the events of an acute overdose, the stomach should be emptied. The patient should be kept under observation and appropriate hydration should be maintained.
Storage Condition
Store between 15 to 30° C. Protect from light and moisture. Keep away from reach of children.
Innovators Monograph
You find simplified version here Moxizest
Moxizest contains Moxifloxacin see full prescribing information from innovator Moxizest Monograph, Moxizest MSDS, Moxizest FDA label
FAQ
What is Moxizest used for?
Moxizest is used to treat certain infections caused by bacteria such as pneumonia, and skin, and abdominal (stomach area) infections.Moxizest is also used to prevent and treat plague a serious infection that may be spread on purpose as part of a bioterror attack.
How safe is Moxizest?
Moxizest may cause problems with bones, joints, and tissues around joints in children.Moxizest should not be given to children younger than 18 years old.Moxizest may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.
How does Moxizest work?
Moxizest works by killing the bacteria that cause infections. Antibiotics such as Moxizest will not work for colds, flu, or other viral infections.
What are the common side effects of Moxizest?
The common side effects of Moxizest are include:
- nausea.
- vomiting.
- stomach pain.
- diarrhea.
- constipation.
- heartburn
Is Moxizest safe during pregnancy?
Use is considered acceptable; according to some experts,this drug should be used during pregnancy only if the benefit outweighs the risk to the fetus.
Is Moxizest safe during breastfeeding?
Use of Moxizest is acceptable in nursing mothers with monitoring of the infant for possible effects on the gastrointestinal flora, such as diarrhea or candidiasis..Moxizest is preferable to use an alternate drug for which safety information is available.
Can I drink alcohol with Moxizest?
Do not drink alcohol. Drinking alcohol can increase the chance of liver problems while you are taking Moxizest. Avoid hard physical activity. Although not common, Moxizest can make it easier to get tendon injuries.
Can I drive after taking Moxizest?
Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
What is the best time to take Moxizest?
Moxizest is usually taken with or without food once a day for 5 to 21 days. The length of treatment depends on the type of infection being treated. Your doctor will tell you how long to take Moxizest. Take Moxizest at around the same time every day.
Can I take Moxizest at night?
Take Moxizest exactly as your doctor tells you to. You will be prescribed a dose of one tablet a day. Try to take the tablets at the same time of day each day, as this will help you to remember to take Moxizest regularly.
Is Moxizest a good antibiotic?
Normally, Moxizestis not a dangerous antibiotic for most people, but in rare cases, it can cause serious side effects such as heart rhythm problems, liver damage, and tendon rupture.
Does Moxizest make me sleepy?
Moxizest may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally.
Can Moxizest cause blurry vision?
Moxizest ophthalmic may cause blurred vision and may impair your reactions. Avoid driving or hazardous activity until you know how this medicine will affect you.
Can Moxizest increase heart rate?
Moxizest causes increase heart rate greater than 10 bpm.
How often can I use Moxizest?
Moxizest is usually used three times a day for 7 days. Try to use at around the same times every day.
Can I overdose on Moxizest?
An overdose of Moxizest ophthalmic is not expected to be dangerous. Seek emergency medical attention if anyone has accidentally swallowed the medication. Do not use other eye medications unless your doctor tells you to.
Can Moxizest cause permanent damage?
Moxizest can cause long-lasting, disabling and potentially permanent side effects involving tendons, muscles, joints and the nervous system.
How long does btrand stay in my body?
The elimination half-life of Moxizest is 11.5 to 15.6 hours .About 45% of an oral or intravenous dose of Moxizest is excreted as unchanged drug.
Can I take Moxizest for a long time?
Moxizest oral tablet is used for short-term treatment.
How long can I take Moxizest?
Moxizest comes as tablet to take by mouth.Moxizest is usually taken with or without food once a day for 5 to 21 days. The length of treatment depends on the type of infection being treated.
Who should Moxizest take Moxizest?
Stop using Moxizest and call your doctor at once if you have symptoms such as:headache, hunger, irritability, numbness, tingling, burning pain, confusion, agitation, paranoia, problems with memory or concentration, thoughts of suicide, or sudden pain or movement problems in any of your joints.
