Multilind Pâte Curative
Multilind Pâte Curative Uses, Dosage, Side Effects, Food Interaction and all others data.
Multilind Pâte Curative has fungistatic or fungicidal activity against variety of pathogenic and nonpathogenic yeast and fungi, including Candida albicans. Multilind Pâte Curative exerts its antifungal activity by binding to sterols in the fungal cell membrane. As a result of binding, the membrane is no longer able to function as a selective barrier, and potassium and other cellular constituents are lost. It is poorly absorbed from the gastrointestinal tract.
Multilind Pâte Curative is an antifungal that is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi. It exerts its antifungal effects via disruption of the fungal cell membrane. Resistance to nystatin is minimal in Candida albicans, but tends to develop in other species of Candida. Multilind Pâte Curative carries no significant activity against bacteria, protozoa, or viruses. It carries significant systemic toxicity and is currently unavailable in a formula appropriate for systemic use - its efficacy is currently restricted, therefore, to topical, oral, and gastrointestinal infections.
| Trade Name | Multilind Pâte Curative |
| Availability | Prescription only |
| Generic | Nystatin |
| Nystatin Other Names | Nistatina, Nystatin, Nystatine, Nystatinum |
| Related Drugs | fluconazole, clotrimazole, Diflucan, itraconazole, miconazole, Mycostatin, Nilstat |
| Type | |
| Formula | C47H75NO17 |
| Weight | Average: 926.107 Monoisotopic: 925.503499959 |
| Protein binding | Nystatin is not absorbed into the systemic circulation and is therefore not subject to plasma protein binding. |
| Groups | Approved, Vet approved |
| Therapeutic Class | Drugs for subcutaneous and systemic mycoses, Drugs used in Vaginal and Vulval condition |
| Manufacturer | |
| Available Country | Switzerland |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Multilind Pâte Curative Cream is used for the treatment of cutaneous or mucocutaneous mycotic infections caused by Candida albicans and other susceptible Candida species. This cream is not used for systemic, oral, intravaginal or ophthalmic use.
Multilind Pâte Curative tablet is an antifungal antibiotic active against a wide range of yeasts and yeast like fungi including Candida albicans. It is used for the prevention and treatment of Candida infections of oral cavity, esophagus and intestinal tract. It provides effective prophylaxis against oral candidiasis in those born of mothers with vaginal candidiasis. It is used for the prophylaxis of Candida overgrowth during courses of broadspectrum antibiotics
Multilind Pâte Curative is also used to associated treatment for these conditions: Anal candidiasis, Candidiasis, Invasive, Intestinal Candidiasis, Mixed Vaginal Infections caused by Trichomonas Vaginalis, candida albicans, Oral Candidiasis, Pruritus Ani, Pruritus Vulvae, Skin candida, Trichomonas Vaginitis, Vaginal Candidiasis, Vulvovaginal Candidiasis, Corticosteroid-responsive dermatoses, Cutaneous candidiasis
How Multilind Pâte Curative works
Multilind Pâte Curative is a channel-forming ionophore, meaning it exerts its therapeutic effect via formation of a membrane-spanning pore in the fungal plasma membrane. The formation of this pore results in a change in membrane permeability that allows for leakage of intracellular contents and the subsequent disruption of electrochemical gradients necessary for proper cell function. Selectivity for fungal cells over mammalian cells is due to nystatin’s greater binding affinity for ergosterol, a key sterol found in fungal cell walls, as opposed to its mammalian counterpart, cholesterol.
Dosage
Multilind Pâte Curative dosage
Children:
- In intestinal and oral candidiasis (thrush): 1,00,000 units (1 ml) should be dropped into the mouth four times daily.The longer the suspension is kept in contact with the affected area in the mouth, before swallowing, the greater will be its effect.
- For prophylaxis in the newborn:The suggested dose is 1,00,000 units (1 ml) once daily or as prescribed by the physician.
Adult:
- For the treatment of intestinal or esophageal candidiasis: 5,00,000 units (5 ml) by mouth 3 or 4 times daily. The dose may be doubled, if required.
- For prophylaxis of intestinal candidiasis in adults: 10,00,000 units (10 ml) daily.
- For prophylaxis to suppress the over growth of Candida albicans in patients receiving broad spectrum antibiotic therapy: 10,00,000 units (10 ml) daily.
- For the treatment of dental sores and oral infection: 1,00,000 units (1 ml) suspension should be dropped into the mouth four times daily.
Elderly: Older people with intestinal candidiasis who are unable to swallow tablets should be given 5,00,000 units (5 ml) suspension four times daily.
Adults and Pediatric Patients (Neonates and Older): Apply liberally to affected areas twice daily or as indicated until healing is complete.
Pediatric Use: Safety and effectiveness have been established in the pediatric population from birth to 16 years.
Geriatric Use: Clinical studies with nystatin cream did not include sufficient numbers of subjects aged 65 years and older to determine whether they respond differently than younger subjects. Other reported clinical experience has not identified differences in responses between elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out.
Side Effects
Multilind Pâte Curative cream: The frequency of adverse events reported in patients using nystatin cream is less than 0.1%. The more common events that were reported include allergic reactions, burning, itching, rash, eczema, and pain on application.
Multilind Pâte Curative tablet: Nausea, vomiting and diarrhoea have occasionally been reported with high doses of Multilind Pâte Curative. No systemic effects or allergic reactions have been associated with its oral dose.
Toxicity
The oral LD50 in rats is 10 g/kg. There have been no reports of serious toxic effects following overdosage of nystatin - doses in excess of five million units daily have resulted in nausea and gastrointestinal upset with no other associated effects.
Precaution
Multilind Pâte Curative cream should not be used for the treatment of systemic, oral, intravaginal or ophthalmic infections. If irritation or sensitization develops, treatment should be discontinued and appropriate measures taken as indicated. It is recommended that KOH smears, cultures, or other diagnostic methods be used to confirm the diagnosis of cutaneous or mucocutaneous candidiasis and to rule out infection caused by other pathogens.
Absorption from the gastrointestinal tract is negligible, therefore no special precaution is required to apply in pregnancy and lactation
Food Interaction
No interactions found.Volume of Distribution
Multilind Pâte Curative is not absorbed into the systemic circulation and thus does not undergo distribution.
Elimination Route
Systemic absorption of nystatin is minimal following oral administration, and no detectable plasma concentrations are attained following topical or vaginal administration.
Elimination Route
The majority of orally administered nystatin is eliminated unchanged in the feces.
Pregnancy & Breastfeeding use
Pregnancy Category C. Animal reproduction studies have not been conducted with any nystatin cream. It also is not known whether this cream can cause fetal harm when used by a pregnant woman or can affect reproductive capacity. Multilind Pâte Curative cream should be prescribed for a pregnant woman only if the potential benefit to the mother outweighs the potential risk to the fetus.
Nursing Mothers: It is not known whether nystatin is excreted in human milk. Caution should be exercised when nystatin is prescribed for a nursing woman.
Mouth/Throat/PO/Topical: Pregnancy catagory C
Vaginal: Pregnancy catagory A
Contraindication
Multilind Pâte Curative cream is contraindicated in patients with a history of hypersensitivity to any of its components.
There is no known contraindication to the use of Multilind Pâte Curative oral.
Storage Condition
Store at 20° to 25°C. Avoid freezing.
Innovators Monograph
You find simplified version here Multilind Pâte Curative
Multilind Pâte Curative contains Nystatin see full prescribing information from innovator Multilind Pâte Curative Monograph, Multilind Pâte Curative MSDS, Multilind Pâte Curative FDA label
FAQ
What is Multilind Pâte Curative used to treat?
Multilind Pâte Curative is an antifungal medicine. It's used to treat or prevent infections caused by a fungus.
How safe is Multilind Pâte Curative?
Multilind Pâte Curative is generally very safe. Taking too much is unlikely to harm you or your child. If you're worried, speak to your pharmacist or doctor.
How does Multilind Pâte Curative work?
Multilind Pâte Curative work by kills the fungus and treats the infection. If you're taking Multilind Pâte Curative to prevent an infection, the medicine kills any fungus as it starts to appear.
What are the common side effects of Multilind Pâte Curative?
Common side effects of Multilind Pâte Curative may include: mouth irritation; upset stomach, nausea, vomiting, diarrhea; skin rash.
Is Multilind Pâte Curative safe during pregnancy?
Topical Multilind Pâte Curative is a safe alternative to azole anti-fungals that has been extensively studied in the first trimester of pregnancy. As Multilind Pâte Curative has negligible systemic absorption, no associated risk of major malformations has been observed in numerous trials.
Is Multilind Pâte Curative safe during breastfeeding?
It's usually safe to take Multilind Pâte Curative liquid while you're breastfeeding.
Can I drink alcohol with Multilind Pâte Curative?
Avoid drinking alcohol while taking this drug and for at least 1 day after the last dose. Drinking alcohol or taking products that have alcohol may cause flushing, throwing up, or fast heartbeat. Have blood work checked as you have been told by the doctor.
How many days does it take for Multilind Pâte Curative to work?
Multilind Pâte Curative usually starts to work after 2 days. It's important to continue to take or use Multilind Pâte Curative for 2 days after your condition is better. This will help to stop it coming back again.
When is the best time to take Multilind Pâte Curative?
You usually take Multilind Pâte Curative liquid 4 times a day after meals and before bedtime. It's important not to eat or drink for 30 minutes after taking the liquid.
Do I take Multilind Pâte Curative with food or without food?
You can take Multilind Pâte Curative with or without food.
What does Multilind Pâte Curative do for thrush?
Multilind Pâte Curative is also quite common for young babies to have oral thrush.Multilind Pâte Curative suspension (drops) are an option for the treatment of oral thrush.
Can I take Multilind Pâte Curative for a long time?
People usually only take Multilind Pâte Curative for around a week to clear the infection. If you're using a Multilind Pâte Curative cream or ointment mixed with other ingredients, only use for longer than 7 days if your doctor tells you to.
How long can I stay on Multilind Pâte Curative?
Most doctors recommend that you continue to use the drops for two days after your symptoms have gone a typical course of treatment will last around seven days.
Who should not take Multilind Pâte Curative?
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
What are the contraindications for Multilind Pâte Curative?
Multilind Pâte Curative tablets are contraindicated in patients with a history of hypersensitivity to any of their components.
Is Multilind Pâte Curative safe for adults?
Most adults and children, including babies, can take nystatin liquid or use nystatin cream and ointments.
Can Multilind Pâte Curative cause liver damage?
Multilind Pâte Curative is considered very safe and is unlikely to cause hepatic injury.
Can Multilind Pâte Curative cause stomach pain?
Multilind Pâte Curative can causes stomach pain also with other side effects.
What happen If I missed Multilind Pâte Curative?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I take too much Multilind Pâte Curative?
Multilind Pâte Curative is generally very safe. Taking too much is unlikely to harm you or your child. If you're worried, speak to your pharmacist or doctor.
Can Multilind Pâte Curative cure yeast infection?
Multilind Pâte Curative topical (for the skin) is used to treat skin infections caused by yeast.Multilind Pâte Curative topical is not for use to treat a vaginal yeast infection.
