Muromonab

Muromonab Uses, Dosage, Side Effects, Food Interaction and all others data.

Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type 2a (IgG2a).

Used in organ transplant prophylaxis, Muromonab or OKT-3 binds specifically to the CD-3 complex, which is involved in antigen recognition and cell stimulation, on the surface of T lymphocytes. Immediately after administration CD-3-positive T lymphocytes are abruptly removed from circulation. It has been effective in reversing corticosteroid-resistant acute rejection in renal, liver, and cardiac transplant recipients.

Muromonab
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Trade Name	Muromonab
Generic	Muromonab
Muromonab Other Names	Anti-CD3, Muromonab-CD3
Type
Formula	C₆₄₆₀H₉₉₄₆N₁₇₂₀O₂₀₄₃S₅₆
Weight	146189.7 Da
Groups	Approved, Investigational
Therapeutic Class
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Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Muromonab is a monoclonal anti-CD3 antibody used as immunosuppressive therapy in kidney, heart, and liver transplant patients.

For treatment of organ transplant recipients, prevention of organ rejection

Muromonab is also used to associated treatment for these conditions: Kidney Transplant Rejection, Steroid resistant Heart transplant rejection, Steroid resistant hepatic transplant rejection

How Muromonab works

Muromonab binds to the T-cell surface glycoprotein CD3 epsilon chain. It appears to kill CD-3 positive cells by inducing Fc mediated apoptosis, antibody mediated cytotoxicity and complement-dependent cytotoxicity.