Myocrisin
Myocrisin Uses, Dosage, Side Effects, Food Interaction and all others data.
Myocrisin is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence of extensive deformities or in the treatment of other forms of arthritis.
Unknown, may decrease prostaglandin synthesis or may alter cellular mechanisms by inhibiting sulfhydryl systems.
| Trade Name | Myocrisin |
| Generic | Sodium aurothiomalate |
| Sodium aurothiomalate Other Names | Aurotiomalato sodico, Gold sodium thiomalate, Natrii aurothiomalas, Sodium aurothiomalate |
| Type | |
| Formula | C4H3AuNa2O4S |
| Weight | Average: 390.07 Monoisotopic: 389.921312 |
| Protein binding | About 85-90% of the drug is protein bound. |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | Australia, |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Myocrisin is a disease-modifying antirheumatic drug (DMARD) indicated for the symptomatic treatment of arthritis.
A disease-modifying antirheumatic drug (DMARD) indicated for the symptomatic treatment of arthritis.
Myocrisin is also used to associated treatment for these conditions: Felty's Syndrome, Psoriatic Arthritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile
How Myocrisin works
The precise mechanism of action is unknown. It is known that sodium aurothiomalate inhibits the synthesis of prostaglandins. The predominant action appears to be a suppressive effect on the synovitis of active rheumatoid disease.
Toxicity
Overdosage symptoms are those of heavy metal toxicity; they include pruritus, dermatitis, stomatitis, vague gastrointestinal discomfort, albuminuria with or without a nephrotic syndrome, hematuria, agranulocytosis, thrombocytopenic purpura, and aplastic anemia.
Food Interaction
No interactions found.Volume of Distribution
The apparent volume of distribution is 0.26 +/- 0.051 kg-1
Elimination Route
Gold sodium thiomalate solutions are rapidly absorbed following IM injection, with peak serum concentrations occurring in 3-6 hours.
Half Life
12.5 days
Clearance
7.0 ml/ kg/day
Elimination Route
The major route of elimination of an IV dose of gold sodium thiomalate is urinary excretion, with a mean of 35% of the dose found in the urine in ten days. Fecal elimination accounts for an additional 9.4% of the IV dose excreted in ten days, probably as a result of biliary secretion.
Innovators Monograph
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